FlyBase Allele Report: Dmel\mav[GL01025]

General Information

Symbol

Dmel\mav^GL01025

Species

D. melanogaster

Name

FlyBase ID

FBal0266347

Feature type

allele

Associated gene

Dmel\mav

Associated Insertion(s)

Carried in Construct

P{TRiP.GL01025}

Also Known As

UAS-mav^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL01025}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL01025

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Varadarajan et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^A58

(Hoyer et al., 2018)

abnormal size | third instar larval stage, with Scer\GAL4^A58

(Hoyer et al., 2018)

Phenotype Manifest In

dendritic tree | third instar larval stage, with Scer\GAL4^A58

(Hoyer et al., 2018)

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^A58

(Hoyer et al., 2018)

Detailed Description

Statement

Reference

The expression of mav^GL01025 under the control of Scer\GAL4^A58 leads to third instar larval C4da neurons exhibiting a less complex dendrite tree (i.e. less dendritic coverage and shorter dendrites and fewer branches), as compared to controls.

(Hoyer et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

mav^GL01025, Scer\GAL4^elav-C155 is a suppressor of abnormal neuroanatomy | adult stage | progressive phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Varadarajan et al., 2015)

mav^GL01025, Scer\GAL4^elav-C155 is a suppressor of decreased cell number | adult stage | progressive phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Varadarajan et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

mav^GL01025, Scer\GAL4^elav-C155 is a suppressor of rhabdomere of eye photoreceptor cell | adult stage | progressive phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Varadarajan et al., 2015)

mav^GL01025, Scer\GAL4^elav-C155 is a suppressor of eye photoreceptor cell | adult stage | progressive phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Varadarajan et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of mav^GL01025 ameliorates the rhabdomere and photoreceptor neuron loss seen in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155.

(Varadarajan et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

36809

y¹ sc^* v¹ sev²¹; P{TRiP.GL01025}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

mav^GL01025

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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