FlyBase Gene Report: Dmel\cv

General Information

Symbol

Dmel\cv

Species

D. melanogaster

Name

crossveinless

Annotation Symbol

CG12410

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000394

Gene Model Status

Current

Stock Availability

128 publicly available

Gene Summary

crossveinless (cv) encodes a member of the tumor suppressor gene family of BMP binding proteins. Its primary function is to help specify the posterior crossvein during pupal wing development by enhancing Dpp/Gbb signaling. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Red Book
Interactive Fly

Also Known As

tsg2

Key Links

Genomic Location

Cytogenetic map

5A13-5A13

Sequence location

X:5,690,002..5,693,084 [+]

Recombination map

1-12

RefSeq locus

NC_004354 REGION:5690002..5693084

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables BMP binding

inferred from physical interaction with FLYBASE:dpp; FB:FBgn0000490,FLYBASE:gbb; FB:FBgn0024234

(Shimmi et al., 2005)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in negative regulation of BMP signaling pathway

inferred from genetic interaction with FLYBASE:sog; FB:FBgn0003463,FLYBASE:gbb; FB:FBgn0024234

(Vilmos et al., 2005)

inferred from direct assay

(Shimmi et al., 2005)

inferred from genetic interaction with FLYBASE:sog; FB:FBgn0003463

(Shimmi et al., 2005)

involved_in positive regulation of BMP signaling pathway

inferred from mutant phenotype

(Matsuda et al., 2013, Shimmi et al., 2005, Vilmos et al., 2005)

inferred from genetic interaction with FLYBASE:dpp; FB:FBgn0000490,FLYBASE:gbb; FB:FBgn0024234

(Jaramillo et al., 2009)

involved_in positive regulation of muscle organ development

inferred from mutant phenotype

(Jaramillo et al., 2009)

involved_in regulation of imaginal disc-derived wing vein specification

inferred from mutant phenotype

(Shimmi et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of BMP signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000267834

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Shimmi et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN000267834

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Pathway (FlyBase)

POSITIVE REGULATORS OF BMP SIGNALING PATHWAY

NEGATIVE REGULATORS OF BMP SIGNALING PATHWAY

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Pathway (FlyBase)

POSITIVE REGULATORS OF BMP SIGNALING PATHWAY -: Positive regulators of Bone Morphogenetic Protein (BMP) signaling up-regulate the pathway, ultimately resulting in the increased nuclear activity of the Mad/Med transcription factor complex.
NEGATIVE REGULATORS OF BMP SIGNALING PATHWAY -: Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

cv: crossveinless

cv: crossveinless

From Weinstein, A., 1920, Proc. Nat. Acad. Sci. USA 6: 625-39.

Crossveins absent or traces only present. Veins L3 and L4 slightly delta at tips. Classifiable in unexpanded wings. Wing effects due to excessive contraction in the pupal period, obliterating the cavity which should normally remain between the epithelia to form the vein (Waddington, 1940, J. Genet. 41: 75-139). RK1.

Summary (Interactive Fly)

twisted gastrulation family member - along with Short gastrulation, Crossveinless promotes BMP signaling by transporting a Dpp/Gbb heterodimer from the longitudinal veins into the crossvein regions

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\cv for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W494)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

cv-RA

FBtr0070804

NM_080525

1893

257

cv-RB

FBtr0340464

NM_001297973

1308

257

cv-RC

FBtr0340465

NM_001297974

1742

257

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

cv-PA

FBpp0070770

28.9

257

4.36

FBpp0309406

28.9

257

4.36

FBpp0309407

28.9

257

4.36

Q9W494

NP_001284903

AHN59374

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

257 aa isoforms: cv-PA, cv-PB, cv-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cv using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

cv_1
cv_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.68

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 11

tracheal pit

(Jaramillo et al., 2009)

tracheal pit | surrounding

(Shimmi et al., 2005)

larval stage

wing disc | ubiquitous

(Shimmi et al., 2005)

pupal stage P5

pupal cuticle

Comment: just lateral to lumen of developing 2nd leg

(Jaramillo et al., 2009)

pupal stage P6

presumptive wing vein

(Shimmi et al., 2005)

Additional Descriptive Data

cv is detected in cells surrounding the tracheal pits at embryonic stage 11. Low and uniform expression is observed in wing imaginal discs. cv is enriched in the pupal wing at 21 hr APF in parallel stripes along the wing vein primordia.

