FB2026_03 , released September 17, 2026
Gene Group: TGF-BETA TYPE I RECEPTORS
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General Information
Name
TGF-BETA TYPE I RECEPTORS
Species
D. melanogaster
Symbol
TGF-RI
FlyBase ID
FBgg0001096
Date last reviewed
2019-05-08
Number of members
3
Description
Description
The Transforming Growth Factor-β Receptor (TGF-βR) family are transmembrane serine/threonine kinases. They form heterodimeric receptor complexes composed of type I and type II subunits. Upon ligand binding, the constitutively active type II receptor phosphorylates the type I receptor which, in turn, phosphorylates a member of the Smad family. (Adapted from FBrf0236482.)
Notes on Group
Source Material
The TGF-BETA TYPE I RECEPTORS Gene Group has been compiled using the following publication(s): Sopko et al., 2014, Vogel et al., 2013, Manning et al., 2002, and Morrison et al., 2000 .
Key Gene Ontology (GO) terms
Molecular Function
transmembrane receptor protein serine/threonine kinase activity
Biological Process
cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
plasma membrane
Enzymatic activity
Enzyme name (EC)
receptor protein serine/threonine kinase (2.7.11.30)
Related Gene Groups
Parent group(s)
TGF-BETA RECEPTOR FAMILY
Members (3)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
TGF-RI
TGF-BETA TYPE I RECEPTORS
TGF-β Type I Receptor Family
Type 1 receptor serine/threonine kinases
TGF-βRI
Secondary FlyBase ID(s)
References (5)