FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene Group: BONE MORPHOGENETIC PROTEINS
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General Information
Name
BONE MORPHOGENETIC PROTEINS
Species
D. melanogaster
Symbol
BMP-TGF
FlyBase ID
FBgg0001088
Date last reviewed
2019-05-08
Number of members
4
Description
Description
Bone Morphogenetic Proteins (BMPs) are a subfamily of the Transforming Growth Factor (TGF)-β family - a group of extracellular ligands for the TGF-β-Receptor family. The binding of a BMP dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
Notes on Group

Based on sequence, mav is divergent from the BMP and activin TGF-β sub-families (FBrf0236482). Here it has been classed as a BMP-type ligand for the following reasons: 1. In FBrf0219680 it appears to signal through the BMP type-I receptor Thickveins (tkv) to activate Mad. 2. In S2 cells, mav does not activate Smox - the activin pathway-restricted Smad (FBrf0205031).

Source Material
The BONE MORPHOGENETIC PROTEINS Gene Group has been compiled using the following publication(s): Upadhyay et al., 2017 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Cellular Component
Related Gene Groups
Parent group(s)
TRANSFORMING GROWTH FACTOR-BETA FAMILY
Other related group(s)
BMP SIGNALING PATHWAY CORE COMPONENTS
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
BMP-TGF
BONE MORPHOGENETIC PROTEINS
BMPs
Secondary FlyBase ID(s)
References (2)