receptor s/t kinase - a type I Dpp receptor - necessary for the specification of the dorsal-most cell fate (amnioserosa) which requires the highest levels of Dpp activity - together with the BMP receptors Tkv and Put, Sax transduces signaling of the BMP ligands Dpp, Gbb and Scw in the embryo and in imaginal disc patterning
Gene model reviewed during 5.40
Gene model reviewed during 5.49
3 (northern blot)
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sax using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\sax in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: sax CG1891
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
sax protein participates in the determination of the anterior posterior margin fate in the developing wing pouch, even at the extreme anterior edge. sax and tkv interact with the same developmental pathways required for proper anterior posterior patterning of the wing.
Specification of distinct cell fates in response to different concentrations of dpp product may be achieved combinatorially by the sax and tkv receptors. sax is required for the specification of the amnioserosa.
Isolated in a PCR screen for receptor protein serine/threonine kinase candidates.