FlyBase Gene Report: Dmel\mav

General Information

Symbol

Dmel\mav

Species

D. melanogaster

Name

maverick

Annotation Symbol

CG1901

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039914

Gene Model Status

Current

Stock Availability

21 publicly available

Gene Summary

maverick (mav) encodes a protein involved in the BMP signaling pathway. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

102D1-102D1

Sequence location

4:623,219..626,031 [-]

Recombination map

4-0

RefSeq locus

NC_004353 REGION:623219..626031

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

NCBI

UCSC

Ensembl

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables cytokine activity

inferred from biological aspect of ancestor with PANTHER:PTN000218063

(GO Reference Genome Project, 2011-)

enables growth factor activity

inferred from electronic annotation with InterPro:IPR001839, InterPro:IPR017948

(InterPro Project Members, 2004-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in BMP signaling pathway

inferred from mutant phenotype

(Fuentes-Medel et al., 2012)

involved_in positive regulation of neuromuscular junction development

inferred from mutant phenotype

(Fuentes-Medel et al., 2012)

involved_in regulation of dendrite development

inferred from mutant phenotype

(Hoyer et al., 2018)

involved_in regulation of imaginal disc-derived wing size

inferred from mutant phenotype

(Hevia and de Celis, 2013)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in BMP signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN008528320

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in extracellular region

inferred from direct assay

(Hoyer et al., 2018)

located_in synaptic cleft

inferred from direct assay

(Fuentes-Medel et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in extracellular region

inferred from electronic annotation with InterPro:IPR015615

(InterPro Project Members, 2004-)

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN000218063

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

BONE MORPHOGENETIC PROTEINS

Pathway (FlyBase)

BMP SIGNALING PATHWAY CORE COMPONENTS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

maverick (mav) encodes a protein involved in the BMP signaling pathway. [Date last reviewed: 2019-09-26]

Gene Group (FlyBase)

BONE MORPHOGENETIC PROTEINS -: Bone Morphogenetic Proteins (BMPs) are a subfamily of the Transforming Growth Factor (TGF)-β family - a group of extracellular ligands for the TGF-β-Receptor family. The binding of a BMP dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)

Pathway (FlyBase)

BMP SIGNALING PATHWAY CORE COMPONENTS -: The Bone Morphogenetic Protein (BMP) signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of a BMP family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)

Summary (Interactive Fly)

TGFβ family ligand - concentrated in the foregut - broad expression pattern suggests that signaling could be permissive rather than instructive during stomatogastric nervous system precursor migration - neuromuscular junction glia release Maverick, which likely activates the muscle activin-type receptor Punt to potently modulate Gbb-dependent retrograde signaling and synaptic growth

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\mav for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V4E6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

mav-RA

FBtr0089103

NM_079887

2705

701

Additional Transcript Data and Comments

Reported size (kB)

2.8 (northern blot)

(Nguyen et al., 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

mav-PA

FBpp0088172

81.1

701

10.38

Q9V4E6

NP_524626

AAF59328

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

701, 433 (aa)

(Nguyen et al., 2000)

Comments

mav protein belongs to the TGF-β superfamily but is not easily assigned to either the TGF-β, the BMP or activin subfamilies. It shows the highest sequence similarity with BMP-related ligands from other organisms.

(Nguyen et al., 2000)

The shorter predicted mav protein isoform lacks a signal sequence suggesting that it may not be secreted.

(Nguyen et al., 2000)

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mav using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.94

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 4

organism | uniform

Comment: maternal contribution

(Nguyen et al., 2000)

embryonic stage 4

primordial germ cell

(Nguyen et al., 2000)

embryonic stage 5

organism | ubiquitous

(Nguyen et al., 2000)

embryonic stage 5 -- 11

organism | ubiquitous

(Nguyen et al., 2000)

embryonic stage 6 -- 11

organism | ubiquitous

Comment: expressed at low levels

(Nguyen et al., 2000)

embryonic stage 7 -- 9

endoderm

(Nguyen et al., 2000)

mesoderm

(Nguyen et al., 2000)

embryonic stage 9 -- 10

inclusive hindgut primordium

(Nguyen et al., 2000)

