FlyBase Gene Report: Dmel\scw

General Information

Symbol

Dmel\scw

Species

D. melanogaster

Name

screw

Annotation Symbol

CG31695

Feature Type

protein_coding_gene

FlyBase ID

FBgn0005590

Gene Model Status

Current

Stock Availability

18 publicly available

Gene Summary

screw (scw) encodes a BMP-type ligand that forms a heterodimer with the product of dpp. The heterodimer is required to achieve the peak levels of BMP signal in the dorsal-most cells of the early blastoderm embryo that are necessary to specify the amnioserosa. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

l(2)37Ff

Key Links

Genomic Location

Cytogenetic map

38A1-38A1

Sequence location

2L:19,699,379..19,700,968 [-]

Recombination map

2-54

RefSeq locus

NT_033779 REGION:19699379..19700968

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables protein heterodimerization activity

inferred from physical interaction with UniProtKB:P07713

(assigned by UniProt )

(Shimmi et al., 2005)

inferred from physical interaction with FLYBASE:dpp; FB:FBgn0000490

(Künnapuu et al., 2014)

enables receptor ligand activity

inferred from direct assay

(Shimmi et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables cytokine activity

inferred from biological aspect of ancestor with PANTHER:PTN000218063

(assigned by GO_Central )

(Gaudet et al., 2011)

enables growth factor activity

inferred from electronic annotation with InterPro:IPR001111, InterPro:IPR001839, InterPro:IPR017948

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in amnioserosa formation

inferred from mutant phenotype

(Nguyen et al., 1998, Arora et al., 1994)

involved_in BMP signaling pathway

inferred from genetic interaction with FLYBASE:sax; FB:FBgn0003317, FLYBASE:tkv; FB:FBgn0003716

(Nguyen et al., 1998)

inferred from genetic interaction with FLYBASE:dpp; FB:FBgn0000490

(Raftery et al., 1995, Arora et al., 1994)

inferred from direct assay

(Künnapuu et al., 2014, Shimmi et al., 2005)

involved_in digestive tract mesoderm development

inferred from mutant phenotype

(Weyers et al., 2011)

involved_in dorsal/ventral pattern formation

inferred from mutant phenotype

(Arora et al., 1994)

involved_in gonad development

inferred from mutant phenotype

(Weyers et al., 2011)

involved_in imaginal disc-derived wing morphogenesis

inferred from mutant phenotype

(Nguyen et al., 1998)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in BMP signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000932183

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in dorsal/ventral pattern formation

traceable author statement

(Raftery and Sutherland, 2003)

involved_in positive regulation of pathway-restricted SMAD protein phosphorylation

inferred from biological aspect of ancestor with PANTHER:PTN000218063

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in SMAD protein signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000218063

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Künnapuu et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN000218063

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in extracellular space

inferred from sequence or structural similarity with FLYBASE:dpp; FB:FBgn0000490

(Arora et al., 1994)

Gene Group (FlyBase)

BONE MORPHOGENETIC PROTEINS

Pathway (FlyBase)

BMP Signaling Pathway Core Components

Protein Family (UniProt)

Belongs to the TGF-beta family. (P54631)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

BONE MORPHOGENETIC PROTEINS -: Bone Morphogenetic Proteins (BMPs) are a subfamily of the Transforming Growth Factor (TGF)-β family - a group of extracellular ligands for the TGF-β-Receptor family. The binding of a BMP dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)

Pathway (FlyBase)

BMP Signaling Pathway Core Components -: The Bone Morphogenetic Protein (BMP) signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of a BMP family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)

Protein Function (UniProtKB)

Part of the signal that specifies dorsal cell fates in the embryo. Acts together with dpp.

(UniProt, P54631)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

scw: screw

Embyonic lethal; partially ventralized; cephalic furrow shifted dorsally with defects in germ band extension. Ventral denticles extended laterally; spiracles and two to three terminal segments retracted into embryo (Arora and Nusslein-Volhard).

