FB2022_03, released June 9, 2022

Gene: Dmel\scw

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General Information
Symbol
Dmel\scw
Species
D. melanogaster
Name
screw
Annotation Symbol
CG31695
Feature Type
protein_coding_gene
FlyBase ID
FBgn0005590
Gene Model Status
Current
Stock Availability
18 publicly available
Gene Summary
screw (scw) encodes a BMP-type ligand that forms a heterodimer with the product of dpp. The heterodimer is required to achieve the peak levels of BMP signal in the dorsal-most cells of the early blastoderm embryo that are necessary to specify the amnioserosa. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(2)37Ff

Key Links
Genomic Location
Cytogenetic map
38A1-38A1
Sequence location
Recombination map
2-54
RefSeq locus
NT_033779 REGION:19699379..19700968
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables protein heterodimerization activity
inferred from physical interaction with UniProtKB:P07713
(assigned by UniProt )
(Shimmi et al., 2005)
inferred from physical interaction with FLYBASE:dpp; FB:FBgn0000490
(Künnapuu et al., 2014)
enables receptor ligand activity
inferred from direct assay
(Shimmi et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables cytokine activity
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
(Gaudet et al., 2011)
enables growth factor activity
inferred from electronic annotation with InterPro:IPR001111, InterPro:IPR001839, InterPro:IPR017948
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (8 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in amnioserosa formation
inferred from mutant phenotype
(Nguyen et al., 1998, Arora et al., 1994)
involved_in BMP signaling pathway
inferred from genetic interaction with FLYBASE:sax; FB:FBgn0003317, FLYBASE:tkv; FB:FBgn0003716
(Nguyen et al., 1998)
inferred from genetic interaction with FLYBASE:dpp; FB:FBgn0000490
(Raftery et al., 1995, Arora et al., 1994)
inferred from direct assay
(Künnapuu et al., 2014, Shimmi et al., 2005)
involved_in digestive tract mesoderm development
inferred from mutant phenotype
(Weyers et al., 2011)
involved_in dorsal/ventral pattern formation
inferred from mutant phenotype
(Arora et al., 1994)
involved_in gonad development
inferred from mutant phenotype
(Weyers et al., 2011)
involved_in imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Nguyen et al., 1998)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in BMP signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000932183
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in dorsal/ventral pattern formation
traceable author statement
(Raftery and Sutherland, 2003)
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in SMAD protein signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in extracellular space
inferred from direct assay
(Künnapuu et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in extracellular space
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in extracellular space
inferred from sequence or structural similarity with FLYBASE:dpp; FB:FBgn0000490
(Arora et al., 1994)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the TGF-beta family. (P54631)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
screw (scw) encodes a BMP-type ligand that forms a heterodimer with the product of dpp. The heterodimer is required to achieve the peak levels of BMP signal in the dorsal-most cells of the early blastoderm embryo that are necessary to specify the amnioserosa. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
BONE MORPHOGENETIC PROTEINS -
Bone Morphogenetic Proteins (BMPs) are a subfamily of the Transforming Growth Factor (TGF)-β family - a group of extracellular ligands for the TGF-β-Receptor family. The binding of a BMP dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
Pathway (FlyBase)
BMP Signaling Pathway Core Components -
The Bone Morphogenetic Protein (BMP) signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of a BMP family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
Protein Function (UniProtKB)
Part of the signal that specifies dorsal cell fates in the embryo. Acts together with dpp.
(UniProt, P54631)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
scw: screw
Embyonic lethal; partially ventralized; cephalic furrow shifted dorsally with defects in germ band extension. Ventral denticles extended laterally; spiracles and two to three terminal segments retracted into embryo (Arora and Nusslein-Volhard).
Summary (Interactive Fly)

TGF-ß superfamily - the Scw/dpp heterodimer is required to achieve the peak levels of BMP signal in the dorsal-most cells of the early blastoderm embryo that are necessary to specify the amnioserosa.

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\scw for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P54631)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
scw-RA
FBtr0081261
NM_080124
1342
400
scw-RB
FBtr0343860
NM_001299159
1590
400
Additional Transcript Data and Comments
Reported size (kB)

1.7, 1.4 (northern blot)

(Arora et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
scw-PA
FBpp0080802
45.9
400
8.21
P54631
NP_524863
AAN11056
scw-PB
FBpp0310402
45.9
400
8.21
P54631
NP_001286088
AHN54602
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

400 aa isoforms: scw-PA, scw-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

400 (aa); 44 (kD predicted)

(Arora et al., 1994)
Comments
External Data
Subunit Structure (UniProtKB)

Heterodimers of scw/dpp are the active subunit, dpp/dpp homodimers elicit a basal response and scw/scw homodimers alone are ineffective in specifying a dorsal pattern.