(Shimmi et al., 2005)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Shimmi et al., 2005)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\cv in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\cv

View exonic expression by tissue for Dmel\cv

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000394

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44510/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000394

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000394

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000394

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12410

Flygut - An atlas of the Drosophila adult midgut

FBgn0000394

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 19 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of cv

Transgenic constructs containing regulatory region of cv

Aberrations (Deficiencies and Duplications) ( 60 )

Inferred from experimentation ( 60 )

Gene not disrupted in

(Patterson, 1932)

(Patterson, 1932)

(Patterson, 1932)

(Patterson, 1932)

(Patterson, 1932)

(Patterson, 1932)

(Patterson, 1932)

(Patterson, 1932)

(Patterson, 1932)

(Oliver et al., 1988)

Df(1)bi-DL5

(Oliver et al., 1988)

Df(1)ct268-37

(Demerec, 1940)

Df(1)GA56

(Oliver et al., 1988)

Df(1)GA102

(Oliver et al., 1988)

Df(1)HC244

(Oliver et al., 1988)

Df(1)HF366

(Oliver et al., 1988)

Df(1)JC70

(Oliver et al., 1988, Schalet, 1986)

Df(1)N73

(Jaramillo et al., 2009, Oliver et al., 1988, Craymer and Roy, 1980)

Df(1)ovo6

(Oliver et al., 1988)

Df(1)ovo7

(Oliver et al., 1988)

Df(1)rb1

(Oliver et al., 1988)

Df(1)rb13

(Oliver et al., 1988)

Df(1)rb30

(Oliver et al., 1988)

Df(1)rb33

(Oliver et al., 1988)

Df(1)rb46

(Oliver et al., 1988)

Df(1)rb47

(Oliver et al., 1988)

Df(1)RC40

(Oliver et al., 1988)

Df(1)Sp(rb)

(Schalet, 1986)

T(1;4)231b

(Patterson, 1932)

Gene disrupted in

Df(1)C149

(Jaramillo et al., 2009, Oliver et al., 1988, Craymer and Roy, 1980)

Df(1)Exel6236

(Ryder, 2004.4.26)

Df(1)M30

(Schultz, 1929)

Gene not duplicated in

Inferred from location ( 17 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

cv^GD3972

viable, with Scer\GAL4^Mef2.PR

cv^GD3972

viable, with Scer\GAL4^pnr-MD237

cv^GD3972

viable, with Scer\GAL4^tin.CΔ4

cv^GD3972

Sterility

Allele

fertile

cv^EY06384

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

cv^GD3972

abnormal jumping | partially | recessive

cv⁴³

visible

visible, with cv⁴³

cv^UAS.cVa

visible, with cv^UAS.cVa

cv⁴³

visible, with Scer\GAL4^ey.PH

cv^EP1349

visible | recessive

Phenotype manifest in

Allele

anterior crossvein

crossvein

eye, with Scer\GAL4^ey.PH

cv^EP1349

mesonotum, with Scer\GAL4^pnr-MD237

cv^GD3972

mesothoracic tergotrochanter muscle cell

mesothoracic tergotrochanter muscle cell (with cv¹)

cv⁴³

mesothoracic tergotrochanter muscle cell (with cv⁴³)

cv¹

mesothoracic tergotrochanter muscle cell (with Df(1)C149)

cv¹

posterior crossvein

posterior crossvein, with cv⁴³

cv^UAS.cVa

posterior crossvein, with cv^UAS.cVa

cv⁴³

presumptive wing vein | pupal stage

cv⁴³

thoracic adult muscle precursor cell

cv⁴³

wing blade

cv⁷⁰

wing disc | pupal stage

cv⁴³

wing vein

wing vein, with Scer\GAL4^A9

cv^UAS.cVa

wing vein L3

cv¹

wing vein L4

cv¹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\TWSG1

13 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\Twsg1

13 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Twsg1

12 of 14

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\twsg2

11 of 13

Yes

Xtro\twsg1

6 of 13

Danio rerio (Zebrafish) (2)

Drer\twsg1a

12 of 14

Yes

Drer\twsg1b

12 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP000304

11 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:cv. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (3)

tsg

12 of 13

srw

6 of 13

Tbcd

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

TWSG1; twisted gastrulation BMP signaling modulator 1

13 of 14

605049

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

cv - dpp

anti tag coimmunoprecipitation, anti tag western blot

(Shimmi et al., 2005)

cv - gbb

anti tag coimmunoprecipitation, anti tag western blot

(Shimmi et al., 2005)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

tsg

(Shimmi et al., 2005)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

dpp

enhanceable

(Jaramillo et al., 2009)

Gyc76C

suppressible

cv-2|cv|sog

(Schleede and Blair, 2015)

Snr1

enhanceable

(Marenda et al., 2004)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

69095

DroID - A comprehensive database of gene and protein interactions.

