FB2026_03 , released September 17, 2026
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Citation
Kanwar, R., Fortini, M.E. (2004). Notch Signaling: A Different Sort Makes the Cut.  Curr. Biol. 14(24): R1043--R1045.
FlyBase ID
FBrf0188484
Publication Type
Note
Abstract
Notch signaling is regulated by ubiquitination of the receptor and its extracellular ligands. New studies reveal distinct ubiquitination-dependent endosomal sorting pathways in which ligand-bound Notch is activated while unliganded Notch is recycled or degraded, facilitating signaling while preventing inappropriate activation of unstimulated receptors.
PubMed ID
15620635
PubMed Central ID
DOI
10.1016/j.cub.2004.11.041
Related Publication(s)
Research paper

Drosophila Nedd4 regulates endocytosis of Notch and suppresses its ligand-independent activation.
Sakata et al., 2004, Curr. Biol. 14(24): 2228--2236 [FBrf0183817]

Regulation of Notch endosomal sorting and signaling by Drosophila Nedd4 family proteins.
Wilkin et al., 2004, Curr. Biol. 14(24): 2237--2244 [FBrf0183818]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference
    Genes (8)