FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Wnt6
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General Information
Symbol
Dmel\Wnt6
Species
D. melanogaster
Name
Wnt oncogene analog 6
Annotation Symbol
CG4969
Feature Type
protein_coding_gene
FlyBase ID
FBgn0031902
Gene Model Status
Current
Stock Availability
27 publicly available
Gene Summary
Wnt oncogene analog 6 (Wnt6) encodes a member of the Wnt family that can activate canonical Wnt signaling. It is expressed in the dorsal/ventral boundary of the wing and the maxillary palp. It contributes to maxillary palp formation. [Date last reviewed: 2018-11-15] (FlyBase Gene Snapshot)
All Summaries
Also Known As

DWnt6

Key Links
Genomic Location
Cytogenetic map
27F1-27F2
Sequence location
Recombination map
2-26
RefSeq locus
NT_033779 REGION:7333714..7352542
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables cytokine activity
inferred from biological aspect of ancestor with PANTHER:PTN000246517
(GO Reference Genome Project, 2011-)
enables frizzled binding
inferred from biological aspect of ancestor with PANTHER:PTN000246517
(GO Reference Genome Project, 2011-)
enables signaling receptor binding
inferred from sequence or structural similarity with FLYBASE:wg; FB:FBgn0284084
(Gene Ontology Curators, 2002-)
inferred from electronic annotation with InterPro:IPR005817, InterPro:IPR009143
(InterPro Project Members, 2004-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in canonical Wnt signaling pathway
inferred from direct assay
(Doumpas et al., 2013)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in canonical Wnt signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000246517
(GO Reference Genome Project, 2011-)
involved_in cell fate commitment
inferred from biological aspect of ancestor with PANTHER:PTN000246517
(GO Reference Genome Project, 2011-)
involved_in neuron differentiation
inferred from biological aspect of ancestor with PANTHER:PTN000246517
(GO Reference Genome Project, 2011-)
involved_in Wnt signaling pathway
inferred from electronic annotation with InterPro:IPR005817, InterPro:IPR009143
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with FLYBASE:wg; FB:FBgn0284084
(Gene Ontology Curators, 2002-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in extracellular region
inferred from electronic annotation with InterPro:IPR005817, InterPro:IPR009143
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with FLYBASE:wg; FB:FBgn0284084
(Gene Ontology Curators, 2002-)
is_active_in extracellular space
inferred from biological aspect of ancestor with PANTHER:PTN000246517
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Wnt oncogene analog 6 (Wnt6) encodes a member of the Wnt family that can activate canonical Wnt signaling. It is expressed in the dorsal/ventral boundary of the wing and the maxillary palp. It contributes to maxillary palp formation. [Date last reviewed: 2018-11-15]
Gene Group (FlyBase)
WNTs -
WNTs are evolutionarily conserved secreted Cys-rich glycoproteins, defined by sequence homology to the original members of the family - Wnt1 in mouse and wingless (wg) in Drosophila. They are extracellular ligands for members of the Frizzled family of receptors as well as other receptors. (Adapted from PMID:23151663).
Pathway (FlyBase)
WNT-TCF SIGNALING PATHWAY CORE COMPONENTS -
The canonical Wnt signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes. (Adapted from FBrf0218499 and FBrf0223299).
Summary (Interactive Fly)

required for maxillary palp formation - oogenesis - anterior escort cells are maintained by Wnt6 signaling - required for germline stem cell maintenance

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Wnt6 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VM26)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Wnt6-RB
FBtr0303251
NM_135264
2855
420
Wnt6-RC
FBtr0334800
NM_001273259
2837
420
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Wnt6-PB
FBpp0292343
47.8
420
10.14
Q9VM26
NP_609108
AAF52502
Wnt6-PC
FBpp0306846
47.8
420
10.14
Q9VM26
NP_001260188
AGB92724
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

420 aa isoforms: Wnt6-PB, Wnt6-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Wnt6 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.06

Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Wnt6 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 24 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Wnt6
Transgenic constructs containing regulatory region of Wnt6
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2L)Exel6017
(Ryder, 2004.4.26)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (19)
Hsap\WNT6
11 of 14
Yes
Yes
Hsap\WNT1
3 of 14
No
No
1  
Hsap\WNT8B
3 of 14
No
No
Hsap\WNT16
3 of 14
No
No
Hsap\WNT2B
2 of 14
No
No
Hsap\WNT2
2 of 14
No
No
Hsap\WNT3A
2 of 14
No
No
Hsap\WNT3
2 of 14
No
No
Hsap\WNT4
2 of 14
No
No
Hsap\WNT5A
2 of 14
No
No
Hsap\WNT5B
2 of 14
No
No
Hsap\WNT7A
2 of 14
No
No
1  
Hsap\WNT7B
2 of 14
No
No
1  
Hsap\WNT8A
2 of 14
No
No
Hsap\WNT9A
2 of 14
No
No
1  
Hsap\WNT9B
2 of 14
No
No
1  
Hsap\WNT10A
2 of 14
No
No
1  
Hsap\WNT10B
2 of 14
No
No
1  
Hsap\WNT11
2 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (19)
Rnor\Wnt6
11 of 14
Yes
Yes
Rnor\Wnt16
3 of 14
No
No
Rnor\Wnt1
2 of 14
No
No
Rnor\Wnt2b
2 of 14
No
No
Rnor\Wnt3a
2 of 14
No
No
Rnor\Wnt3
2 of 14
No
No
Rnor\Wnt4
2 of 14
No
No
Rnor\Wnt5a
2 of 14
No
No
Rnor\Wnt5b
2 of 14
No
No
Rnor\Wnt7a
2 of 14
No
No
Rnor\Wnt7b
2 of 14
No
No
Rnor\Wnt8b
2 of 14
No
No
Rnor\Wnt11
2 of 14
No
No
Rnor\Wnt2
1 of 14
No
No
Rnor\Wnt8a
1 of 14
No
No
Rnor\Wnt9a
1 of 14
No
No
Rnor\Wnt9b
1 of 14
No
No
Rnor\Wnt10a
1 of 14
No
No
Rnor\Wnt10b
1 of 14
No
No
Mus musculus (laboratory mouse) (18)
Mmus\Wnt6
11 of 14
Yes
Yes
Mmus\Wnt1
3 of 14
No
No
Mmus\Wnt16
3 of 14
No
No
Mmus\Wnt2b
2 of 14
No
No
Mmus\Wnt2
2 of 14
No
No
Mmus\Wnt3a
2 of 14
No
No
Mmus\Wnt3
2 of 14
No
No
Mmus\Wnt4
2 of 14
No
No
Mmus\Wnt5a
2 of 14
No
No
Mmus\Wnt7a
2 of 14
No
No
Mmus\Wnt7b
2 of 14
No
No
Mmus\Wnt8b
2 of 14
No
No
Mmus\Wnt10a
2 of 14
No
No
Mmus\Wnt10b
2 of 14
No
No
Mmus\Wnt11
2 of 14
No
No
Mmus\Wnt5b
1 of 14
No
No
Mmus\Wnt8a
1 of 14
No
No
Mmus\Wnt9b
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (20)
Xtro\wnt6
6 of 13
Yes
Yes
Xtro\wnt1
2 of 13
No
No
Xtro\ccdc78
1 of 13
No
Yes
Xtro\chmp4c
1 of 13
No
No
Xtro\gstk1
1 of 13
No
Yes
Xtro\LOC493495
1 of 13
No
No
Xtro\LOC100487954
1 of 13
No
No
Xtro\mafa
1 of 13
No
No
Xtro\nek9
1 of 13
No
No
Xtro\nthl1
1 of 13
No
No
Xtro\syt3
1 of 13
No
No
Xtro\wnt2
1 of 13
No
No
Xtro\wnt3a
1 of 13
No
No
Xtro\wnt3
1 of 13
No
No
Xtro\wnt5a
1 of 13
No
No
Xtro\wnt8a
1 of 13
No
No
Xtro\wnt9b
1 of 13
No
No
Xtro\wnt10b
1 of 13
No
No
Xtro\wnt11b
1 of 13
No
No
Xtro\wnt11
1 of 13
No
No
Danio rerio (Zebrafish) (25)
Drer\wnt6b
14 of 14
Yes
Yes
Drer\wnt6a
12 of 14
No
Yes
Drer\LOC568110
3 of 14
No
No
Drer\wnt2ba
3 of 14
No
No
Drer\wnt2bb
3 of 14
No
No
Drer\wnt7aa
3 of 14
No
No
Drer\wnt7ba
3 of 14
No
No
Drer\wnt7bb
3 of 14
No
No
Drer\wnt16
3 of 14
No
No
Drer\wnt1
2 of 14
No
No
Drer\wnt2
2 of 14
No
No
Drer\wnt3a
2 of 14
No
No
Drer\wnt3
2 of 14
No
No
Drer\wnt4
2 of 14
No
No
Drer\wnt8b
2 of 14
No
No
Drer\wnt10a
2 of 14
No
No
Drer\wnt10b
2 of 14
No
No
Drer\wnt11f2
2 of 14
No
No
Drer\wnt4b
1 of 14
No
No
Drer\wnt5a
1 of 14
No
No
Drer\wnt5b
1 of 14
No
No
Drer\wnt8a
1 of 14
No
No
Drer\wnt9a
1 of 14
No
No
Drer\wnt9b
1 of 14
No
No
Drer\wnt11
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\mom-2
3 of 14
Yes
No
Cele\cwn-2
2 of 14
No
No
Cele\egl-20
2 of 14
No
No
Cele\cwn-1
1 of 14
No
No
Cele\lin-44
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (8)
Agam\AgaP_AGAP009733
12 of 12
Yes
Yes
Agam\AgaP_AGAP009731
3 of 12
No
No
Agam\AgaP_AGAP009734
3 of 12
No
No
Agam\AgaP_AGAP010283
3 of 12
No
No
Agam\AgaP_AGAP008678
2 of 12
No
No
Agam\AgaP_AGAP009732
2 of 12
No
Yes
Agam\AgaP_AGAP009735
2 of 12
No
No
Agam\AgaP_AGAP010290
2 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Wnt6. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (6)
wg
5 of 13
Wnt2
5 of 13
Wnt4
5 of 13
Wnt10
5 of 13
Wnt5
4 of 13
wntD
3 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    WNT6; Wnt family member 6
    11 of 14
    604663
        WNT1; Wnt family member 1
        3 of 14
        164820
         
