FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\cmpy
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General Information
Symbol
Dmel\cmpy
Species
D. melanogaster
Name
crimpy
Annotation Symbol
CG13253
Feature Type
protein_coding_gene
FlyBase ID
FBgn0037015
Gene Model Status
Current
Stock Availability
31 publicly available
Gene Summary
cysteine-rich transmembrane BMP regulator - physically interacts with and inhibits BMP ligand glass bottom boat in motoneurons thus permitting the muscle-derived Gbb pool to predominate at the NMJ and establishing the retrograde directionality of the pro-growth BMP pathway (Interactive Fly, cmpy )
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
77E3-77E3
Sequence location
Recombination map
3-47
RefSeq locus
NT_037436 REGION:20712838..20719200
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables BMP binding
inferred from genetic interaction with FLYBASE:gbb; FB:FBgn0024234
(James et al., 2014)
inferred from physical interaction with FLYBASE:gbb; FB:FBgn0024234
(James and Broihier, 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables insulin-like growth factor binding
inferred from electronic annotation with InterPro:IPR011390
(InterPro Project Members, 2004-)
enables receptor ligand activity
inferred from biological aspect of ancestor with PANTHER:PTN001021372
(GO Reference Genome Project, 2011-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in negative regulation of BMP signaling pathway
inferred from genetic interaction with FLYBASE:Mad; FB:FBgn0011648
(James and Broihier, 2011)
inferred from genetic interaction with FLYBASE:wit; FB:FBgn0024179
(James and Broihier, 2011)
inferred from genetic interaction with FLYBASE:gbb; FB:FBgn0024234
(James and Broihier, 2011)
involved_in neuromuscular junction development
inferred from mutant phenotype
(James and Broihier, 2011)
involved_in positive regulation of BMP signaling pathway
inferred from mutant phenotype
(James et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in regulation of cell growth
inferred from electronic annotation with InterPro:IPR011390
(InterPro Project Members, 2004-)
involved_in regulation of signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN001021372
(GO Reference Genome Project, 2011-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in dense core granule
inferred from direct assay
(James et al., 2014)
located_in extracellular space
inferred from direct assay
(James et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in extracellular region
inferred from electronic annotation with InterPro:IPR000867, InterPro:IPR011390
(InterPro Project Members, 2004-)
is_active_in extracellular space
inferred from biological aspect of ancestor with PANTHER:PTN001021372
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Pathway (FlyBase)
NEGATIVE REGULATORS OF BMP SIGNALING PATHWAY -
Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.
POSITIVE REGULATORS OF BMP SIGNALING PATHWAY -
Positive regulators of Bone Morphogenetic Protein (BMP) signaling up-regulate the pathway, ultimately resulting in the increased nuclear activity of the Mad/Med transcription factor complex.
Summary (Interactive Fly)

cysteine-rich transmembrane BMP regulator - physically interacts with and inhibits BMP ligand glass bottom boat in motoneurons thus permitting the muscle-derived Gbb pool to predominate at the NMJ and establishing the retrograde directionality of the pro-growth BMP pathway

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\cmpy for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A8JNW3)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
cmpy-RB
FBtr0113182
NM_001104181
2737
116
cmpy-RC
FBtr0113183
NM_001104182
1622
273
cmpy-RD
FBtr0305579
NM_001259920
1638
273
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
cmpy-PB
FBpp0112095
12.7
116
10.28
Q9VPC5
NP_001097651
AAF51630
cmpy-PC
FBpp0112096
30.4
273
8.73
A8JNW3
NP_001097652
ABW08575
cmpy-PD
FBpp0294030
30.4
273
8.73
A8JNW3
NP_001246849
AFH04520
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

273 aa isoforms: cmpy-PC, cmpy-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cmpy using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.58

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 14
larval ventral nerve cord | restricted
(James and Broihier, 2011)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic stage 14
RP neuron | subset
(James and Broihier, 2011)
larval EL neuron | subset
(James and Broihier, 2011)
Additional Descriptive Data

At embryonic stage 14 cmpy transcripts are expressed in a subset of hb positive neurons of the ventral nerve cord including ventrally projecting RP neurons and dorsally projecting EL neurons.