(UniProt, P54631)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\scw using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:
 low
high 
Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.
Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:
 low
high 
as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
central brain anlage in statu nascendi
(Fisher et al., 2012)
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
organism

Comment: rapidly degraded

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Arora et al., 1994)
embryonic stage 4
(Arora et al., 1994)
embryonic stage 5 -- 9

Comment: reference states 2-4 hr AEL

(Arora et al., 1994)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data

scw protein is secreted.

(Arora et al., 1994)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in extracellular space
inferred from direct assay
(Künnapuu et al., 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\scw in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 16 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 38 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of scw
Transgenic constructs containing regulatory region of scw
Aberrations (Deficiencies and Duplications) ( 27 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die during embryonic stage
lethal - all die during embryonic stage | recessive
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
Other Phenotypes
Allele
abnormal circadian rhythm, with Scer\GAL4P2.4.Pdf
abnormal circadian rhythm | heat sensitive, with Scer\GAL4tim.PE, Scer\GAL80Pdf.PS
some die during embryonic stage
some die during embryonic stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4A9
wild-type
Phenotype manifest in
Allele
abdomen
abdominal 1 ventral denticle belt
abdominal 2 ventral denticle belt
abdominal 3 ventral denticle belt
abdominal 4 ventral denticle belt
abdominal 5 ventral denticle belt
abdominal 6 ventral denticle belt
abdominal 7 ventral denticle belt
amnioserosa
cephalic furrow
cephalopharyngeal skeleton | embryonic stage
denticle belt
dorsal ectoderm (with scwE1)
dorsal ectoderm (with scwE1R1)
embryo | dorsal
embryo | embryonic stage 14 (with scwE1)
embryo | embryonic stage 14 (with scwE1R1)
embryo | posterior
embryonic/larval crystal cell
embryonic/larval dorsal vessel
embryonic/larval posterior spiracle
embryonic/larval spiracle
embryonic leading edge cell
filzkorper
filzkorper | embryonic stage
gonad | embryonic stage (with scw8.48)
gonad | embryonic stage (with scw62.25)
mitotic domain 1 | extended germ band stage
visceral mesoderm
visceral mesoderm | embryonic stage (with scw8.48)
visceral mesoderm | embryonic stage (with scw62.25)
wing, with Scer\GAL4A9
wing | distal, with Scer\GAL4A9
wing blade posterior compartment, with Scer\GAL4A9
wing vein, with Scer\GAL4A9
wing vein | ectopic, with Scer\GAL4A9
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (34)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\BMP5
8 of 15
Yes
No
Hsap\BMP6
7 of 15
No
No
Hsap\BMP7
7 of 15
No
No
5  
Hsap\BMP8A
7 of 15
No
No
Hsap\BMP8B
6 of 15
No
No
Hsap\BMP2
2 of 15
No
No
1  
Hsap\BMP3
2 of 15
No
Yes
1  
Hsap\BMP4
2 of 15
No
No
1  
Hsap\BMP10
2 of 15
No
Yes
Hsap\BMP15
2 of 15
No
Yes
Hsap\GDF1
2 of 15
No
No
Hsap\GDF2
2 of 15
No
Yes
Hsap\GDF3
2 of 15
No
No
Hsap\GDF5
2 of 15
No
Yes
Hsap\GDF6
2 of 15
No
Yes
Hsap\GDF7
2 of 15
No
Yes
Hsap\GDF9
2 of 15
No
Yes
Hsap\GDF10
2 of 15
No
Yes
Hsap\GDF15
2 of 15
No
No
Hsap\LEFTY1
2 of 15
No
Yes
Hsap\LEFTY2
2 of 15
No
Yes
Hsap\NODAL
2 of 15
No
No
Hsap\TGFB1
2 of 15
No
No
Hsap\TGFB2
2 of 15
No
No
1  
Hsap\TGFB3
2 of 15
No
No
1  
Hsap\AMH
1 of 15
No
Yes
Hsap\GDF11
1 of 15
No
No
1  
Hsap\IGFBP6
1 of 15
No
Yes
Hsap\INHA
1 of 15
No
No
Hsap\INHBA
1 of 15
No
No
2  
Hsap\INHBB
1 of 15
No
No
1  
Hsap\INHBC
1 of 15
No
No
1  
Hsap\INHBE
1 of 15
No
No
1  
Hsap\MSTN
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (33)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Bmp5
8 of 15
Yes
No
Mmus\Bmp6
7 of 15
No
No
Mmus\Bmp8a
7 of 15
No
No
Mmus\Bmp8b
7 of 15
No
No
Mmus\Bmp7
6 of 15
No
No
Mmus\Bmp2
2 of 15
No
No
Mmus\Bmp3
2 of 15
