FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\C1GalTA
Open Close
General Information
Symbol
Dmel\C1GalTA
Species
D. melanogaster
Name
Core 1 Galactosyltransferase A
Annotation Symbol
CG9520
Feature Type
protein_coding_gene
FlyBase ID
FBgn0032078
Gene Model Status
Current
Stock Availability
15 publicly available
Enzyme Name (EC)
N-acetylgalactosaminide beta-1,3-galactosyltransferase (2.4.1.122)
Gene Summary
Core 1 Galactosyltransferase A (C1GalTA) encodes a Golgi protein that catalyzes the attachment of α-D-galactose to the O-linked GalNAc in selected membrane or secreted proteins. This Gal(β1,3)GalNAc-O glycan is known as the T antigen. Its roles include hematopoietic stem cell maintenance, neural network and neuromuscular junction formation. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dC1GalT1, C1GalT1, core 1 β1,3-galactosyltransferase, DmC1GalT1

Key Links
Genomic Location
Cytogenetic map
29F5-29F5
Sequence location
Recombination map
2-34
RefSeq locus
NT_033779 REGION:8943455..8951216
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (14 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables beta-1,3-galactosyltransferase activity
inferred from direct assay
(Müller et al., 2005)
enables manganese ion binding
inferred from direct assay
(González-Ramírez et al., 2022)
enables N-acetylgalactosaminide beta-1,3-galactosyltransferase activity
inferred from direct assay
(González-Ramírez et al., 2022, Lin et al., 2008)
inferred from direct assay
(Wang et al., 2026, Rong et al., 2025)
inferred from mutant phenotype
(Yoshida et al., 2008)
enables protein homodimerization activity
inferred from direct assay
(González-Ramírez et al., 2022)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables glycosyltransferase activity
inferred from electronic annotation with InterPro:IPR003378
(InterPro Project Members, 2004-)
enables N-acetylgalactosaminide beta-1,3-galactosyltransferase activity
inferred from biological aspect of ancestor with PANTHER:PTN000547277
(GO Reference Genome Project, 2011-)
Biological Process (7 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in central nervous system morphogenesis
inferred from mutant phenotype
(Lin et al., 2008)
involved_in glycolipid biosynthetic process
inferred from direct assay
(Müller et al., 2005)
involved_in muscle cell development
inferred from mutant phenotype
(Itoh et al., 2016)
involved_in negative regulation of hematopoietic stem cell differentiation
inferred from mutant phenotype
(Fuwa et al., 2015)
involved_in neuromuscular junction development
inferred from mutant phenotype
(Itoh et al., 2016)
involved_in protein O-linked glycosylation via N-acetyl-galactosamine
inferred from direct assay
(González-Ramírez et al., 2022)
inferred from direct assay
(Müller et al., 2005)
involved_in regulation of filopodium assembly
inferred from mutant phenotype
(Fuwa et al., 2015)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in Golgi membrane
inferred from sequence or structural similarity with UniProtKB:A0A8R1WG47
(Gene Ontology Curators, 2002-)
located_in membrane
inferred from sequence or structural similarity with UniProtKB:Q9NS00
(Gene Ontology Curators, 2002-)
inferred from electronic annotation with InterPro:IPR003378
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (Q7K237)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
N-acetylgalactosaminide beta-1,3-galactosyltransferase activity
an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+) (2.4.1.122)
RHEA 15621:
Summaries
Gene Snapshot
Core 1 Galactosyltransferase A (C1GalTA) encodes a Golgi protein that catalyzes the attachment of α-D-galactose to the O-linked GalNAc in selected membrane or secreted proteins. This Gal(β1,3)GalNAc-O glycan is known as the T antigen. Its roles include hematopoietic stem cell maintenance, neural network and neuromuscular junction formation. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
CORE 1 BETA 1,3-GALACTOSYLTRANSFERASES -
Core 1 beta 1,3-galactosyltransferases (core 1 GalTs) elongate O-linked N-acetylgalactosamine (O-GalNAc) by adding galactose in a β1,3 linkage, thereby building the 'T-antigen' or 'core-1' structure. In contrast to mammals, in which only one core 1 GalT has been identified, D. melanogaster has several such (putative) enzymes, each expressed in distinct patterns. (Adapted from FBrf0207265.)
Pathway (FlyBase)
PROTEIN O-GalNAcYLATION -
Protein O-linked GalNAcylation is a post-translational modification that occurs in the Golgi apparatus. The synthesis of O-linked GalNAc glycans (also known as mucin-type O-glycans) begins with the attachment of a N-acetyl-galactosamine (GalNAc) via an α-glycosidic bond to the hydroxyl group of serine or threonine residues in secreted and membrane proteins; this monosaccharide O-glycan is known as the Tn antigen. The O-linked GalNAc can be extended by the addition of a galactose, forming the core 1 T antigen. A glucuronic acid can be further attached to the galactose resulting in the formation of a linear glycan. In D. melanogaster, Tn and T antigens are the most prevalent type of O-glycans and are involved in a broad range of processes, including cell recognition, adhesion and signaling. (Adapted from FBrf0244700 and FBrf0243014.)
Protein Function (UniProtKB)
Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
(UniProt, Q7K237)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\C1GalTA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7K237)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
C1GalTA-RA
FBtr0079790
NM_164839
1931
388
C1GalTA-RB
FBtr0079788
NM_135414
2227
388
C1GalTA-RC
FBtr0079789
NM_164840
2019
388
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
C1GalTA-PA
FBpp0079390
44.3
388
6.65
Q7K237
NP_723427
AAF52725
C1GalTA-PB
FBpp0079388
44.3
388
6.65
Q7K237
NP_609258
AAF52723
C1GalTA-PC
FBpp0079389
44.3
388
6.65
Q7K237
NP_723428
AAF52724
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

