FlyBase Allele Report: Dmel\fon[Δ24A]

General Information

Symbol

Dmel\fon^Δ24A

Species

D. melanogaster

Name

FlyBase ID

FBal0277715

Feature type

allele

Associated gene

Dmel\fon

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

minos activity

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Bajzek et al., 2012)

Mutagen

minos activity

(Bajzek et al., 2012)

Progenitor genotype

Mi{ET1}CG17350^MB01546

(Bajzek et al., 2012)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in deletion of fon sequence without affecting CG17350 exons.

(Bajzek et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body size | P-stage

(Green et al., 2016)

abnormal body size | P-stage (with Df(2L)Exel6043)

(Green et al., 2016)

abnormal locomotor behavior | wandering third instar larval stage (with Df(2L)Exel6043)

(Green et al., 2016)

lethal - all die before end of pupal stage | recessive

(Bajzek et al., 2012)

some die during pupal stage | recessive

(Bajzek et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

fon^Δ24A homozygous and fon^Δ24A/Df(2L)Exel6043 transheterozygous pupae are elongated, as shown by a significant increase in the length/width axial ratio as compared to controls.

fon^Δ24A/Df(2L)Exel6043 transheterozygous wandering third instar larvae move at significantly lower speed in crawling assays, present significant detachment and rounding of myofibers, and present a significant increase in the hemisegmental gap between dorsal oblique muscles 1 and 2 without any associated detachment of the actin cytoskeleton from the sarcolemma, as compared to controls.

fon^Δ24A heterozygous wandering third instar larvae do not present significant increases in either the number of muscle detachments or in the size of the hemisegmental gap between dorsal oblique muscles 1 and 2, as compared to controls.

(Green et al., 2016)

Hemolymph from homozygous and fon^Δ24A/Df(2L)Exel6043 wandering larvae produces longer fibres than can be drawn from wild-type larvae in a drawout assay testing coagulation.

(Bajzek et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

fon^Δ24A is a non-enhancer of abnormal immune response | larval stage phenotype of Hml^f03374

(Bajzek et al., 2012)

Phenotype Manifest In

Enhancer of

Statement

Reference

fon^Δ24A/fon[+] is an enhancer of somatic muscle cell | wandering third instar larval stage phenotype of Scer\GAL4^da.PU, Tsp^KK108103

(Green et al., 2016)

NOT Enhancer of

Statement

Reference

fon^Δ24A/fon[+] is a non-enhancer of somatic muscle cell | wandering third instar larval stage phenotype of Lsp1γ^HMC04077, Scer\GAL4^da.PU

(Green et al., 2016)

Other

Statement

Reference

Tig^A1/Tig[+], fon^Δ24A has somatic muscle cell | wandering third instar larval stage phenotype

(Green et al., 2016)

Tig^A1/Tig[+], fon^Δ24A has muscle cell of dorsal oblique muscle 1 | wandering third instar larval stage phenotype

(Green et al., 2016)

Tig^A1/Tig[+], fon^Δ24A has muscle cell of dorsal oblique muscle 2 | wandering third instar larval stage phenotype

(Green et al., 2016)

Scer\GAL4^da.PU, Tig^JF01143, fon^Δ24A has somatic muscle cell | wandering third instar larval stage phenotype

(Green et al., 2016)

Scer\GAL4^da.PU, Tsp^KK108103, fon^Δ24A has somatic muscle cell | wandering third instar larval stage phenotype

(Green et al., 2016)

Lsp1γ^HMC04077, Scer\GAL4^da.PU, fon^Δ24A has somatic muscle cell | wandering third instar larval stage phenotype

(Green et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

fon^Δ24A, Tig^A1 double heterozygous wandering third instar larvae present significant increases in the number of muscle detachments and in the hemisegmental gap between dorsal oblique muscles 1 and 2, as compared to single heterozygous or wild-type controls.

fon^Δ24A heterozygous wandering third instar larvae expressing either Tig^JF01143 or Tsp^KK108103, but not Gel^JF01723 or Gel^HMS02269, under the control of Scer\GAL4^da.PU present a significant increase in the number of muscle detachments, as compared to fon^Δ24A heterozygotes or larvae with Scer\GAL4^da.PU-controlled expression of either Tig^JF01143, Tsp^KK108103, Gel^JF01723 or Gel^HMS02269, respectively; fon^Δ24A heterozygous wandering third instar larvae expressing Lsp1γ^HMC04077 under the control of Scer\GAL4^da.PU present a significant increase in muscle detachment as compared to fon^Δ24A heterozygotes, but not to larvae only expressing Lsp1γ^HMC04077 under the control of Scer\GAL4^da.PU.

(Green et al., 2016)

fon^Δ24A does not enhance the phenotype of reduced survival after wounding at the feeding stage which is seen in Hml^f03374 larvae.

(Bajzek et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

43644

w¹¹¹⁸; fon^Δ24A/CyO, P{ActGFP}JMR1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

fon^Δ24

(Green et al., 2016)

fon^Δ24A

Δ24A

(Bajzek et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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