No
Yes
Mmus\Bmp4
2 of 15
No
No
Mmus\Bmp10
2 of 15
No
Yes
Mmus\Bmp15
2 of 15
No
Yes
Mmus\Gdf1
2 of 15
No
No
Mmus\Gdf2
2 of 15
No
Yes
Mmus\Gdf3
2 of 15
No
No
Mmus\Gdf5
2 of 15
No
Yes
Mmus\Gdf6
2 of 15
No
Yes
Mmus\Gdf7
2 of 15
No
Yes
Mmus\Gdf9
2 of 15
No
Yes
Mmus\Gdf10
2 of 15
No
Yes
Mmus\Gdf15
2 of 15
No
Yes
Mmus\Lefty1
2 of 15
No
Yes
Mmus\Lefty2
2 of 15
No
Yes
Mmus\Nodal
2 of 15
No
No
Mmus\Tgfb1
2 of 15
No
No
Mmus\Tgfb2
2 of 15
No
No
Mmus\Tgfb3
2 of 15
No
No
Mmus\Amh
1 of 15
No
Yes
Mmus\Gdf11
1 of 15
No
No
Mmus\Inha
1 of 15
No
No
Mmus\Inhba
1 of 15
No
No
Mmus\Inhbb
1 of 15
No
No
Mmus\Inhbc
1 of 15
No
No
Mmus\Inhbe
1 of 15
No
No
Mmus\Mstn
1 of 15
No
No
Rattus norvegicus (Norway rat) (33)
Rnor\Bmp6
7 of 13
Yes
No
Rnor\Bmp8b
7 of 13
Yes
No
Rnor\Bmp8a
6 of 13
No
No
Rnor\Bmp7
4 of 13
No
No
Rnor\Bmp5
3 of 13
No
Yes
Rnor\Bmp2
2 of 13
No
No
Rnor\Bmp3
2 of 13
No
Yes
Rnor\Bmp4
2 of 13
No
No
Rnor\Bmp10
2 of 13
No
Yes
Rnor\Bmp15
2 of 13
No
Yes
Rnor\Gdf1
2 of 13
No
No
Rnor\Gdf3
2 of 13
No
No
Rnor\Gdf5
2 of 13
No
Yes
Rnor\Gdf6
2 of 13
No
Yes
Rnor\Gdf7
2 of 13
No
Yes
Rnor\Gdf9
2 of 13
No
Yes
Rnor\Gdf15
2 of 13
No
No
Rnor\Lefty1
2 of 13
No
Yes
Rnor\Nodal
2 of 13
No
No
Rnor\Tgfb1
2 of 13
No
No
Rnor\Tgfb2
2 of 13
No
No
Rnor\Tgfb3
2 of 13
No
Yes
Rnor\Amh
1 of 13
No
Yes
Rnor\Cers1
1 of 13
No
Yes
Rnor\Gdf2
1 of 13
No
Yes
Rnor\Gdf10
1 of 13
No
Yes
Rnor\Gdf11
1 of 13
No
No
Rnor\Inha
1 of 13
No
No
Rnor\Inhba
1 of 13
No
No
Rnor\Inhbc
1 of 13
No
No
Rnor\Inhbe
1 of 13
No
No
Rnor\Lefty2
1 of 13
No
Yes
Rnor\Mstn
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (33)
Xtro\bmp6
6 of 12
Yes
No
Xtro\bmp7.2
6 of 12
Yes
No
Xtro\bmp8
6 of 12
Yes
No
Xtro\bmp5
5 of 12
No
No
Xtro\bmp7.1
5 of 12
No
No
Xtro\bmp2
2 of 12
No
No
Xtro\bmp3
2 of 12
No
Yes
Xtro\bmp4
2 of 12
No
No
Xtro\bmp10
2 of 12
No
Yes
Xtro\bmp15
2 of 12
No
Yes
Xtro\gdf1
2 of 12
No
No
Xtro\gdf2
2 of 12
No
Yes
Xtro\gdf3
2 of 12
No
No
Xtro\gdf5
2 of 12
No
Yes
Xtro\gdf7
2 of 12
No
No
Xtro\gdf9
2 of 12
No
Yes
Xtro\gdf10
2 of 12
No
Yes
Xtro\nodal1
2 of 12
No
No
Xtro\nodal5
2 of 12
No
No
Xtro\nodal6
2 of 12
No
No
Xtro\nodal
2 of 12
No
No
Xtro\tgfb1
2 of 12
No
No
Xtro\tgfb2
2 of 12
No
No
Xtro\admp2
1 of 12
No
Yes
Xtro\admp
1 of 12
No
Yes
Xtro\gdf11.1
1 of 12
No
No
Xtro\inha
1 of 12
No
No
Xtro\inhbc.1
1 of 12
No
No
Xtro\lefty
1 of 12
No
Yes
Xtro\LOC101732995
1 of 12
No
Yes
Xtro\mstn.1
1 of 12
No
No
Xtro\nodal3.2
1 of 12
No
Yes
Xtro\nodal
1 of 12
No
No
Danio rerio (Zebrafish) (43)
Drer\bmp7a
7 of 15
Yes
No
Drer\bmp7b
7 of 15
Yes
No
Drer\bmp8a
7 of 15
Yes
No
Drer\bmp6
6 of 15
No
No
Drer\bmp5
4 of 15
No
No
Drer\ndr2
3 of 15
No
Yes
Drer\bmp2a
2 of 15
No
No
Drer\bmp2b
2 of 15
No
No
Drer\bmp3
2 of 15
No
Yes
Drer\bmp4
2 of 15
No
No
Drer\bmp10
2 of 15
No
Yes
Drer\bmp10l
2 of 15
No
Yes
Drer\gdf2
2 of 15
No
Yes
Drer\gdf3
2 of 15
No
No
Drer\gdf5
2 of 15
No
Yes
Drer\gdf6a
2 of 15
No
Yes
Drer\gdf6b
2 of 15
No
No
Drer\gdf7
2 of 15
No
No
Drer\gdf9
2 of 15
No
Yes
Drer\gdf10a
2 of 15
No
Yes
Drer\gdf10b
2 of 15
No
Yes
Drer\lft1
2 of 15
No
Yes
Drer\lft2
2 of 15
No
Yes
Drer\ndr1
2 of 15
No
Yes
Drer\spaw
2 of 15
No
Yes
Drer\tgfb1a
2 of 15
No
No
Drer\tgfb1b
2 of 15
No
No
Drer\tgfb2
2 of 15
No
No
Drer\tgfb3
2 of 15
No
Yes
Drer\tgfb5
2 of 15
No
No
Drer\admp
1 of 15
No
Yes
Drer\amh
1 of 15
No
Yes
Drer\bmp15
1 of 15
No
Yes
Drer\bmp16
1 of 15
No
No
Drer\gdf11
1 of 15
No
No
Drer\inha
1 of 15
No
No
Drer\inhbaa
1 of 15
No
No
Drer\inhbab
1 of 15
No
No
Drer\inhbb
1 of 15
No
No
Drer\LOC100329520
1 of 15
No
No
Drer\LOC101885590
1 of 15
No
Yes
Drer\mstna
1 of 15
No
No
Drer\mstnb
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\tig-2
7 of 15
Yes
Yes
Cele\dbl-1
3 of 15
No
No
Cele\daf-7
2 of 15
No
No
Cele\tig-3
2 of 15
No
No
Cele\unc-129
2 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
gbb
5 of 10
dpp
4 of 10
daw
3 of 10
mav
3 of 10
myo
3 of 10
Actβ
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    BMP5; bone morphogenetic protein 5
    8 of 15
    112265
        BMP6; bone morphogenetic protein 6
        7 of 15
        112266
            BMP7; bone morphogenetic protein 7
            7 of 15
            112267
                 
