Ewen-Campen, B., Mohr, S.E., Hu, Y., Perrimon, N. (2017). Accessing the Phenotype Gap: Enabling Systematic Investigation of Paralog Functional Complexity with CRISPR. Dev. Cell 43(1): 6--9.
FlyBase ID
FBrf0236913
Publication Type
Review
Abstract
Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype gap" and impact biomedical research.