posterior midgut primordium

(Nguyen et al., 2000)

hindgut proper primordium

(Nguyen et al., 2000)

embryonic stage 11

anterior midgut primordium

(Nguyen et al., 2000)

foregut primordium

(Nguyen et al., 2000)

embryonic stage 11 -- 12

embryonic foregut

(Nguyen et al., 2000)

embryonic stage 11 -- 14

epidermis | dorso-lateral | segmentally repeated

(Nguyen et al., 2000)

embryonic stage 12

embryonic hindgut | restricted

(Nguyen et al., 2000)

embryonic/larval pharynx | precursor

(Nguyen et al., 2000)

esophagus primordium

(Nguyen et al., 2000)

embryonic stage 12 -- 17

pharynx

(Nguyen et al., 2000)

embryonic esophagus

(Nguyen et al., 2000)

embryonic hindgut

(Nguyen et al., 2000)

embryonic stage 13

visceral trunk mesoderm of embryonic/larval posterior midgut

(Nguyen et al., 2000)

visceral trunk mesoderm of embryonic/larval anterior midgut

(Nguyen et al., 2000)

embryonic stage 13 -- 14

visceral trunk mesoderm | intense

(Nguyen et al., 2000)

embryonic stage 13 -- 17

embryonic/larval gut | faint

(Nguyen et al., 2000)

adult stage | male

testis | apical

(Schulz et al., 2004)

oogenesis stage S10 & adult stage | female

nurse cell

(Nguyen et al., 2000)

adult stage oogenesis stage S10 -- S14

oocyte

(Nguyen et al., 2000)

nurse cell

(Nguyen et al., 2000)

oogenesis stage S10 -- S14 & adult stage | female

oocyte

(Nguyen et al., 2000)

spermatogenesis

male germline stem cell

(Schulz et al., 2004)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Nguyen et al., 2000)

embryonic stage 1 -- third instar larval stage & adult stage

organism

Comment: P-stage not assayed

(Nguyen et al., 2000)

adult stage | male

organism

(Nguyen et al., 2000)

adult stage | female

organism

(Nguyen et al., 2000)

Additional Descriptive Data

Expression is observed in early germ cells in the apical testis tip.

(Schulz et al., 2004)

Marker for

male germline stem cell

(Schulz et al., 2004)

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular region

inferred from direct assay

(Hoyer et al., 2018)

located_in synaptic cleft

inferred from direct assay

(Fuentes-Medel et al., 2012)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\mav in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\mav

View exonic expression by tissue for Dmel\mav

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43804/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039914

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039914

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039914

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1901

Flygut - An atlas of the Drosophila adult midgut

FBgn0039914

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 18 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of mav

Transgenic constructs containing regulatory region of mav

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(4)C1-10a

(Podemski et al., 2004)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

mav^GD9672

viable

mav^ko

viable, with Scer\GAL4^Mef2.PR

mav^GD9672

Sterility

Allele

female fertile

female fertile (with Df(4)ED6380)

female fertile (with Df(4)ED6382)

fertile

mav^ko

Other Phenotypes

Allele

abnormal circadian rhythm, with Scer\GAL4^P2.4.Pdf

mav^HMS01125

abnormal circadian rhythm | heat sensitive, with Scer\GAL4^tim.PE, Scer\GAL80^Pdf.PS

mav^HMS01125

abnormal neuroanatomy | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4^Act.PU