388 aa isoforms: C1GalTA-PA, C1GalTA-PB, C1GalTA-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Homodimer; disulfide-linked.

(UniProt, Q7K237)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\C1GalTA using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.26

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 2
organism | ubiquitous
(Müller et al., 2005)
embryonic stage 9 -- 10
amnioserosa
(Fisher et al., 2012)
amnioserosa primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012, Müller et al., 2005)
embryonic stage 12 -- 14
amnioserosa
(Lin et al., 2008)
embryonic stage 13 -- 16
amnioserosa
(Fisher et al., 2012)
embryonic/larval crystal cell
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic stage 16
larval ventral nerve cord
(Lin et al., 2008)
larval brain
(Lin et al., 2008)
larval central nervous system
(Lin et al., 2008)
larval stage
embryonic/larval gut
(Lin et al., 2008)
first instar larval stage
larval central nervous system
(Lin et al., 2008)
third instar larval stage
larval ventral nerve cord
(Lin et al., 2008)
larval brain
(Lin et al., 2008)
wing disc
(Lin et al., 2008)
imaginal disc
(Lin et al., 2008)
adult stage | male
ejaculatory duct
(Lin et al., 2008)
adult stage | female
nurse cell
(Lin et al., 2008)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
brain
(Yoshida et al., 2008)
eye disc
(Yoshida et al., 2008)
leg disc
(Yoshida et al., 2008)
embryonic/larval salivary gland
(Yoshida et al., 2008)
adult stage | male
testis
(Yoshida et al., 2008)
adult stage | female
ovary
(Yoshida et al., 2008)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 16
larval central nervous system
(Yoshida et al., 2008)
embryonic stage 16
embryonic/larval hemocyte
(Yoshida et al., 2008)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Expression of C1GalTA was inferred by staining with an antibody to T antigen and comparing staining in C1GalTA mutant and wild type embryos. Staining was observed in the CNS and in hemocytes in the embryo.

