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General Information
Symbol
Dmel\saxP
Species
D. melanogaster
Name
FlyBase ID
FBal0035538
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

A P{lacW} insertion after amino acid 34 of sax-PA.

A P{lacW} element is inserted after amino acid 34 of sax-PA, just 5' to the GAC codon encoding amino acid 35 of the sax-PA open reading frame, and upstream from the ATG encoding methionine amino acid 36. The sax-PB open reading frame is predicted to remain intact.

P element insert just downstream of the putative signal sequence, after amino acid 36, in the same orientation as the sax transcript.

Insertion components
P{lacW}saxP
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Germaria from one week old females are smaller than wild type and contain only one or two stem cells. Older females may have none, though though cysts and egg chambers remain.

Female adult escapers are less viable than their heterozygous siblings. Rare embryos from these females show a phenotype similar to but milder and more variable than those from sax1/sax2 females. Homozygous embryos are lacking the second midgut constriction. Homozygous females often lack the anterior crossvein, and the eyes are small due to reduced numbers of ommatidia.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

When saxP/+ females are crossed to dpphr4/+ males, most of the resulting dpphr4/+ progeny die.

When saxP/+ females are crossed to males with any one of the dpp[hr56]/+, dpp[hr90]/+ or dpp[e87]/+ genotypes, the resulting heterozygous dpp mutant progeny show poor viability.

saxP heterozygous mothers generate synthetic lethality when crossed to scwE1/+ males.

saxP heterozygous mothers generate synthetic lethality when crossed to scwE2/+ males.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Strong hypomorph.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)