FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hmlf03374
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General Information
Symbol
Dmel\Hmlf03374
Species
D. melanogaster
Name
FlyBase ID
FBal0160327
Feature type
allele
Associated gene
Dmel\Hml
Associated Insertion(s)
PBac{WH}Hmlf03374
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Lesch et al., 2007)
Mutagen
piggyBac activity
(Bloomington Drosophila Stock Center, 2004.11.6)
Progenitor genotype
Associated Insertion(s)
PBac{WH}Hmlf03374
Cytology
Description
Allele components
Component
Use(s)
Inserted element
PBac{WH}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemolymph clots from Hmlf03374 third instar larvae show normal melanization.

      (Bidla et al., 2007)

      Hemolymph from mutant larvae fails to aggregate beads or to produce fibers in a drawout assay testing clotting function.

      Mutant larvae survive wounding as well as wild type.

      Mutant adults show similar survival to control flies when infected with E. coli.

      (Lesch et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      Hmlf03374 has abnormal immune response | larval stage phenotype, non-enhanceable by fonΔ24A

      (Bajzek et al., 2012)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Hmlf03374 is a suppressor | partially of embryonic/larval lymph gland phenotype of C1GalTAEY13370

      (Fuwa et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Hmlf03374 partially suppresses the atypical surface structure seen in the lymph gland of C1GalTAEY13370 mutant larvae. The morphological defects seen in C1GalTAEY13370 mutant lymph glands are not significantly suppressed.

      (Fuwa et al., 2015)

      fonΔ24A does not enhance the phenotype of reduced survival after wounding at the feeding stage which is seen in Hmlf03374 larvae.

      (Bajzek et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hmlf03374
      hmlf03374
      (Bajzek et al., 2012, Bidla et al., 2007, Lesch et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)