(Yoshida et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\C1GalTA in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 13 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of C1GalTA
Transgenic constructs containing regulatory region of C1GalTA
Aberrations (Deficiencies and Duplications) ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with C1GalTA2.1)
lethal (with C1GalTA30.1)
lethal | recessive
lethal - all die before end of pupal stage (with Df(2L)ED647)
lethal - all die before end of pupal stage (with Df(2L)Exel7040)
lethal - all die before end of pupal stage | recessive
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Scer\GAL4Act5C.PU
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal cell migration | embryonic stage 12
abnormal cell migration | embryonic stage 12, with Scer\GAL4srp.Hemo
abnormal cell number | embryonic stage 12
abnormal cell number | embryonic stage 12, with Scer\GAL4srp.Hemo
abnormal neuroanatomy | larval stage
abnormal neuroanatomy | larval stage (with C1GalTA2.1)
abnormal neuroanatomy | larval stage (with C1GalTAEY13370)
abnormal neuroanatomy | larval stage (with C1GalTAjs1)
abnormal neuroanatomy | larval stage (with C1GalTAjs2)
abnormal neuroanatomy | larval stage (with Df(2L)BSC204)
abnormal neuroanatomy | larval stage (with Df(2L)Exel7040)
decreased cell number | embryonic stage 12, with Scer\GAL4srp.Hemo
some die during pupal stage, with Scer\GAL4pnr-MD237
some die during pupal stage (with Df(2L)ED647)
some die during pupal stage (with Df(2L)Exel7040)
some die during pupal stage | recessive
Phenotype manifest in
Allele
basement membrane | larval stage (with C1GalTA2.1)
basement membrane | larval stage (with C1GalTAEY13370)
basement membrane | larval stage (with Df(2L)Exel7040)
embryonic/larval crystal cell | ectopic
embryonic/larval crystal cell | increased number
embryonic/larval hemolymph
embryonic/larval lymph gland
embryonic/larval plasmatocyte
embryonic/larval plasmatocyte | ectopic
embryonic/larval plasmatocyte | embryonic stage 12
embryonic/larval plasmatocyte | embryonic stage 12, with Scer\GAL4srp.Hemo
endocytic vesicle | larval stage (with C1GalTA2.1)
endocytic vesicle | larval stage (with C1GalTAEY13370)
germ band | embryonic stage 12
germ band | embryonic stage 12, with Scer\GAL4srp.Hemo
larval brain
larval brain (with C1GalTAjs1)
larval brain (with C1GalTAjs2)
larval central nervous system
larval central nervous system (with C1GalTAjs1)
larval central nervous system (with C1GalTAjs2)
larval central nervous system (with Df(2L)BSC204)
larval ventral nerve cord
larval ventral nerve cord (with C1GalTAjs1)
larval ventral nerve cord (with C1GalTAjs2)
leg
lymph gland posterior signaling center cell
myofibril | larval stage (with C1GalTA2.1)
myofibril | larval stage (with C1GalTAEY13370)
NMJ bouton | larval stage (with C1GalTA2.1)
NMJ bouton | larval stage (with C1GalTAEY13370)
NMJ bouton | larval stage (with Df(2L)Exel7040)
posterior signaling center of lymph gland primary lobe
postsynaptic density | larval stage (with C1GalTA2.1)
postsynaptic density | larval stage (with C1GalTAEY13370)
sarcomere | larval stage (with C1GalTA2.1)
sarcomere | larval stage (with C1GalTAEY13370)
subsynaptic reticulum | larval stage (with C1GalTA2.1)
subsynaptic reticulum | larval stage (with C1GalTAEY13370)
yolk | embryonic stage 12
yolk | embryonic stage 12, with Scer\GAL4srp.Hemo
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (20)
Hsap\C1GALT1
12 of 14
Yes
Yes
Hsap\C1GALT1C1
