FlyBase Allele Report: Dmel\cv[43]

General Information

Symbol

Dmel\cv⁴³

Species

D. melanogaster

Name

FlyBase ID

FBal0180273

Feature type

allele

Associated gene

Dmel\cv

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Jaramillo et al., 2009)

Mutagen

Delta2-3 transposase

(Vilmos, 2005, Vilmos et al., 2005)

Progenitor genotype

cv^EP1349

(Vilmos, 2005, Vilmos et al., 2005)

Cytology

Description

Excision of P{EP}cv^EP1349 resulted in generation of a deletion extending from the P-element insertion site past the ATG start site codon to the second intron of cv.

(Vilmos et al., 2005)

Excision of P{EP}cv^EP1349 resulted in generation of a deletion extending from the P-element insertion site past the ATG start site codon to the second intron of cv, approximately 1056bp downstream from the translation start site.

(Vilmos, 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal jumping | partially | recessive

(Jaramillo et al., 2009)

visible

(Fritsch et al., 2010)

visible, with cv^UAS.cVa

(Jaramillo et al., 2009)

visible | recessive

(Jaramillo et al., 2009, Vilmos et al., 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

cv⁴³ mutant pupal wings lack the presumptive posterior crossvein but the organization of the extracellular matrix appears unperturbed.

(Schleede and Blair, 2015)

The number of fibers in the tergal depressor of trochanter (TDT) muscles is reduced in addition to the morphology of these muscles being abnormal in cv¹/cv⁴³ or homozygous cv⁴³ females. The initial specification of TDT founders is normal in cv⁴³ mutants. The first defects in cv⁴³ mutants become apparent at 16 hours after puparium formation (APF), when there are slightly fewer TDT founder cells compared to wild-type.

The posterior crossvein is absent in cv⁴³ mutants.

Jump tests reveal that the jumping distance of hemizygous cv⁴³ males is reduced by about 21% compared to wild-type controls.

(Jaramillo et al., 2009)

cv⁴³ flies exhibit a loss of the anterior and posterior crossveins.

(Vilmos et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

scw^gbb.PF/cv⁴³ is a non-suppressor of visible phenotype of Dp(2;2)DTD48, gbb⁴

(Fritsch et al., 2010)

Phenotype Manifest In

Enhancer of

Statement

Reference

cv[+]/cv⁴³ is an enhancer of mesothoracic tergotrochanter muscle cell phenotype of dpp¹⁰⁶³⁸

(Jaramillo et al., 2009)

NOT Suppressor of

Statement

Reference

scw^gbb.PF/cv⁴³ is a non-suppressor of posterior crossvein phenotype of Dp(2;2)DTD48, gbb⁴

(Fritsch et al., 2010)

Other

Statement

Reference

+/Df(2R)BSC136, cv⁴³ has mesothoracic tergotrochanter muscle cell phenotype

(Jaramillo et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The ability of scw^gbb.PF to rescue the loss of posterior crossvein which is seen in Dp(2;2)DTD48, gbb⁴/gbb⁴ flies is completely suppressed in a cv⁴³ background.

(Fritsch et al., 2010)

The weak dpp¹⁰⁶³⁸/+ tergal depressor of trochanter (TDT) muscle phenotype is enhanced by cv⁴³/+, because the TDT fiber count is further reduced relative to dpp¹⁰⁶³⁸/+ single heterozygotes.

The combination of cv⁴³/+ and Df(2R)BSC136/+ results in significant reductions in TDT fiber numbers.

(Jaramillo et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

cv⁴³ is partially rescued by Scer\GAL4^how-24B/cv^UAS.cVa

(Jaramillo et al., 2009)

cv⁴³ is partially rescued by Scer\GAL4^ptc-559.1/cv^UAS.cVa

(Jaramillo et al., 2009)

cv⁴³ is partially rescued by cv^UAS.cVa

(Jaramillo et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8694

w¹¹¹⁸ cv⁴³

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

cv⁴³

(Schleede and Blair, 2015, Fritsch et al., 2010, Jaramillo et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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