(James and Broihier, 2011)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in dense core granule
inferred from direct assay
(James et al., 2014)
located_in extracellular space
inferred from direct assay
(James et al., 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\cmpy in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of cmpy
Transgenic constructs containing regulatory region of cmpy
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene partially disrupted in
Df(3L)cmpyΔ8
(James and Broihier, 2011)
Inferred from location ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (8)
Hsap\CCN1
1 of 14
Yes
No
Hsap\CCN2
1 of 14
Yes
No
2  
Hsap\CCN3
1 of 14
Yes
No
Hsap\CCN4
1 of 14
Yes
No
Hsap\CCN5
1 of 14
Yes
No
1  
Hsap\CCN6
1 of 14
Yes
No
Hsap\CRIM1
1 of 14
Yes
No
Hsap\ESM1
1 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (8)
Rnor\Ccn1
1 of 14
Yes
No
Rnor\Ccn2
1 of 14
Yes
No
Rnor\Ccn3
1 of 14
Yes
No
Rnor\Ccn4
1 of 14
Yes
No
Rnor\Ccn5
1 of 14
Yes
No
Rnor\Ccn6
1 of 14
Yes
No
Rnor\Crim1
1 of 14
Yes
No
Rnor\Esm1
1 of 14
Yes
Yes
Mus musculus (laboratory mouse) (7)
Mmus\Ccn1
1 of 14
Yes
No
Mmus\Ccn2
1 of 14
Yes
No
Mmus\Ccn3
1 of 14
Yes
No
Mmus\Ccn4
1 of 14
Yes
No
Mmus\Ccn5
1 of 14
Yes
No
Mmus\Ccn6
1 of 14
Yes
No
Mmus\Crim1
1 of 14
Yes
No
Xenopus tropicalis (Western clawed frog) (11)
Xtro\ccn1
1 of 13
Yes
No
Xtro\ccn2
1 of 13
Yes
No
Xtro\ccn3
1 of 13
Yes
No
Xtro\ccn4
1 of 13
Yes
No
Xtro\ccn5
1 of 13
Yes
No
Xtro\ccn6
1 of 13
Yes
No
Xtro\crim1
1 of 13
Yes
Yes
Xtro\esm1
1 of 13
Yes
Yes
Xtro\LOC101731600
1 of 13
Yes
Yes
Xtro\pcyox1
1 of 13
Yes
No
Xtro\rita1
1 of 13
Yes
Yes
Danio rerio (Zebrafish) (13)
Drer\si:ch73-330k17.3
2 of 14
Yes
Yes
Drer\ccn1
1 of 14
No
No
Drer\ccn1l1
1 of 14
No
No
Drer\ccn1l2
1 of 14
No
No
Drer\ccn2a
1 of 14
No
No
Drer\ccn2b
1 of 14
No
No
Drer\ccn4a
1 of 14
No
No
Drer\ccn4b
1 of 14
No
No
Drer\ccn5
1 of 14
No
No
Drer\ccn6
1 of 14
No
No
Drer\crim1
1 of 14
No
No
Drer\esm1
1 of 14
No
Yes
Drer\si:ch211-106h11.3
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP006908
1 of 12
Yes
No
Agam\OEH
1 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:cmpy. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (1)
Ccn
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    cmpy - gbb
    anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot, two hybrid
    (James et al., 2014, James and Broihier, 2011)
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    cmpy
    suppressible
    gbb
    (James and Broihier, 2011)
    cmpy
    suppressible
    Mad
    (James and Broihier, 2011)
    cmpy
    suppressible
    wit
    (James and Broihier, 2011)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    gbb
    suppressible
    cmpy
    (James and Broihier, 2011)
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-47
    Cytogenetic map
    77E3-77E3
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    77E3-77E3
    Limits computationally determined from genome sequence between P{EP}trblEP3519 and P{EP}fngEP3082&P{lacW}skdL7062
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    3-47

    (FlyBase, 2016)

    3-43.7

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (31)
    Genomic Clones (39)
    cDNA Clones (43)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        cmpy delivers gbb protein to dense core vesicles for activity-dependent release at the neuromuscular junction. The cmpy ectodomain is secreted following nerve depolarisation, suggesting that it may have a second function in gbb signaling at the neuromuscular junction.

        (James et al., 2014)
        Relationship to Other Genes
        Source for database merge of
        Additional comments
        Nomenclature History
        Source for database identify of

        Source for identity of: cmpy CG13253

        (James and Broihier, 2011)
        Nomenclature comments
        Etymology

        Named 'crimpy' based on the sequence similarity to vertebrate 'Crim1' and the observation that mutants have numerous small boutons that are reminiscent of a type of rock climbing route featuring small holds, or crimps, which can be described as a 'crimpy' route.

        (James and Broihier, 2011)
        Synonyms and Secondary IDs (5)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 37 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        MIST (protein-protein) - An integrated Molecular Interaction Database
        References (28)