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^GMR10C11

mav^UAS.cFa

abnormal neuroanatomy | third instar larval stage

mav^ko

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^A58

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^en-e16E

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^Gli-rL82

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^NP0022

abnormal size | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4^Act.PU

abnormal size | embryonic stage, with Scer\GAL4^GMR10C11

mav^UAS.cFa

abnormal size | third instar larval stage

mav^ko

abnormal size | third instar larval stage, with Scer\GAL4^A58

abnormal size | third instar larval stage, with Scer\GAL4^en-e16E

abnormal size | third instar larval stage, with Scer\GAL4^NP0022

some die during pupal stage, with Scer\GAL4^pnr-MD237

mav^GD9672

Phenotype manifest in

Allele

bouton | third instar larval stage, with Scer\GAL4^Gli-rL82

dendritic tree | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4^Act.PU

dendritic tree | third instar larval stage

mav^ko

dendritic tree | third instar larval stage, with Scer\GAL4^A58

dendritic tree | third instar larval stage, with Scer\GAL4^en-e16E

dendritic tree | third instar larval stage, with Scer\GAL4^NP0022

embryo, with Scer\GAL4^GMR10C11

mav^UAS.cFa

embryonic/larval gut, with Scer\GAL4^GMR10C11

mav^UAS.cFa

embryonic/larval hypocerebral ganglion | embryonic stage, with Scer\GAL4^GMR10C11

mav^UAS.cFa

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^Gli-rL82

embryonic proventricular ganglion, with Scer\GAL4^GMR10C11

mav^UAS.cFa

embryonic proventriculus, with Scer\GAL4^GMR10C11

mav^UAS.cFa

larval multidendritic class IV neuron | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4^Act.PU

larval multidendritic class IV neuron | third instar larval stage

mav^ko

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^A58

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^en-e16E

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^NP0022

paraesophageal ganglion | embryonic stage, with Scer\GAL4^GMR10C11

mav^UAS.cFa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (33)

Hsap\BMP5

3 of 14

Yes

Hsap\BMP6

3 of 14

Yes

Hsap\BMP7

3 of 14

Yes

Hsap\BMP8A

3 of 14

Yes

Hsap\BMP8B

3 of 14

Yes

Hsap\GDF15

3 of 14

Yes

Hsap\NODAL

3 of 14

Yes

Hsap\TGFB1

3 of 14

Yes

Hsap\TGFB2

3 of 14

Yes

Hsap\TGFB3

3 of 14

Yes

Hsap\AMH

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\BMP15

2 of 14

Yes

Hsap\GDF1

2 of 14

Yes

Hsap\GDF2

2 of 14

Yes

Hsap\GDF3

2 of 14

Yes

Hsap\GDF5

2 of 14

Yes

Hsap\GDF6

2 of 14

Yes

Hsap\GDF7

2 of 14

Yes

Hsap\GDF9

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (32)

Rnor\Bmp6

3 of 14

Yes

Rnor\Bmp8a

3 of 14

Yes

Rnor\Bmp8b

3 of 14

Yes

Rnor\Nodal

3 of 14

Yes

Rnor\Tgfb1

3 of 14

Yes

Rnor\Tgfb2

3 of 14

Yes

Rnor\Tgfb3

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Rnor\Bmp15

2 of 14

Yes

Rnor\Gdf1

2 of 14

Yes

Rnor\Gdf3

2 of 14

Yes

Rnor\Gdf5

2 of 14

Yes

Rnor\Gdf6

2 of 14

Yes

Rnor\Gdf9

2 of 14

Yes

Rnor\Gdf11

2 of 14

Rnor\Gdf15

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Rnor\Gdf2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (33)

Mmus\Bmp5

3 of 14

Yes

Mmus\Bmp6

3 of 14

Yes

Mmus\Bmp7

3 of 14

Yes

Mmus\Bmp8a

3 of 14

Yes

Mmus\Bmp8b

3 of 14

Yes

Mmus\Nodal

3 of 14

Yes

Mmus\Tgfb1

3 of 14

Yes

Mmus\Tgfb2

3 of 14

Yes

Mmus\Tgfb3

3 of 14

Yes

Mmus\Amh

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Mmus\Gdf2

2 of 14

Yes

Mmus\Gdf3

2 of 14

Yes

Mmus\Gdf5

2 of 14

Yes

Mmus\Gdf6

2 of 14

Yes

Mmus\Gdf9

2 of 14

Yes

Mmus\Gdf10

2 of 14

Mmus\Gdf11

2 of 14

Mmus\Gdf15

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Mmus\Gdf7

1 of 14

Mmus\Inha

1 of 14

Mmus\Lefty2

1 of 14

Xenopus tropicalis (Western clawed frog) (43)