FBgn0000394

MIST (genetic) - An integrated Molecular Interaction Database

44510

Pathways

Signaling Pathways (FlyBase)

POSITIVE REGULATORS OF BMP SIGNALING PATHWAY
NEGATIVE REGULATORS OF BMP SIGNALING PATHWAY

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-12

Cytogenetic map

5A13-5A13

Sequence location

X:5,690,002..5,693,084 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

5A13-5A13

Limits computationally determined from genome sequence between P{EP}Tre1^EP496 and P{EP}cv^EP1349&P{EP}CG32758^EP1368

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-12

(FlyBase, 2016)

1-14.4

(Comeron et al., 2012)

1-13.7

(Buzzati-Traverso, 1947)

Right of (cM)

(Marcus, 2003)

l(1)CP9

(Perez-Chiesa et al., 1987)

(Homyk et al., 1986)

Notes

Stocks and Reagents

Stocks (128)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

8693

w¹¹¹⁸ cv¹⁸

8694

w¹¹¹⁸ cv⁴³

606383

w¹¹¹⁸; P{UAS-cv.His6}3

11237

w¹¹¹⁸ P{EP}cv^EP1349

4497

cv¹ v¹ run²⁹/FM6

9165

y¹ cv¹ rux⁴/FM7c

9242

y¹ cv¹ rux⁸/FM7c

Kyoto

107616

y¹ cv¹

101197

w¹ cv¹ sn³

107761

cv¹ v¹ run²⁹/FM6

VDRC

v106311

P{KK108780}VIE-260B

v9729

w¹¹¹⁸; P{GD3972}v9729

More stocks available...

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (33)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD27025

Other clones

DPiM_SD27025

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000394

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000394

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

cv preferentially binds to a dpp/gbb heterodimer, rather than to each protein on its own. Overall orientation not stated: CG3160- cv+ CG3149-

(Shimmi et al., 2005)

Mutations in cv remove transverse veins or crossveins: crossvein specific. Shows additive interactions with vn, ve, ci, cg, shv, ast, H, Vno, vvl, ri, tg, tt and ab.

(Diaz-Benjumea and Garcia-Bellido, 1990)

ri, tg, tt, ab, cv, cv-2, cv-c and cv-d belong to the radius incompletus phenotypic group within the 'lack-of-vein' mutant class. Loss-of-function alleles at these loci remove stretches of veins in two or more longitudinal veins. Double mutants of this group have additive phenotypes suggesting the genes are vein-specific, and have small lanceolate wings. Genes are involved in whole vein region-specification rather than vein differentiation.

(Diaz-Benjumea et al., 1989)

Relationship to Other Genes

Source for database merge of

Source for merge of: cv tsg2

(Marsh, 2001.4.24)

Additional comments

The CG11582 gene may have been derived from the cv gene by retroposition.

(Dai et al., 2006)

Nomenclature History

Source for database identify of

Source for identity of: tsg2 CG12410

(Marsh, 2001.4.10)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG12410

(National Institute of Genetics Fly Stocks, 2023-, Hosono et al., 2015, McEachern et al., 2014, Keleman et al., 2009.8.5, Dai et al., 2006, Shimmi et al., 2005, Tseng and Hariharan, 2002)

(Montanari et al., 2022, Raftery and Umulis, 2012, Serpe et al., 2008)

Tsg2

(Garcia Abreu et al., 2002)

(Beaven and Denholm, 2022, Toddie-Moore et al., 2022, Dubey et al., 2020, Raghuraman et al., 2020, Lovato et al., 2019, Benner and Oliver, 2018, Benner and Oliver, 2018.11.9, Upadhyay et al., 2017, Schleede and Blair, 2015, Cook et al., 2010, Fritsch et al., 2010, Jaramillo et al., 2009, Ma et al., 2008, Serpe et al., 2008, Bonds et al., 2007, Ramos et al., 2006, Verdier et al., 2006)

cv-1

(Garcia Abreu et al., 2002)

tsg2

(O'Connor et al., 2006, Serpe et al., 2006, Shimmi et al., 2005, Shimmi and O'Connor, 2002, Marsh, 2001.4.10, Ross et al., 2001)

Name Synonyms

Crossveinless

(Madamanchi et al., 2021, McEachern et al., 2014, Bonds et al., 2007)

crossvein

(Verdier et al., 2006)

crossveinless

(Cohen et al., 2020, Upadhyay et al., 2017, Costello et al., 2009, Jaramillo et al., 2009, Santos et al., 2005)

twisted gastrulation 2

(Ross et al., 2001)

Secondary FlyBase IDs

FBgn0029790

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 44 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44510

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W494

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9W494

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W494

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000394

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44510/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000394

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000394

FlyMine - An integrated database for Drosophila genomics

FBgn0000394

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG12410

MARRVEL_MODEL - MARRVEL (model organism gene)

44510

Linkouts

BioGRID - A database of protein and genetic interactions.

69095

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000394

DroID - A comprehensive database of gene and protein interactions.

FBgn0000394

DRSC - Results frm RNAi screens

FBgn0000394

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

cv_1
cv_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000394

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000394

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12410

Flygut - An atlas of the Drosophila adult midgut

FBgn0000394

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC003620

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

44510

References (128)

The following external sites may use different assemblies or annotations than FlyBase.

-0.68

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