Summary (Interactive Fly)

TGF-ß superfamily - the Scw/dpp heterodimer is required to achieve the peak levels of BMP signal in the dorsal-most cells of the early blastoderm embryo that are necessary to specify the amnioserosa.

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\scw for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

scw-RA

FBtr0081261

NM_080124

1342

400

scw-RB

FBtr0343860

NM_001299159

1590

400

Additional Transcript Data and Comments

Reported size (kB)

1.7, 1.4 (northern blot)

(Arora et al., 1994)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

scw-PA

FBpp0080802

45.9

400

8.21

NP_524863

AAN11056

scw-PB

FBpp0310402

45.9

400

8.21

NP_001286088

AHN54602

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

400 aa isoforms: scw-PA, scw-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

400 (aa); 44 (kD predicted)

(Arora et al., 1994)

Comments

External Data

Subunit Structure (UniProtKB)

Heterodimers of scw/dpp are the active subunit, dpp/dpp homodimers elicit a basal response and scw/scw homodimers alone are ineffective in specifying a dorsal pattern.

(UniProt, P54631)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\scw using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

scw_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

central brain anlage in statu nascendi

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

organism

Comment: rapidly degraded

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Arora et al., 1994)

embryonic stage 4

(Arora et al., 1994)

embryonic stage 5 -- 9

Comment: reference states 2-4 hr AEL

(Arora et al., 1994)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

scw protein is secreted.

(Arora et al., 1994)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Künnapuu et al., 2014)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\scw in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\scw

View exonic expression by tissue for Dmel\scw

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0005590

DRscDB

46000/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0005590

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG31695-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31695

Flygut - An atlas of the Drosophila adult midgut

FBgn0005590

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\scw

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 16 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 38 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of scw

Transgenic constructs containing regulatory region of scw

Aberrations (Deficiencies and Duplications) ( 27 )

Inferred from experimentation ( 27 )

Gene not disrupted in

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during embryonic stage

lethal - all die during embryonic stage | recessive

partially lethal - majority die, with Scer\GAL4^pnr-MD237

scw^GD10334

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

scw^GD10334

viable, with Scer\GAL4^Mef2.PR

scw^GD10334

Other Phenotypes

Allele

abnormal circadian rhythm, with Scer\GAL4^P2.4.Pdf

scw^KK109520

abnormal circadian rhythm | heat sensitive, with Scer\GAL4^tim.PE, Scer\GAL80^Pdf.PS

scw^KK109520

some die during embryonic stage

some die during embryonic stage | recessive

some die during pupal stage, with Scer\GAL4^pnr-MD237

scw^GD10334

visible, with Scer\GAL4^A9

scw^UAS.cNa

wild-type

Phenotype manifest in

Allele

abdomen

scw²

abdominal 1 ventral denticle belt

scw⁵

abdominal 2 ventral denticle belt

scw⁵

abdominal 3 ventral denticle belt

scw⁵

abdominal 4 ventral denticle belt

scw⁵

abdominal 5 ventral denticle belt

scw⁵

abdominal 6 ventral denticle belt

scw⁵

abdominal 7 ventral denticle belt

scw⁵

amnioserosa

cephalic furrow

scw^unspecified

cephalopharyngeal skeleton | embryonic stage

scw²

denticle belt

scw^unspecified

dorsal ectoderm (with scw^E1)

scw^E1R1

dorsal ectoderm (with scw^E1R1)

scw^E1

embryo | dorsal

scw^unspecified

embryo | embryonic stage 14 (with scw^E1)

scw^E1R1

embryo | embryonic stage 14 (with scw^E1R1)

scw^E1

embryo | posterior

scw^unspecified

embryonic/larval crystal cell

scw^l1

embryonic/larval dorsal vessel

scw⁵

embryonic/larval posterior spiracle

scw^E2

embryonic/larval spiracle

scw^unspecified

embryonic leading edge cell

scw^l1

filzkorper

scw²

filzkorper | embryonic stage

scw⁵

gonad | embryonic stage (with scw^8.48)