Xtro\bmp5

2 of 13

Yes

Xtro\bmp6

2 of 13

Yes

Xtro\bmp7.2

2 of 13

Yes

Xtro\bmp8

2 of 13

Yes

Xtro\LOC101734287

2 of 13

Yes

Xtro\tgfb1

2 of 13

Yes

Xtro\tgfb2

2 of 13

Yes

Xtro\admp2

1 of 13

Yes

Xtro\admp

1 of 13

Yes

Xtro\amh

1 of 13

Yes

Xtro\arpin

1 of 13

Yes

Xtro\artn

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\gdf2

1 of 13

Yes

Xtro\gdf3

1 of 13

Yes

Xtro\gdf5

1 of 13

Yes

Xtro\gdf6

1 of 13

Yes

Xtro\gdf7

1 of 13

Yes

Xtro\gdf9

1 of 13

Yes

Xtro\gdf15

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC101734157

1 of 13

Yes

Xtro\LOC101734231

1 of 13

Yes

Xtro\mreg

1 of 13

Yes

Xtro\mstn.1

1 of 13

Xtro\nid1

1 of 13

Xtro\nodal2

1 of 13

Yes

Xtro\nodal3.1

1 of 13

Yes

Xtro\nodal3.2

1 of 13

Yes

Xtro\nodal5

1 of 13

Yes

Xtro\nodal

1 of 13

Yes

Xtro\nrtn

1 of 13

Yes

Xtro\poldip2

1 of 13

Xtro\pspn

1 of 13

Yes

Xtro\wdr88

1 of 13

Yes

Danio rerio (Zebrafish) (43)

Drer\bmp6

3 of 14

Yes

Drer\bmp7a

3 of 14

Yes

Drer\bmp7b

3 of 14

Yes

Drer\bmp8a

3 of 14

Yes

Drer\tgfb1a

3 of 14

Yes

Drer\tgfb2

3 of 14

Yes

Drer\tgfb3

3 of 14

Yes

Drer\admp

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\gdf2

2 of 14

Yes

Drer\gdf3

2 of 14

Yes

Drer\gdf5

2 of 14

Yes

Drer\gdf6a

2 of 14

Yes

Drer\gdf6b

2 of 14

Yes

Drer\gdf10a

2 of 14

Drer\gdf10b

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\spaw

2 of 14

Yes

Drer\tgfb1b

2 of 14

Drer\tgfb5

2 of 14

Drer\amh

1 of 14

Yes

Drer\bmp10l

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\unc-129

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Anopheles gambiae (African malaria mosquito) (6)

Agam\AgaP_AGAP012076

7 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:mav. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

daw

4 of 13

dpp

4 of 13

gbb

4 of 13

scw

4 of 13

Actβ

3 of 13

myo

3 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 7 )

Human Ortholog

Disease

Evidence

References

NODAL; nodal growth differentiation factor

model of visceral heterotaxy 5

IEA

(FlyBase, 2019-)

TGFB1; transforming growth factor beta 1

model of cystic fibrosis

IEA

(FlyBase, 2019-)

model of Camurati-Engelmann disease

IEA

(FlyBase, 2019-)

TGFB3; transforming growth factor beta 3

model of arrhythmogenic right ventricular dysplasia 1

IEA

(FlyBase, 2019-)

model of Loeys-Dietz syndrome 5

IEA

(FlyBase, 2019-)

TGFB2; transforming growth factor beta 2

model of Loeys-Dietz syndrome 4

IEA

(FlyBase, 2019-)

model of Camurati-Engelmann disease

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

mav^GL01025

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Varadarajan et al., 2015)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

BMP5; bone morphogenetic protein 5

3 of 14

112265

BMP6; bone morphogenetic protein 6

3 of 14

112266

IRON OVERLOAD, SUSCEPTIBILITY TO; IO

BMP7; bone morphogenetic protein 7

3 of 14

BONE MORPHOGENETIC PROTEIN 7; BMP7

BMP8A; bone morphogenetic protein 8a

3 of 14

620847

BMP8B; bone morphogenetic protein 8b

3 of 14

602284

GDF15; growth differentiation factor 15

3 of 14

605312

HYPEREMESIS GRAVIDARUM, SUSCEPTIBILITY TO; HG

NODAL; nodal growth differentiation factor

3 of 14

601265

HETEROTAXY, VISCERAL, 5, AUTOSOMAL; HTX5

visceral heterotaxy 5

TGFB1; transforming growth factor beta 1

3 of 14

190180

TGFB2; transforming growth factor beta 2

3 of 14

190220

TGFB3; transforming growth factor beta 3

3 of 14

190230

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

mav

comigration in sds page, molecular weight, western blot

(Myers et al., 2018)

