FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Pathway: WNT-TCF SIGNALING PATHWAY
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General Information
Name
WNT-TCF SIGNALING PATHWAY
Species
D. melanogaster
Symbol
WNT-TCF
FlyBase ID
FBgg0000889
Date last reviewed
2025-06-11
Number of members
102
Description
Description
The Wnt-TCF (canonical Wnt) signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. In the absence of a Wnt ligand, cytoplasmic levels of β-catenin (arm), the transcriptional effector of the pathway, are kept low through its constitutive degradation. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes. (Adapted from FBrf0218499 and FBrf0223299).
Notes and selected reviews

Selected publications for background information: Modulating and measuring Wingless signalling (FBrf0225263), Powerful Drosophila screens that paved the wingless pathway (FBrf0228944), Function of the Wingless Signaling Pathway in Drosophila (FBrf0206499), The wingless signalling pathway and the patterning of the wing margin in Drosophila (FBrf0072872), Wnt/Wingless Signaling in Drosophila (FBrf0218499) and Wingless/Wnt signaling in Drosophila: the pattern and the pathway (FBrf0223299).

Biological Process Gene Ontology (GO) term(s)
Wnt signaling pathway
Related Gene Groups
Component group(s)
NEGATIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY
POSITIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY
WNT PRODUCTION
WNT-TCF SIGNALING PATHWAY CORE COMPONENTS
Physical Interaction Network
Members (102)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Other resource(s)

[The Wnt homepage](http://web.stanford.edu/group/nusselab/cgi-bin/wnt/)

[The Wnt homepage - Reagents to study Wnt signaling (cross-species)](http://web.stanford.edu/group/nusselab/cgi-bin/wnt/reagents)

[Gene List - Genes downstream of wingless (The Interactive Fly)](http://www.sdbonline.org/sites/fly/aignfam/sgmtplty.htm#Wingless)

[KEGG pathway - Wnt signaling pathway - Drosophila melanogaster](https://www.kegg.jp/entry/pathway/dme04310)

[The Wnt homepage - Reagents to detect and activate Wnt signaling (cross-species)](http://web.stanford.edu/group/nusselab/cgi-bin/wnt/activators_detectors)

[Illustration - Canonical Wnt signaling pathway in Drosophila (The Interactive Fly)](http://www.sdbonline.org/sites/fly/pathway/aapathway2.htm#Wg1)

[Illustration - The role of negative feedback inhibitors in Wingless (Wg) signaling (The Interactive Fly)](http://www.sdbonline.org/sites/fly/pathway/aapathway2.htm#Wg2)

[Wikipathways - Wnt Signaling Pathway (Drosophila melanogaster)](https://www.wikipathways.org/index.php/ Pathway:WP97 )

[Animation - The Wnt/β-catenin signaling pathway (Wolpert, Tickle & Martinez Arias:Principles of Development International 5e)](http://youtu.be/oweNT288BXo)

[Reactome Pathway - WG ligand not bound to FZ receptors](https://reactome.org/PathwayBrowser/#/R-DME-209412&SEL=R-DME-209441&PATH=R-DME-5252538)

[Reactome Pathway - WG ligand bound to FZ receptors](https://reactome.org/PathwayBrowser/#/R-DME-209412&SEL=R-DME-209469&PATH=R-DME-5252538)

Synonyms and Secondary IDs
Synonym(s)
wg signaling pathway
Wnt/β-catenin pathway
Canonial Wnt Signaling Pathway
Canonical Wnt Signaling Pathway
WNT-TCF
WNT-CAN
WNT-TCF SIGNALING PATHWAY
Wnt-TCF Signaling Pathway
Secondary FlyBase ID(s)
References (167)