cv 2, Cv2
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.51
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cv-2 using the Feature Mapper tool.
cv-2 expression is first visible broadly around the crossveins and the end of the longitudinal veins at 21-22 hr APF. It becomes stronger and refines to a narrow stripe at 28-29 hr APF.
cv-2 transcripts are most prominent near the anterior-posterior compartment boundaries in third instar imaginal discs, in the anterior and posterior crossveins in pupal wings and at the distal edges of longitudinal wing veins. Heightened expression is also observed in the dorsal regions of early embryos.
Weak general expression is seen at all stages. In late third instar larvae, cv-2 transcripts are observed in three regions of the prospective notum. One contains and lies distal to the posterior notopleural bristle (pNP) and lies posterior to the anterior notopleural bristle (aNP). One lies distal to the trichoid sensillum (tri1). Transcripts are emphasized along the AP boundary of the prospective wing blade. In pupal wings at 19 hrs APF, transcripts are seen in broad regions around the crossveins. These resolve into narrower regions by 28 hr APF. Increased expression is also observed at the tips of the longitudinal veins.
GBrowse - Visual display of RNA-Seq signalsView Dmel\cv-2 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Mutations in cv-2 remove transverse veins or crossveins: crossvein specific. Shows additive interactions with vn, ve, ci, cg, shv, ast, H, Vno, vvl, ri, tg, tt and ab.
ri, tg, tt, ab, cv, cv-2, cv-c and cv-d belong to the radius incompletus phenotypic group within the 'lack-of-vein' mutant class. Loss-of-function alleles at these loci remove stretches of veins in two or more longitudinal veins. Double mutants of this group have additive phenotypes suggesting the genes are vein-specific, and have small lanceolate wings. Genes are involved in whole vein region-specification rather than vein differentiation.
Nicoletti, Oct. 1962.