4 of 14
No
No
Hsap\B3GLCT
2 of 14
No
No
Hsap\C1GALT1C1L
2 of 14
No
No
Hsap\B3GALNT1
1 of 14
No
No
Hsap\B3GALT1
1 of 14
No
No
Hsap\B3GNT2
1 of 14
No
No
Hsap\B3GNT3
1 of 14
No
No
Hsap\B3GNT4
1 of 14
No
No
1  
Hsap\B3GNT5
1 of 14
No
No
1  
Hsap\B3GNT6
1 of 14
No
No
Hsap\B3GNT7
1 of 14
No
No
Hsap\CHPF2
1 of 14
No
No
1  
Hsap\CHPF
1 of 14
No
No
Hsap\CHSY1
1 of 14
No
No
Hsap\CHSY3
1 of 14
No
No
Hsap\CSGALNACT2
1 of 14
No
No
Hsap\LFNG
1 of 14
No
No
Hsap\MFNG
1 of 14
No
No
1  
Hsap\RFNG
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (22)
Rnor\C1galt1
12 of 14
Yes
Yes
Rnor\C1galt1c1
4 of 14
No
No
Rnor\B3galnt1
1 of 14
No
No
Rnor\B3galt1
1 of 14
No
No
Rnor\B3galt5
1 of 14
No
No
Rnor\B3glct
1 of 14
No
No
Rnor\B3gnt2
1 of 14
No
No
Rnor\B3gnt3
1 of 14
No
No
Rnor\B3gnt4
1 of 14
No
No
Rnor\B3gnt5
1 of 14
No
No
Rnor\B3gnt6
1 of 14
No
No
Rnor\B3gnt7
1 of 14
No
No
Rnor\B3gnt9
1 of 14
No
No
Rnor\B4galnt4
1 of 14
No
No
Rnor\Chpf2
1 of 14
No
No
Rnor\Chpf
1 of 14
No
No
Rnor\Chsy1
1 of 14
No
No
Rnor\Chsy3
1 of 14
No
No
Rnor\Csgalnact2
1 of 14
No
No
Rnor\Lfng
1 of 14
No
No
Rnor\Mfng
1 of 14
No
No
Rnor\Rfng
1 of 14
No
No
Mus musculus (laboratory mouse) (22)
Mmus\C1galt1
11 of 14
Yes
Yes
Mmus\C1galt1c1
4 of 14
No
No
Mmus\B3glct
2 of 14
No
No
Mmus\B3galnt1
1 of 14
No
No
Mmus\B3galt1
1 of 14
No
No
Mmus\B3galt5
1 of 14
No
No
Mmus\B3gnt2
1 of 14
No
No
Mmus\B3gnt3
1 of 14
No
No
Mmus\B3gnt4
1 of 14
No
No
Mmus\B3gnt5
1 of 14
No
No
Mmus\B3gnt6
1 of 14
No
No
Mmus\B3gnt7
1 of 14
No
No
Mmus\B3gnt9
1 of 14
No
No
Mmus\B4galnt4
1 of 14
No
No
Mmus\Chpf2
1 of 14
No
No
Mmus\Chpf
1 of 14
No
No
Mmus\Chsy1
1 of 14
No
No
Mmus\Chsy3
1 of 14
No
No
Mmus\Csgalnact2
1 of 14
No
No
Mmus\Lfng
1 of 14
No
No
1  
Mmus\Mfng
1 of 14
No
No
2  
Mmus\Rfng
1 of 14
No
No
2  
Xenopus tropicalis (Western clawed frog) (16)
Xtro\c1galt1
10 of 13
Yes
Yes
Xtro\LOC100486174
9 of 13
No
Yes
Xtro\vav1
8 of 13
No
Yes
Xtro\LOC100486323
6 of 13
No
Yes
Xtro\XB5871033
6 of 13
No
No
Xtro\b3gnt5
1 of 13
No
No
Xtro\b3gnt7
1 of 13
No
No
Xtro\b3gnt9
1 of 13
No
No
Xtro\c1galt1c1
1 of 13
No
Yes
Xtro\chsy1
1 of 13
No
No
Xtro\chsy3
1 of 13
No
No
Xtro\csgalnact1
1 of 13
No
No
Xtro\csgalnact2
1 of 13
No
No
Xtro\LOC100485879
1 of 13
No
No
Xtro\LOC100486030
1 of 13
No
No
Xtro\rfng
1 of 13
No
No
Danio rerio (Zebrafish) (22)
Drer\c1galt1a
11 of 14
Yes
No
Drer\c1galt1b
10 of 14
No
No
Drer\si:dkey-202e17.1
9 of 14
No
Yes
Drer\LOC564281
7 of 14
No
Yes
Drer\c1galt1c1
4 of 14
No
No
Drer\aars2
1 of 14
No
No
Drer\b3glcta
1 of 14
No
No
Drer\b3glctb
1 of 14
No
No
Drer\b3gnt5b
1 of 14
No
No
Drer\b3gnt9
1 of 14
No
No
Drer\b4galnt4a
1 of 14
No
No
Drer\b4galnt4b
1 of 14
No
No
Drer\chpf2
1 of 14
No
No
Drer\chpfa
1 of 14
No
No
Drer\chpfb
1 of 14
No
No
Drer\chsy1
1 of 14
No
No
Drer\chsy3
1 of 14
No
No
Drer\csgalnact1a
1 of 14
No
No
Drer\csgalnact2
1 of 14
No
No
Drer\lfng
1 of 14
No
No
Drer\mfng
1 of 14
No
No
Drer\rfng
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (15)
Cele\C38H2.2
13 of 14
Yes
Yes
Cele\bus-4
6 of 14
No
Yes
Cele\C02H6.1
6 of 14
No
Yes
Cele\C16D9.6
6 of 14
No
Yes
Cele\E03H4.3
6 of 14
No
Yes
Cele\F56H6.1
6 of 14
No
Yes
Cele\Y38C1AB.1
6 of 14
No
Yes
Cele\C17A2.3
5 of 14
No
Yes
Cele\Y38C1AB.5
5 of 14
No
Yes
Cele\W09D10.5
4 of 14
No
Yes
Cele\T09E11.12
3 of 14
No
Yes
Cele\ZC250.2
2 of 14
No
No
Cele\F37A4.3
1 of 14
No
Yes
Cele\mig-22
1 of 14
No
No
Cele\sqv-5
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (7)
Agam\AgaP_AGAP009979
12 of 12
Yes
Yes
Agam\AgaP_AGAP012265
6 of 12
No
Yes
Agam\AgaP_AGAP009562