scw^62.25

gonad | embryonic stage (with scw^62.25)

scw^8.48

mitotic domain 1 | extended germ band stage

visceral mesoderm

scw⁵

visceral mesoderm | embryonic stage (with scw^8.48)

scw^62.25

visceral mesoderm | embryonic stage (with scw^62.25)

scw^8.48

wing, with Scer\GAL4^A9

scw^UAS.cNa

wing | distal, with Scer\GAL4^A9

scw^UAS.cNa

wing blade posterior compartment, with Scer\GAL4^A9

scw^UAS.cNa

wing vein, with Scer\GAL4^A9

scw^UAS.cNa

wing vein | ectopic, with Scer\GAL4^A9

scw^UAS.cNa

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (34)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\BMP5

8 of 15

Yes

7 of 15

7 of 15

7 of 15

6 of 15

2 of 15

2 of 15

Yes

Hsap\BMP4

2 of 15

Hsap\BMP10

2 of 15

Yes

Hsap\BMP15

2 of 15

Yes

Hsap\GDF1

2 of 15

Hsap\GDF2

2 of 15

Yes

Hsap\GDF3

2 of 15

Hsap\GDF5

2 of 15

Yes

Hsap\GDF6

2 of 15

Yes

Hsap\GDF7

2 of 15

Yes

Hsap\GDF9

2 of 15

Yes

Hsap\GDF10

2 of 15

Yes

Hsap\GDF15

2 of 15

Hsap\LEFTY1

2 of 15

Yes

Hsap\LEFTY2

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Yes

Hsap\GDF11

1 of 15

Hsap\IGFBP6

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (33)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Bmp5

8 of 15

Yes

7 of 15

7 of 15

7 of 15

6 of 15

2 of 15

2 of 15

Yes

Mmus\Bmp4

2 of 15

Mmus\Bmp10

2 of 15

Yes

Mmus\Bmp15

2 of 15

Yes

Mmus\Gdf1

2 of 15

Mmus\Gdf2

2 of 15

Yes

Mmus\Gdf3

2 of 15

Mmus\Gdf5

2 of 15

Yes

Mmus\Gdf6

2 of 15

Yes

Mmus\Gdf7

2 of 15

Yes

Mmus\Gdf9

2 of 15

Yes

Mmus\Gdf10

2 of 15

Yes

Mmus\Gdf15

2 of 15

Yes

Mmus\Lefty1

2 of 15

Yes

Mmus\Lefty2

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (33)

Rnor\Bmp6

7 of 13

Yes

Rnor\Bmp8b

7 of 13

Yes

Rnor\Bmp8a

6 of 13

Rnor\Bmp7

4 of 13

Rnor\Bmp5

3 of 13

Yes

Rnor\Bmp2

2 of 13

Rnor\Bmp3

2 of 13

Yes

Rnor\Bmp4

2 of 13

Rnor\Bmp10

2 of 13

Yes

Rnor\Bmp15

2 of 13

Yes

Rnor\Gdf1

2 of 13

Rnor\Gdf3

2 of 13

Rnor\Gdf5

2 of 13

Yes

Rnor\Gdf6

2 of 13

Yes

Rnor\Gdf7

2 of 13

Yes

Rnor\Gdf9

2 of 13

Yes

Rnor\Gdf15

2 of 13

Rnor\Lefty1

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Rnor\Amh

1 of 13

Yes

Rnor\Cers1

1 of 13

Yes

Rnor\Gdf2

1 of 13

Yes

Rnor\Gdf10

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Mstn

1 of 13

Xenopus tropicalis (Western clawed frog) (33)

