FlyBase Allele Report: Dmel\cv[70]

General Information

Symbol

Dmel\cv⁷⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0190940

Feature type

allele

Associated gene

Dmel\cv

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Shimmi et al., 2005)

Progenitor genotype

P{EP}cv^EP1349

(Shimmi et al., 2005)

Cytology

Description

Imprecise excision of the P{EP} element starting at the insertion point of P{EP}cv^EP1349 and finishing in the second intron of cv. This removes the translational start site and the first coding exon.

(Shimmi et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Shimmi et al., 2005)

visible

(Schleede and Blair, 2015)

Phenotype Manifest In

crossvein

(Shimmi et al., 2005)

posterior crossvein

(Schleede and Blair, 2015)

wing blade

(Schleede and Blair, 2015)

wing vein

(Shimmi et al., 2005)

Detailed Description

Statement

Reference

cv⁷⁰ mutants show complete loss of posterior crossvein in adult wings.

(Schleede and Blair, 2015)

Both the anterior and posterior crossveins are missing in the wings of cv⁷⁰ flies and the longitudinal veins are expanded.

(Shimmi et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

cv⁷⁰ has visible phenotype, non-suppressible by Gyc76C^UAS.Tag:MYC/Scer\GAL4^en.PU

(Schleede and Blair, 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

cv⁷⁰ has crossvein phenotype, suppressible by tsg^{UAS.Tag:polyHis}/Scer\GAL4^arm.PS

(Shimmi et al., 2005)

NOT suppressed by

Statement

Reference

cv⁷⁰ has wing blade phenotype, non-suppressible by Gyc76C^UAS.Tag:MYC/Scer\GAL4^en.PU

(Schleede and Blair, 2015)

cv⁷⁰ has posterior crossvein phenotype, non-suppressible by Gyc76C^UAS.Tag:MYC/Scer\GAL4^en.PU

(Schleede and Blair, 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The complete loss of the wing posterior crossvein in cv⁷⁰ hemizygous adults cannot be reverted by expression of Gyc76C^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^en.PU (which on its own leads to ectopic venation).

(Schleede and Blair, 2015)

Expression of tsg^{Scer\UAS.T:Zzzz\His6}, under the control of Scer\GAL4^arm.PS, suppresses the crossveinless phenotype of cv⁷⁰ mutants. The extent of the suppression is dependent on the insertion line of tsg^{Scer\UAS.T:Zzzz\His6}, but some lines achieve complete rescue.

(Shimmi et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

cv¹

(Shimmi et al., 2005)

Rescued by

cv⁷⁰ is rescued by Scer\GAL4^arm.PS/cv^{UAS.Tag:polyHis}

(Shimmi et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

cv⁷⁰

(Schleede and Blair, 2015, Matsuda et al., 2013, Matsuda and Shimmi, 2012, Serpe et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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