FlyBase Allele Report: Dmel\sax[CA.UAS.cUa]

General Information

Symbol

Dmel\sax^CA.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0154655

Feature type

allele

Associated gene

Dmel\sax

Associated Insertion(s)

Carried in Construct

P{UAS-sax.CA.U}

Also Known As

UAS-sax^Act

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-sax.CA.U}

Cytology

Description

UAS regulatory sequences drive expression of an activated form of sax.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

sax

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis type 1

modeled by Sod1^G85R

(Held et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^Bx-MS1096

(Kang and Bier, 2010)

Phenotype Manifest In

wing vein | ectopic, with Scer\GAL4^Bx-MS1096

(Kang and Bier, 2010)

Detailed Description

Statement

Reference

Expression of sax^A.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 results in an ectopic wing vein phenotype.

(Kang and Bier, 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Scer\GAL4^Bx-MS1096, sax^CA.UAS.cUa has visible phenotype, non-suppressible by Scer\GAL4^Bx-MS1096, sax^CA.UAS.cUa

(Kang and Bier, 2010)

Scer\GAL4^Bx-MS1096, sax^CA.UAS.cUa has visible phenotype, non-suppressible by Hip14^UAS.cKa, Scer\GAL4^Bx-MS1096

(Kang and Bier, 2010)

Suppressor of

Statement

Reference

sax^CA.UAS.cUa, Scer\GAL4^GMR.PF is a suppressor of abnormal neuroanatomy phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Saja et al., 2010)

sax^CA.UAS.cUa, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Bx-MS1096, sax^CA.UAS.cUa is a non-suppressor of visible phenotype of Scer\GAL4^Bx-MS1096, sax^CA.UAS.cUa

(Kang and Bier, 2010)

Other

Statement

Reference

Scer\GAL4^unspecified, sax^CA.UAS.cUa, tkv^CA.UAS.cUa has abnormal neuroanatomy | somatic clone | larval stage phenotype

(Kaneko et al., 2024)

Scer\GAL4^CCAP.PP, sax^CA.UAS.cUa, tkv^CA.UAS.cUa has partially lethal - majority live phenotype

(Veverytsa and Allan, 2011)

Scer\GAL4^CCAP.PP, sax^CA.UAS.cUa, tkv^CA.UAS.cUa, wit^B11/wit^A12 has lethal - all die before end of P-stage phenotype

(Veverytsa and Allan, 2011)

Scer\GAL4^CCAP.PP, sax^CA.UAS.cUa, tkv^CA.UAS.cUa, wit^B11/wit^A12 has majority die during larval stage phenotype

(Veverytsa and Allan, 2011)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Scer\GAL4^Bx-MS1096, sax^CA.UAS.cUa has wing vein | ectopic phenotype, non-suppressible by Scer\GAL4^Bx-MS1096, sax^CA.UAS.cUa

(Kang and Bier, 2010)

Scer\GAL4^Bx-MS1096, sax^CA.UAS.cUa has wing vein | ectopic phenotype, non-suppressible by Hip14^UAS.cKa, Scer\GAL4^Bx-MS1096

(Kang and Bier, 2010)

Suppressor of

Statement

Reference

Scer\GAL4^CCAP.PP, tkv^CA.UAS.cUa, sax^CA.UAS.cUa is a suppressor | partially of pupa phenotype of wit^B11/wit^A12

(Veverytsa and Allan, 2011)

sax^CA.UAS.cUa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Saja et al., 2010, Buff et al., 2007)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Bx-MS1096, sax^CA.UAS.cUa is a non-suppressor of wing vein | ectopic phenotype of Scer\GAL4^Bx-MS1096, sax^CA.UAS.cUa

(Kang and Bier, 2010)

Other

Statement

Reference

Scer\GAL4^unspecified, sax^CA.UAS.cUa, tkv^CA.UAS.cUa has axon terminus | somatic clone | larval stage phenotype

(Kaneko et al., 2024)

Scer\GAL4^unspecified, sax^CA.UAS.cUa, tkv^CA.UAS.cUa has larval nociceptive neuropil | somatic clone phenotype

(Kaneko et al., 2024)

Scer\GAL4^unspecified, sax^CA.UAS.cUa, tkv^CA.UAS.cUa has larval multidendritic class IV neuron phenotype

(Kaneko et al., 2024)

Scer\GAL4^CCAP.PP, sax^CA.UAS.cUa, tkv^CA.UAS.cUa has wing phenotype

(Veverytsa and Allan, 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of either sog^Scer\UAS.cYa or Hip14^Scer\UAS.cKa does not suppress the ectopic wing vein phenotype caused by expression of sax^A.Scer\UAS under the control of Scer\GAL4^Bx-MS1096.

(Kang and Bier, 2010)

Overexpression of sax^A.Scer\UAS suppresses the adult visual system degeneration seen in Scer\GAL4^GMR.PF, Ppt1^Scer\UAS.cKa flies.

(Saja et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

sax^A.Scer\UAS

sax^A.UAS

sax^CA.UAS.cUa

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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