                BMP8A; bone morphogenetic protein 8a
                7 of 15
                    BMP8B; bone morphogenetic protein 8b
                    6 of 15
                    602284
                        Functional Complementation Data
                        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                        Interactions
                        Summary of Physical Interactions
                        Summary of Genetic Interactions
                        esyN Network Diagram
                        esyN Network Key:
                        Suppression
                        Enhancement
                        View in Interactions Browser
                        Please look at the allele data for full details of the genetic interactions
                        Starting gene(s)
                        Interaction type
                        Interacting gene(s)
                        Reference
                        scw
                        suppressible
                        sax
                        (Nguyen et al., 1998)
                        scw
                        suppressible
                        sog
                        (Nguyen et al., 1998)
                        scw
                        suppressible
                        tkv
                        (Nguyen et al., 1998)
                        Starting gene(s)
                        Interaction type
                        Interacting gene(s)
                        Reference
                        dpp
                        enhanceable
                        scw
                        (Raftery et al., 1995)
                        gbb
                        suppressible
                        scw
                        (Tauscher et al., 2016, Fritsch et al., 2010)
                        External Data
                        Subunit Structure (UniProtKB)
                        Heterodimers of scw/dpp are the active subunit, dpp/dpp homodimers elicit a basal response and scw/scw homodimers alone are ineffective in specifying a dorsal pattern.
                        (UniProt, P54631 )
                        Linkouts
                        BioGRID - A database of protein and genetic interactions.
                        DroID - A comprehensive database of gene and protein interactions.
                        MIST (genetic) - An integrated Molecular Interaction Database
                        MIST (protein-protein) - An integrated Molecular Interaction Database
                        Pathways
                        Signaling Pathways (FlyBase)
                        BMP Signaling Pathway Core Components -
                        The Bone Morphogenetic Protein (BMP) signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of a BMP family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
                        Metabolic Pathways
                        External Data
                        Linkouts
                        Genomic Location and Detailed Mapping Data
                        Chromosome (arm)
                        2L
                        Recombination map
                        2-54
                        Cytogenetic map
                        38A1-38A1
                        Sequence location
                        FlyBase Computed Cytological Location
                        Cytogenetic map
                        Evidence for location
                        38A1-38A1
                        Limits computationally determined from genome sequence between P{EP}EP623&P{PZ}spi01068 and P{lacW}l(2)k10239k10239
                        Experimentally Determined Cytological Location
                        Cytogenetic map
                        Notes
                        References
                        Experimentally Determined Recombination Data
                        Location

