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General Information
Symbol
Dmel\dlp2
Species
D. melanogaster
Name
FlyBase ID
FBal0191142
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

dlp1/dlp2 larvae have a normal number of boutons at the neuromuscular junction. Mean active zone area is significantly decreased and the number of active zones per bouton is significantly increased compared to wild type.

The amplitude of the evoked excitatory junctional potential (EJP) is increased compared to wild type at the neuromuscular junction of dlp1/dlp2 larvae. The amplitude and frequency of miniature EJPs is normal. Quantal content is increased.

 :dlp1/dlp2 mutants show axon guidance defects. At the third instar larval stage, ~30% of mutants show thickening of the lamina plexus, and >60% show crossovers between ommatidial axon bundles and abnormal photoreceptor process expansion outside the lamina plexus. At the pupal level, 80% of dlp1/dlp2 mutants have brains with irregularities in the R7 and R8 medulla termini and over 20% show medulla cartridge crossover. The differentiation of dlp1/dlp2 photoreceptors is not defective.

Less than 5% of dlp2 mutants survive to adulthood. dlp1/dlp2 embryos from dlp1 germline clone females and dlp2 males show a severe segment polarity defect with denticles covering the ventral surface. dlp1/dlp2 escapers show patterning defects at the anterior margin, with ectopic mechanosensory bristles on both dorsal and ventral surfaces, that are positioned further from the wing margin than bristles in wild type. This phenotype is fully penetrant, but the number of ectopic bristles varies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

dlp[+]/dlp2 is a suppressor of increased cell number | female | adult stage | heat sensitive phenotype of Df(2R)BSC132/Mmp2Y53N

dlp[+]/dlp2 is a suppressor of increased cell number | female | adult stage | heat sensitive phenotype of Mmp2Y53N/Mmp2W307stop

Phenotype Manifest In
NOT suppressed by
Statement
Reference

dlp1/dlp2 has eye photoreceptor cell & axon phenotype, non-suppressible by SdcUAS.cSa/Scer\GAL4da.G32

Suppressor of
Statement
Reference

dlp[+]/dlp2 is a suppressor of stalk follicle cell | supernumerary | heat sensitive phenotype of Df(2R)BSC132/Mmp2Y53N

dlp[+]/dlp2 is a suppressor of stalk follicle cell | supernumerary | heat sensitive phenotype of Mmp2Y53N/Mmp2W307stop

Other
Additional Comments
Genetic Interactions
Statement
Reference

The increase in average cell number in the stalks between egg chambers which is seen in Mmp2Y53N/Df(2R)BSC132 and Mmp2Y53N/Mmp2W307stop females after being shifted to the restrictive temperature is dominantly suppressed if the females also carry a single copy of dlp2.

Expression of SdcScer\UAS.cSa, under the control of Scer\GAL4da.G32, fails to rescue the axon guidance defects of dlp1/dlp2 mutants.

dlp2 +/+ Notum3 transheterozygotes show increased bristle density at the anterior wing margin and ectopic bristles positioned further from the wing margin than in wild type. Neither dlp2/+ or Notum3/+ single mutant flies show this phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: lethal over Df(3L)dlpex15.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)