Xtro\bmp6

6 of 12

Yes

Xtro\bmp7.2

6 of 12

Yes

Xtro\bmp8

6 of 12

Yes

5 of 12

5 of 12

2 of 12

2 of 12

Yes

Xtro\bmp4

2 of 12

Xtro\bmp10

2 of 12

Yes

Xtro\bmp15

2 of 12

Yes

Xtro\gdf1

2 of 12

Xtro\gdf2

2 of 12

Yes

Xtro\gdf3

2 of 12

Xtro\gdf5

2 of 12

Yes

Xtro\gdf7

2 of 12

Xtro\gdf9

2 of 12

Yes

Xtro\gdf10

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

Yes

Xtro\admp

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\LOC101732995

1 of 12

Yes

Xtro\mstn.1

1 of 12

Xtro\nodal3.2

1 of 12

Yes

Xtro\nodal

1 of 12

Danio rerio (Zebrafish) (43)

Drer\bmp7a

7 of 15

Yes

Drer\bmp7b

7 of 15

Yes

Drer\bmp8a

7 of 15

Yes

Drer\bmp6

6 of 15

Drer\bmp5

4 of 15

Drer\ndr2

3 of 15

Yes

Drer\bmp2a

2 of 15

Drer\bmp2b

2 of 15

Drer\bmp3

2 of 15

Yes

Drer\bmp4

2 of 15

Drer\bmp10

2 of 15

Yes

Drer\bmp10l

2 of 15

Yes

Drer\gdf2

2 of 15

Yes

Drer\gdf3

2 of 15

Drer\gdf5

2 of 15

Yes

Drer\gdf6a

2 of 15

Yes

Drer\gdf6b

2 of 15

Drer\gdf7

2 of 15

Drer\gdf9

2 of 15

Yes

Drer\gdf10a

2 of 15

Yes

Drer\gdf10b

2 of 15

Yes

Drer\lft1

2 of 15

Yes

Drer\lft2

2 of 15

Yes

Drer\ndr1

2 of 15

Yes

Drer\spaw

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Drer\tgfb5

2 of 15

Drer\admp

1 of 15

Yes

Drer\amh

1 of 15

Yes

Drer\bmp15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\mstna

1 of 15

Drer\mstnb

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\tig-2

7 of 15

Yes

3 of 15

2 of 15

2 of 15

2 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919091A )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA16402

Drosophila persimilis

Dper\GL25533

Drosophila willistoni

Dwil\GK19051

Drosophila virilis

Dvir\GJ14689

Drosophila mojavensis

Dmoj\GI18196

Drosophila grimshawi

Dgri\scw

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150565 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17022791

Glossina morsitans

Tsetse fly

Gmor\GMOY008487

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_13438

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05E5 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA005940

Danaus plexippus

Monarch butterfly

Dple\DPOGS214213-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL006799

Apis florea

Little honeybee

Aflo\3099635092

Apis florea

Little honeybee

Aflo\2147491745

Apis mellifera

Western honey bee

Amel\gbb

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP25656

Bombus terrestris

Buff-tailed bumblebee

Bter\15207758

Linepithema humile

Argentine ant

Lhum\LH19457

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00211f

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0020e6

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003214

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_07218

Tribolium castaneum

Red flour beetle

Tcas\gbb1

Tribolium castaneum

Red flour beetle

Tcas\gbb2

Pediculus humanus

Human body louse

Phum\PHUM150910

Rhodnius prolixus

Kissing bug

Rpro\gbb

Cimex lectularius

Bed bug

Clec\CLEC013332

Cimex lectularius

Bed bug

Clec\CLEC012975

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000749

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_01036

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07ST )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR008167

Ixodes scapularis

Black-legged tick

Isca\ISCW019587

Stegodyphus mimosarum

African social velvet spider

Smim\KFM76088.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur17g02120

Tetranychus urticae

Two-spotted spider mite

Turt\tetur17g02870

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_347233

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0C2J )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ciona intestinalis

Vase tunicate

Cint\bmp5/7-like

Gallus gallus

Domestic chicken

Ggal\BMP7

Gallus gallus

Domestic chicken

Ggal\BMP6

Gallus gallus

Domestic chicken

Ggal\BMP5

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (6)