                        2-54

                        (FlyBase, 2016)

                        2-53.7

                        (Comeron et al., 2012)

                        2-53

                        (Tearle and Nusslein-Volhard, 1987)
                        Left of (cM)
                        Right of (cM)
                        Notes

                        scwE1 and scwE2 are located 0.08cM apart.

                        (Raftery et al., 1995)
                        Stocks and Reagents
                        Stocks (18)
                        Genomic Clones (15)
                         

                        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                        cDNA Clones (5)
                         

                        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                        cDNA clones, fully sequenced
                        BDGP DGC clones
                        Other clones
                        Drosophila Genomics Resource Center cDNA clones

                        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                        cDNA Clones, End Sequenced (ESTs)
                        BDGP DGC clones
                        Other clones
                          RNAi and Array Information
                          Linkouts
                          DRSC - Results frm RNAi screens
                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                          Antibody Information
                          Laboratory Generated Antibodies
                           
                          Commercially Available Antibodies
                           
                          Other Information
                          Relationship to Other Genes
                          Source for database identify of
                          Source for database merge of

                          Source for merge of: scw BcDNA:LD30945

                          (FlyBase, 1996-)
                          Additional comments

                          Source for merge of scw BcDNA:LD30945 was a shared cDNA ( date:030728 ).

                          (FlyBase, 1996-)
                          Other Comments

                          The scw product negatively regulates dac expression in the embryonic head.

                          (Anderson et al., 2006)

                          New annotation (CG31695) in release 3 of the genome annotation.

                          (FlyBase Genome Annotators, 2002-2003)

                          dpp/tkv signaling is obligatorily required, while scw/sax signaling is necessary but not sufficient for dorsal patterning in the embryo.

                          (Nguyen et al., 1998)

                          scw is located between exons 4 and 5 of Lar.

                          (Krueger et al., 1996)

                          scw positively modulates dpp activity.

                          (Arora et al., 1995)

                          Genetic and phenotypic data reveals that scw is involved in post-transcriptional regulation of dpp activity by elevating dpp activity dorsally. Mutations in scw disrupt amnioserosa formation. Injection of dpp RNA into the ventral side does not result in an asymmetric response, a second amnioserosa forms at the site of injection. This suggests that the scw protein is critical to the local response to dpp RNA.

                          (Neul and Ferguson, 1995)

                          scw and dpp act together to establish distinct response boundaries within the dorsal half of the embryo, perhaps by forming heterodimers that have a higher activity than homodimers of either molecule alone.