        WNT8B; Wnt family member 8B
        3 of 14
        601396
            WNT16; Wnt family member 16
            3 of 14
            606267
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                Summary of Genetic Interactions
                Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                dlp
                suppressible
                Wnt6
                (Waghmare et al., 2020)
                Wnt2|wg
                suppressible
                Wnt6
                (Llimargas and Lawrence, 2001)
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                FlyBase
                External Links
                External Data
                Linkouts
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Class of Gene
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                2L
                Recombination map
                2-26
                Cytogenetic map
                27F1-27F2
                Sequence location
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                27F1-27F2
                ; Limits computationally determined from genome sequence between P{PZ}wg02657 and P{EP}EP787EP787
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                Experimentally Determined Recombination Data
                Location

                2-26

                (FlyBase, 2016)

                2-24.1

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (27)
                Genomic Clones (15)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (6)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                  Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                    Other clones
                    RNAi and Array Information
                    Linkouts
                    DRSC - Results frm RNAi screens
                    Antibody Information
                    Laboratory Generated Antibodies
                     
                    Commercially Available Antibodies
                     
                    Cell Line Information
                    Publicly Available Cell Lines
                     
                      Other Stable Cell Lines
                       
                        Other Comments

                        Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.

                        (Liu and Lehmann, 2008)

                        Expression is enriched in embryonic gonads.

                        (Shigenobu et al., 2006)
                        Relationship to Other Genes
                        Source for database merge of
                        Additional comments
                        Nomenclature History
                        Source for database identify of

                        Source for identity of: Wnt6 CG4969

                        (Llimargas, 2002.6.3)
                        Nomenclature comments
                        Etymology
                        Synonyms and Secondary IDs (9)
                        Reported As
                        Symbol Synonym
                        CG4969
                        (National Institute of Genetics Fly Stocks, 2022-, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009)
                        D-Wnt-6
                        (Chen et al., 2008)
                        DWnt-6
                        (Llimargas, 2002.6.3)
                        DWnt6
                        (Yu et al., 2020, Coudreuse and Korswagen, 2007, Bajpai et al., 2004, Janson et al., 2001, Llimargas and Lawrence, 2001)
                        Dwnt-6
                        (Swarup and Verheyen, 2012)
                        Dwnt6
                        (Perochon et al., 2018)
                        Wnt6
                        (Chen et al., 2024, Cui et al., 2024, Goins et al., 2024, Floc'hlay et al., 2023, Suyama et al., 2023, Deshpande et al., 2022, Majane et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Worley and Hariharan, 2022, Destalminil-Letourneau et al., 2021, Everetts et al., 2021, Joy et al., 2021, Slaidina et al., 2021, Wang et al., 2021, Holzem et al., 2020, Kizhedathu et al., 2020, Rushton et al., 2020, Rust et al., 2020, Waghmare et al., 2020, Zhang and Cai, 2020, Hall et al., 2019, Gene Disruption Project members, 2018-, Tian et al., 2018, Waghmare and Page-McCaw, 2018, Transgenic RNAi Project members, 2017-, Harris et al., 2016, Koshikawa et al., 2015, Lee et al., 2015, Djiane et al., 2013, Doumpas et al., 2013, Zhang et al., 2013, Herr and Basler, 2012, Chen et al., 2008, Liu and Lehmann, 2008, Zdobnov and Bork, 2007, Casal et al., 2006, Shigenobu et al., 2006, Tolhuis et al., 2006)
                        wnt6
                        (Chen et al., 2022, Gracia-Latorre et al., 2022, Ewen-Campen et al., 2020, Jia et al., 2018, Ikmi et al., 2014, Glise et al., 2005)
                        Name Synonyms
                        Wnt oncogene analog 6
                        Wnt6
                        Secondary FlyBase IDs
                          Datasets (0)
                          Study focus (0)
                          Experimental Role
                          Project
                          Project Type
                          Title
                          Study result (0)
                          Result
                          Result Type
                          Title
                          External Crossreferences and Linkouts ( 35 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                          Other crossreferences
                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                          FlyMine - An integrated database for Drosophila genomics
                          InterPro - A database of protein families, domains and functional sites
                          KEGG Genes - Molecular building blocks of life in the genomic space.
                          MARRVEL_MODEL - MARRVEL (model organism gene)
                          Linkouts
                          BioGRID - A database of protein and genetic interactions.
                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                          DroID - A comprehensive database of gene and protein interactions.
                          DRSC - Results frm RNAi screens
                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                          Flygut - An atlas of the Drosophila adult midgut
                          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                          MIST (protein-protein) - An integrated Molecular Interaction Database
                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                          References (101)