FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term transmembrane receptor protein serine/threonine kinase activity ID (Ontology) GO:0004675 (Gene Ontology)
Definition Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 transmembrane receptor protein serine/threonine kinase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | transmembrane receptor protein serine/threonine kinase activity       --
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protein kinase activity
 |__protein serine/threonine kinase activity________
 |__transmembrane receptor protein kinase activity__|
transmembrane signaling receptor activity           |
 |__transmembrane receptor protein kinase activity__|
                                                    transmembrane receptor protein serine/threonine kinase activity  8 rec.
                                                     |__activin receptor activity 4 rec.
                                                     |   |__activin receptor activity, type I 2 rec.
                                                     |   |__activin receptor activity, type II 2 rec.
                                                     |__BMP receptor activity 4 rec.
                                                     |__transforming growth factor beta receptor activity 2 rec.
                                                         |__transforming growth factor beta receptor activity, type I 1 rec.
                                                         |__transforming growth factor beta receptor activity, type II
                                                         |__transforming growth factor beta receptor activity, type III
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Is a protein serine/threonine kinase activity
transmembrane receptor protein kinase activity
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Synonyms
  • "receptor protein serine/threonine kinase activity" RELATED[ EC:2 ]
    "receptor serine/threonine protein kinase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.7.11.30
MetaCyc:2.7.11.30-RXN
Reactome:R-HSA-170868 "Activated type I receptor phosphorylates SMAD2/3 directly"
Reactome:R-HSA-198732 "STAT3 activation"
Reactome:R-HSA-201476 "Activated type I receptor phosphorylates R-Smad1/5/8 directly"
RHEA:18673