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General Information
Name
Wnt-TCF Signaling Pathway Core Components
Species
D. melanogaster
Symbol
WNT-TCFC
FlyBase ID
FBgg0000890
Date last reviewed
2019-11-14
Number of members
11
Description
Description
The canonical Wnt signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes. (Adapted from FBrf0218499 and FBrf0223299).
Notes and selected reviews

The core canonical Wnt signaling pathway components are defined as those that are required in the activated pathway for β-catenin (arm) to function in regulating of transcription of target genes.

Biological Process Gene Ontology (GO) term(s)
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Protein Complex group(s)
Other related group(s)
Physical Interaction Network
Members (11)
For all members:
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
Wnt-TCF Signaling Pathway Core Components
Canonical Wnt Signaling Pathway Core Components
WNT-TCFC
WNT-CANC
Secondary FlyBase ID(s)
References (49)