                          (Arora et al., 1994)

                          scw alleles display relative phenotypic strengths, this may be correlated to the progressive loss of dorsal pattern elements in the ventralised mutants.

                          (Arora and Nusslein-Volhard, 1992)

                          scw has been molecularly characterised.

                          (Arora et al., 1992)

                          scw is required for the normal ontogeny of the zen pattern and fating of the amnioserosa.

                          (Ray et al., 1991)

                          Involved in the regulatory hierarchy responsible for the asymmetric distribution and function of zygotic regulatory gene products along the DV axis of early embryos. scw mutants exhibit a weak ventralising phenotype in which the maintenance of the zen pattern is affected.

                          (Rushlow and Levine, 1990)
                          Origin and Etymology
                          Discoverer
                          Etymology
                          Identification
                          External Crossreferences and Linkouts ( 44 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                          Other crossreferences
                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                          Flygut - An atlas of the Drosophila adult midgut
                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                          InterPro - A database of protein families, domains and functional sites
                          KEGG Genes - Molecular building blocks of life in the genomic space.
                          MARRVEL_MODEL - MARRVEL (model organism gene)
                          modMine - A data warehouse for the modENCODE project
                          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                          Linkouts
                          BioGRID - A database of protein and genetic interactions.
                          DroID - A comprehensive database of gene and protein interactions.
                          DRSC - Results frm RNAi screens
                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                          FlyMine - An integrated database for Drosophila genomics
                          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                          MIST (genetic) - An integrated Molecular Interaction Database
                          MIST (protein-protein) - An integrated Molecular Interaction Database
                          Synonyms and Secondary IDs (12)
                          Reported As
                          Symbol Synonym
                          BcDNA:LD30945
                          CG31695
                          (Hosono et al., 2015, Keleman et al., 2009.8.5, Brandt, 2006)
                          DmSCW
                          (Wisotzkey and Newfeld, 2020)
                          SCW
                          (Bickel et al., 2008)
                          Scw
                          (Madamanchi et al., 2021, Negreiros et al., 2018, Upadhyay et al., 2017, Matsuda et al., 2016, Tauscher et al., 2016, Bier and De Robertis, 2015, Ting et al., 2014, Mbodj et al., 2013, Sawala et al., 2012, Peluso et al., 2011, Wang et al., 2008, Pistillo and Desplan, 2007, Dudu, 2006, Umulis et al., 2006, Wang and Ferguson, 2004)
                          l(2)37Ff
                          (Jones and McGinnis, 1993)
                          l(2)IG76
                          mor2
                          (Weyers et al., 2011)
                          screw
                          (Gautam et al., 2021)
                          scw
                          (Kubrak et al., 2022, Rushton et al., 2020, Statzer and Ewald, 2020, Jia et al., 2018, Transgenic RNAi Project members, 2017-, Sandler and Stathopoulos, 2016, Tauscher et al., 2016, Ray, 2015.6.29, Ray, 2015.6.29, Deshpande et al., 2014, Künnapuu et al., 2014, Beckwith et al., 2013, Chen et al., 2013, Saunders et al., 2013, Wotton et al., 2013, Fritsch et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Fritsch et al., 2010, Salzer et al., 2010, Umulis et al., 2010, Pentek et al., 2009, Twombly et al., 2009, Liang et al., 2008, Fritsch and Ray, 2007, Junion et al., 2007, Lecuyer et al., 2007, Anderson et al., 2006, Brandt, 2006, Gim et al., 2001)
                          Name Synonyms
                          Screw
                          (Destalminil-Letourneau et al., 2021, Shimmi and Newfeld, 2013, Umulis et al., 2010, Bickel et al., 2008, Wang et al., 2008, Fritsch and Ray, 2007, Stathopoulos and Levine, 2005, Gim et al., 2001)
                          morphological defects 2
                          (Weyers et al., 2011)
                          screw
                          (Wieschaus and Nüsslein-Volhard, 2016, Heimiller et al., 2014, Künnapuu et al., 2014, Wotton et al., 2013, Weyers et al., 2011, Salzer et al., 2010, Wright et al., 2010, Twombly et al., 2009, Anderson et al., 2006, Arora, 1994.11.23)
                          Secondary FlyBase IDs
                          • FBgn0002053
                          • FBgn0003343
                          • FBgn0046219
                          • FBgn0051695
                          Datasets (0)
                          Study focus (0)
                          Experimental Role
                          Project
                          Project Type
                          Title
                          Study result (0)
                          Result
                          Result Type
                          Title
                          References (198)