The canonical Wnt signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes. (Adapted from FBrf0218499 and FBrf0223299).
Notes and selected reviews
The core canonical Wnt signaling pathway components are defined as those that are required in the activated pathway for β-catenin (arm) to function in regulating of transcription of target genes.