2 of 12
No
No
Agam\AgaP_AGAP001010
1 of 12
No
No
Agam\AgaP_AGAP001050
1 of 12
No
No
Agam\AgaP_AGAP006439
1 of 12
No
No
Agam\AgaP_AGAP007720
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (16)
Atha\AT1G01570
3 of 13
Yes
Yes
Atha\AT1G05280
3 of 13
Yes
Yes
Atha\AT1G33250
3 of 13
Yes
Yes
Atha\AT2G37730
3 of 13
Yes
Yes
Atha\AT3G11420
3 of 13
Yes
Yes
Atha\AT4G11350
3 of 13
Yes
Yes
Atha\AT4G23490
3 of 13
Yes
Yes
Atha\AT5G12460
3 of 13
Yes
Yes
Atha\AT5G41460
3 of 13
Yes
Yes
Atha\AT1G07850
2 of 13
No
No
Atha\AT4G00295
2 of 13
No
Yes
Atha\AT4G15240
2 of 13
No
Yes
Atha\AT2G26100
1 of 13
No
No
Atha\AT4G00300
1 of 13
No
No
Atha\AT4G23493
1 of 13
No
Yes
Atha\AT5G57500
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:C1GalTA. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (17)
CG8708
11 of 13
CG2975
8 of 13
tgy
7 of 13
CG3119
6 of 13
CG18558
6 of 13
CG34056
6 of 13
CG34057
6 of 13
CG34452
6 of 13
CG2983
5 of 13
CG34451
5 of 13
CG9109
2 of 13
CG30036
1 of 13
Chpf
1 of 13
Chsy
1 of 13
Csgalnact
1 of 13
fng
1 of 13
GalT1
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    C1GalTAEY13370
    model of  autoimmune disease of blood
    CEA
    (Fuwa et al., 2015)
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    C1GALT1; core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
    12 of 14
    610555
        C1GALT1C1; C1GALT1 specific chaperone 1
        4 of 14
        300611
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        C1GalTA
        suppressible
        Hml
        (Fuwa et al., 2015)
        C1GalTA
        suppressible
        rpr
        (Fuwa et al., 2015)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Subunit Structure (UniProtKB)
        Homodimer; disulfide-linked.
        (UniProt, Q7K237 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        PROTEIN O-GalNAcYLATION
        External Links
        FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
        KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        External Data
        Linkouts
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map
        2-34
        Cytogenetic map
        29F5-29F5
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        29F5-29F5
        Limits computationally determined from genome sequence between P{lacW}l(2)k04003k04003 and P{PZ}tai01351
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-34

        (FlyBase, 2016)

        2-29.6

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (15)
        Genomic Clones (14)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (73)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments
              Relationship to Other Genes
              Source for database merge of

              Source for merge of: CG9520 anon-WO0144478.18

              (FlyBase, 1996-)
              Additional comments

              Source for merge of CG9520 anon-WO0144478.18 was sequence comparison ( date:051113 ).

              (FlyBase, 1996-)
              Nomenclature History
              Source for database identify of

              Source for identity of: C1GalTA CG9520

              (Lin et al., 2008)
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (12)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 54 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              PDB - An information portal to biological macromolecular structures
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              References (59)