mav - Gfrl

anti tag coimmunoprecipitation, western blot

(Myers et al., 2018)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

mav

suppressible

gbb

(Fuentes-Medel et al., 2012)

mav

suppressible

Ret

(Hoyer et al., 2018)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Ret

enhanceable

mav

(Hoyer et al., 2018)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68636

DroID - A comprehensive database of gene and protein interactions.

FBgn0039914

Pathways

Signaling Pathways (FlyBase)

BMP SIGNALING PATHWAY CORE COMPONENTS

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q59DQ3

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

4-0

Cytogenetic map

102D1-102D1

Sequence location

4:623,219..626,031 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

102D1-102D1

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

102C-102C

(Nguyen, 2000.4.4)

102C-102C

(determined by in situ hybridisation)

(Nguyen et al., 2000)

Experimentally Determined Recombination Data

Location

4-0

(FlyBase, 2016)

(Nguyen et al., 2000)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (21)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

60780

y¹; Mi{MIC}mav^MI05038

97111

y¹ w¹¹¹⁸; P{UAS-mav.G}2

97112

y¹ w¹¹¹⁸; P{UAS-mav.G}3

602202

y¹ w¹¹¹⁸; TI{TI}FRT101F mav^B

605794

y¹ w¹¹¹⁸; TI{TI}FRT101F mav^D

Kyoto

118856

y¹ w¹¹¹⁸; P{UAS-mav.G}2

118857

y¹ w¹¹¹⁸; P{UAS-mav.G}3

119168

y¹ w¹¹¹⁸; TI{TI}FRT101F mav^B

1901R-3

1901R-4

v330592

v318248

PBac{fTRG00891.sfGFP-TVPTBF}VK00033

More stocks available...

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (147)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE69013

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039914

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039914

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Fuentes-Medel et al., 2012)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Source for identity of mav CG1901 was sequence comparison ( date:000829 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: mav CG1901

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG1901

(Meadows, 2018.10.31, Koya and Meller, 2015, Ni et al., 2011.7.19, Mosallanejad et al., 2010, Ni et al., 2010.12.1)

DmMav

(Wisotzkey and Newfeld, 2020)

MAV

(Bickel et al., 2008, Gesualdi and Haerry, 2007)

Mav

(Bastin and Eleftherianos, 2023, Upadhyay et al., 2017, Koya and Meller, 2015, Ting et al., 2014, Corty and Freeman, 2013, Fuentes-Medel et al., 2012, Serpe and O'Connor, 2006, Ellis et al., 2005, Sousa-Neves et al., 2005)

TGF-b

(Hatfield et al., 2002)

Name Synonyms

DmMaverick

(Wisotzkey and Newfeld, 2020)

Maverick

(Tay and Pek, 2019, Ting et al., 2014, Fuentes-Medel et al., 2012, Bickel et al., 2008, Gesualdi and Haerry, 2007)

maverick

(Destalminil-Letourneau et al., 2021, Varadarajan et al., 2015, Nguyen, 2000.4.4, Nguyen et al., 2000)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 58 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43804

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V4E6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V4E6

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43804/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039914

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039914

FlyMine - An integrated database for Drosophila genomics

FBgn0039914

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1901

MARRVEL_MODEL - MARRVEL (model organism gene)

43804

Linkouts

BioGRID - A database of protein and genetic interactions.

68636

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039914

DroID - A comprehensive database of gene and protein interactions.

FBgn0039914

DRSC - Results frm RNAi screens

FBgn0039914

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039914

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039914

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1901

Flygut - An atlas of the Drosophila adult midgut

FBgn0039914

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004299

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q59DQ3

References (82)

The following external sites may use different assemblies or annotations than FlyBase.

-0.94

Report Sections