FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\C1GalTAEY13370
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General Information
Symbol
Dmel\C1GalTAEY13370
Species
D. melanogaster
Name
FlyBase ID
FBal0160794
Feature type
allele
Associated gene
Dmel\C1GalTA
Associated Insertion(s)
P{EPgy2}C1GalTAEY13370
Carried in Construct
Also Known As
dC1GalT1EY13370
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Itoh et al., 2016)
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}C1GalTAEY13370
Cytology
Description

Insertion in the first intron.

(Yoshida et al., 2008)
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  autoimmune disease of blood
      CEA
      (Fuwa et al., 2015)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      C1GalTAEY13370/C1GalTA2.1 and C1GalTAEY13370/Df(2L)Exel7040 mutant larvae exhibit partial loss of the basement membrane, along with mislocalized neuromuscular junction boutons at the muscle 6/7 boundary, but no difference in the overall number of NMJ boutons, as compared to controls.

      NMJs in C1GalTAEY13370/C1GalTA2.1 mutant larvae exhibit increased numbers of endocytic vesicles, increased thickness of subsynaptic reticulum per bouton area, decreased subsynaptic reticulum density, and decreased postsynaptic density length, but no significant difference in the number of synaptic vesicles, postsynaptic densities per bouton, or postsynaptic depth, as compared to wild type. Muscle fibers in C1GalTAEY13370/C1GalTA2.1 mutant larvae exhibit ectopic vacuole-like structures around the nucleus in myofibrils, and defective sarcomere structure, duplicate basement membranes, and increased basement membrane thickness, as compared to controls.

      (Itoh et al., 2016)

      In contrast to wild type, mature plasmatocytes are found in the secondary lobes of C1GalTAEY13370 mutant larval lymph glands.

      The number of crystal cells is dramatically increased in the lymph glands of C1GalTAEY13370 mutant larvae, and unlike in wild type some are found in the secondary lobe.

      Hematopoietic stem cells (HSCs) are absent from the lymph glands of C1GalTAEY13370 mutant larvae.

      A similar number of posterior signaling center (PSC) cells is found in the posterior-medial region of C1GalTAEY13370 mutant lymph glands as in wild type larvae, but they are more densely packed in a narrow region of the lymph gland than in controls. The length of their filopodial extensions is greatly reduced compared with wild type larvae, although the number of protrusions from PSC cells is similar.

      The lymph glands of C1GalTAEY13370 mutant larvae exhibit morphological defects: in contrast to wild type lymph glands, which appear thin and flattened, the C1GalTAEY13370 mutant lymph glands are thick and have a rounded, smooth surface due to deposition of material from blood cells.

      The hemolymph in C1GalTAEY13370 mutant larvae appears to be more viscous than that of wild type larvae.

      (Fuwa et al., 2015)

      Some homozygotes die during development. Homozygous adult escapers have abnormal legs.

      Mutant larvae have a reduced number of circulating plasmatocytes compared to control larvae.

      (Yoshida et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Hmlf03374 partially suppresses the atypical surface structure seen in the lymph gland of C1GalTAEY13370 mutant larvae. The morphological defects seen in C1GalTAEY13370 mutant lymph glands are not significantly suppressed.

      Expression of HmlGD1292 under the control of Scer\GAL4Hml.PU reduces the atypical surface structure seen in the lymph glands of C1GalTAEY13370 mutant larvae. The reduction in hematopoetic stem cell number and posterior signaling center (PSC) cell filopodial production is suppressed.

      Expression of rprScer\UAS.cUa under the control of Scer\GAL4Hml.PU suppresses the increase in plasmatocytes seen in C1GalTAEY13370 mutant lymph glands. The atypical lymph gland surface and the reduction in hematopoietic stem cells are also suppressed.

      (Fuwa et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      C1GalTA2.1/C1GalTAEY13370 is rescued by C1GalTAUAS.cFa

      (Itoh et al., 2016)

      C1GalTAEY13370 is rescued by C1GalTAUAS.cFa/Scer\GAL4srp.Hemo

      (Fuwa et al., 2015)
      Partially rescued by

      C1GalTAEY13370 is partially rescued by C1GalTAUAS.cFa/Scer\GAL4Hml.PU

      (Fuwa et al., 2015)
      Not rescued by

      C1GalTAEY13370 is not rescued by C1GalTAUAS.cFa/Scer\GAL4kn.PU

      (Fuwa et al., 2015)
      Comments

      Expression of C1GalTAScer\UAS.cFa under the control of Scer\GAL4Act5C.PU rescues the basement membrane loss of C1GalTAEY13370/C1GalTA2.1 mutants.

      (Itoh et al., 2016)

      Expression of C1GalTAScer\UAS.cFa under the control of Scer\GAL4kn.PU fails to rescue the defects in filopodial extension seen in the posterior organizing center (PSC) cells of C1GalTAEY13370 mutant larvae.

      Expression of C1GalTAScer\UAS.cFa in plasmatocytes under the control of Scer\GAL4Hml.PU rescues the defects in filopodial extension seen in the posterior organizing center (PSC) cells of C1GalTAEY13370 mutant larvae. Hematopoietic stem cells (HSCs) are restored to the medial region of the lymph gland but the number of crystal cell remains higher than in wild type.

      Expression of C1GalTAScer\UAS.cFa in a subset of plasmatocytes under the control of Scer\GAL4srp.Hemo rescues the defects ectopic plasmatocyte phenotype seen in the lymph gland of C1GalTAEY13370 mutant larvae.

      Expression of C1GalTAScer\UAS.cFa under the control of Scer\GAL4Hml.PU rescues the thickening of the lymph gland seen in C1GalTAEY13370 mutant larvae.

      (Fuwa et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      C1GalTAEY13370
      C1β3GalT1EY13370
      (Fuwa et al., 2015)
      CG9520EY13370
      (Yoshida et al., 2008)
      dC1GalT1EY13370
      (Itoh et al., 2018, Itoh et al., 2016)
      dC1GalT1EY
      (Itoh et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)