l(2)37Ff
TGF-ß superfamily - the Scw/dpp heterodimer is required to achieve the peak levels of BMP signal in the dorsal-most cells of the early blastoderm embryo that are necessary to specify the amnioserosa.
Please see the JBrowse view of Dmel\scw for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.44
Gene model reviewed during 5.52
1.7, 1.4 (northern blot)
400 (aa); 44 (kD predicted)
Heterodimers of scw/dpp are the active subunit, dpp/dpp homodimers elicit a basal response and scw/scw homodimers alone are ineffective in specifying a dorsal pattern.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\scw using the Feature Mapper tool.
Comment: anlage in statu nascendi
Comment: rapidly degraded
Comment: anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reference states 2-4 hr AEL
scw protein is secreted.
GBrowse - Visual display of RNA-Seq signals
View Dmel\scw in GBrowse 2Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: scw BcDNA:LD30945
Source for merge of scw BcDNA:LD30945 was a shared cDNA ( date:030728 ).
New annotation (CG31695) in release 3 of the genome annotation.
Genetic and phenotypic data reveals that scw is involved in post-transcriptional regulation of dpp activity by elevating dpp activity dorsally. Mutations in scw disrupt amnioserosa formation. Injection of dpp RNA into the ventral side does not result in an asymmetric response, a second amnioserosa forms at the site of injection. This suggests that the scw protein is critical to the local response to dpp RNA.
scw alleles display relative phenotypic strengths, this may be correlated to the progressive loss of dorsal pattern elements in the ventralised mutants.
scw has been molecularly characterised.
scw is required for the normal ontogeny of the zen pattern and fating of the amnioserosa.