Gene Symbol

Score

Source

Alignment

gbb

5 of 10

dpp

4 of 10

daw

3 of 10

mav

3 of 10

myo

3 of 10

Actβ

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

BMP5; bone morphogenetic protein 5

8 of 15

112265

BMP6; bone morphogenetic protein 6

7 of 15

112266

BMP7; bone morphogenetic protein 7

7 of 15

112267

BMP8A; bone morphogenetic protein 8a

7 of 15

BMP8B; bone morphogenetic protein 8b

6 of 15

602284

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

scw

anti tag coimmunoprecipitation, anti tag western blot

(Künnapuu et al., 2014)

scw - dpp

anti tag coimmunoprecipitation, anti tag western blot, comigration in non denaturing gel electrophoresis, western blot

(Tauscher et al., 2016, Künnapuu et al., 2014, Shimmi et al., 2005)

scw - sog

coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation

(Negreiros et al., 2018, Shimmi et al., 2005)

scw - tsg

anti tag coimmunoprecipitation, anti tag western blot

(Shimmi et al., 2005)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

scw

suppressible

sax

(Nguyen et al., 1998)

scw

suppressible

sog

(Nguyen et al., 1998)

scw

suppressible

tkv

(Nguyen et al., 1998)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

dpp

enhanceable

scw

(Raftery et al., 1995)

gbb

suppressible

scw

(Tauscher et al., 2016, Fritsch et al., 2010)

External Data

Subunit Structure (UniProtKB)

Heterodimers of scw/dpp are the active subunit, dpp/dpp homodimers elicit a basal response and scw/scw homodimers alone are ineffective in specifying a dorsal pattern.

(UniProt, P54631 )

Linkouts

BioGRID - A database of protein and genetic interactions.

70052

DroID - A comprehensive database of gene and protein interactions.

FBgn0005590

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

BMP Signaling Pathway Core Components -: The Bone Morphogenetic Protein (BMP) signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of a BMP family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-54

Cytogenetic map

38A1-38A1

Sequence location

2L:19,699,379..19,700,968 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

38A1-38A1

Limits computationally determined from genome sequence between P{EP}EP623&P{PZ}spi⁰¹⁰⁶⁸ and P{lacW}l(2)k10239^k10239

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-54

(FlyBase, 2016)

2-53.7

(Comeron et al., 2012)

2-53

(Tearle and Nusslein-Volhard, 1987)

Left of (cM)

Right of (cM)

Notes

scw^E1 and scw^E2 are located 0.08cM apart.

(Raftery et al., 1995)

Stocks and Reagents

Stocks (18)

Bloomington

64098

y¹ w^*; P{scw-YFP.R}24.1

63061

y¹ w^*; P{UAS-scw.R}1/CyO

63062

P{scw-YFP.R}23.1, y¹ w^*/FM7h

4351

scw^l1 rdo¹ hook¹ pr¹/CyO

63060

y¹ w^*; P{UAS-scw.R}51/TM3, Sb¹ Ser¹

67535

y¹ sc^* v¹ sev²¹; P{TOE.GS00080}attP40

78331

dpy^ov1 scw^E2 cn¹ bw¹/CyO, P{dpp-P23}RP1

7306

w¹¹¹⁸; b¹ scw⁵ pr¹/CyO, P{sevRas1.V12}FK1

81324

y¹ sc^* v¹ sev²¹; P{SAM.dCas9.GS03177}attP40

Kyoto

107700

scw^l1 rdo¹ hook¹ pr¹/CyO

VDRC

v105303

P{KK109520}VIE-260B

v21400

w¹¹¹⁸; P{GD10334}v21400

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (5)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD30945

Other clones

DPiM_LD30945

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0005590

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0005590

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

46000

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: scw BcDNA:LD30945

(FlyBase, 1996-)

Additional comments

Source for merge of scw BcDNA:LD30945 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Other Comments

The scw product negatively regulates dac expression in the embryonic head.

