FB2026_02 , released June 18, 2026
Allele: Dmel\scwE1
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General Information
Symbol
Dmel\scwE1
Species
D. melanogaster
Name
FlyBase ID
FBal0046423
Feature type
allele
Associated gene
Dmel\scw
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

gain of function allele

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Raftery et al., 1995)

gain of function allele

(Nicholls and Gelbart, 1998, Raftery et al., 1995)
Mutagen
ethyl methanesulfonate
(Raftery et al., 1995)
Progenitor genotype
Cytology
Description

Amino acid replacement: R91C.

(Künnapuu et al., 2014)

Nucleotide substitution: C271T.

(Künnapuu et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:19,700,652..19,700,652 [-]
Nucleotide change:

C19700652T

Reported nucleotide change:

C271T

Amino acid change:

R91C | scw-PA; R91C | scw-PB

Reported amino acid change:

R91C

(Künnapuu et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Transheterozygotes with scwE1R1 exhibit complete failure of head involution, internalised posterior structures and reduction in the amount of dorsal ectoderm.

      (Raftery et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      scwE1 is an enhancer of phenotype of dpphr4

      (Raftery et al., 1995)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      sax1 heterozygous mothers generate synthetic lethality when crossed to scwE1/+ males.

      sax2 heterozygous mothers generate synthetic lethality when crossed to scwE1/+ males.

      saxP heterozygous mothers generate synthetic lethality when crossed to scwE2/+ males.

      (Twombly et al., 2009)

      Phenotype strongly enhanced by Df(2R)Pcl11B and Df(3L)66C-G28. Enhancement acts with a maternal effect.

      (Nicholls and Gelbart, 1998)

      Zygotic lethal interaction with dpphr4 is due to a loss of dorsal-most fates in the embryos, the interaction engenders loss of amnioserosa as severe as the dpphr4 homozygous phenotype. The interaction with dpp can be reverted without losing homozygous lethality.

      (Raftery et al., 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Mutation is either antimorphic against dpp (if dpp and scw normally act in the same pathway) or neomorphic (if dpp and scw normally act in parallel pathways). Similar dorsal-ventral patterning defects suggest the genes act in the same pathway.

      (Raftery et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      scwE1
      (Künnapuu et al., 2014, Twombly et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)