(Anderson et al., 2006)

New annotation (CG31695) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

dpp/tkv signaling is obligatorily required, while scw/sax signaling is necessary but not sufficient for dorsal patterning in the embryo.

(Nguyen et al., 1998)

scw is located between exons 4 and 5 of Lar.

(Krueger et al., 1996)

scw positively modulates dpp activity.

(Arora et al., 1995)

Genetic and phenotypic data reveals that scw is involved in post-transcriptional regulation of dpp activity by elevating dpp activity dorsally. Mutations in scw disrupt amnioserosa formation. Injection of dpp RNA into the ventral side does not result in an asymmetric response, a second amnioserosa forms at the site of injection. This suggests that the scw protein is critical to the local response to dpp RNA.

(Neul and Ferguson, 1995)

scw and dpp act together to establish distinct response boundaries within the dorsal half of the embryo, perhaps by forming heterodimers that have a higher activity than homodimers of either molecule alone.

(Arora et al., 1994)

scw alleles display relative phenotypic strengths, this may be correlated to the progressive loss of dorsal pattern elements in the ventralised mutants.

(Arora and Nusslein-Volhard, 1992)

scw has been molecularly characterised.

(Arora et al., 1992)

scw is required for the normal ontogeny of the zen pattern and fating of the amnioserosa.

(Ray et al., 1991)

Involved in the regulatory hierarchy responsible for the asymmetric distribution and function of zygotic regulatory gene products along the DV axis of early embryos. scw mutants exhibit a weak ventralising phenotype in which the maintenance of the zen pattern is affected.

(Rushlow and Levine, 1990)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 41 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

46000

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P54631

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

X2JB15

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0005590

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0005590

DRscDB

46000/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0005590

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

scw_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31695

Flygut - An atlas of the Drosophila adult midgut

FBgn0005590

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

46000

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG31695

MARRVEL_MODEL

46000

modMine - A data warehouse for the modENCODE project

FBgn0005590

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P54631

Linkouts

BioGRID - A database of protein and genetic interactions.

70052

DroID - A comprehensive database of gene and protein interactions.

FBgn0005590

DRSC - Results frm RNAi screens

FBgn0005590

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG31695-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0005590

FlyMine - An integrated database for Drosophila genomics

FBgn0005590

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

BcDNA:LD30945

CG31695

(Hosono et al., 2015, Keleman et al., 2009.8.5, Brandt, 2006)

DmSCW

(Wisotzkey and Newfeld, 2020)

SCW

(Bickel et al., 2008)

Scw

(Madamanchi et al., 2021, Negreiros et al., 2018, Upadhyay et al., 2017, Matsuda et al., 2016, Tauscher et al., 2016, Bier and De Robertis, 2015, Ting et al., 2014, Mbodj et al., 2013, Sawala et al., 2012, Peluso et al., 2011, Wang et al., 2008, Pistillo and Desplan, 2007, Dudu, 2006, Umulis et al., 2006, Wang and Ferguson, 2004)

l(2)37Ff

(Jones and McGinnis, 1993)

l(2)IG76

mor2

(Weyers et al., 2011)

screw

(Gautam et al., 2021)

Name Synonyms

Screw

(Destalminil-Letourneau et al., 2021, Shimmi and Newfeld, 2013, Umulis et al., 2010, Bickel et al., 2008, Wang et al., 2008, Fritsch and Ray, 2007, Stathopoulos and Levine, 2005, Gim et al., 2001)

morphological defects 2

(Weyers et al., 2011)

screw

(Wieschaus and Nüsslein-Volhard, 2016, Heimiller et al., 2014, Künnapuu et al., 2014, Wotton et al., 2013, Weyers et al., 2011, Salzer et al., 2010, Wright et al., 2010, Twombly et al., 2009, Anderson et al., 2006, Arora, 1994.11.23)

Secondary FlyBase IDs

FBgn0002053
FBgn0003343
FBgn0046219
FBgn0051695

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (196)

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