FlyBase Allele Report: Dmel\spin[Δ29]

General Information

Symbol

Dmel\spin^Δ29

Species

D. melanogaster

Name

FlyBase ID

FBal0196746

Feature type

allele

Associated gene

Dmel\spin

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Dermaut et al., 2005)

Mutagen

P-element activity

(Dermaut et al., 2005)

Progenitor genotype

P{lacW}spin^k02511

(Dermaut et al., 2005)

Cytology

Description

Imprecise excision of the P{lacW} element, resulting in a 1.5kb deletion at the 5' of the spin gene.

(Dermaut et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior (with spin^N)

(Dermaut et al., 2005)

abnormal locomotor behavior (with spin^P)

(Dermaut et al., 2005)

abnormal locomotor behavior (with spin^Δ2b)

(Dermaut et al., 2005)

lethal (with Df(2R)Jp8)

(Dermaut et al., 2005)

lethal (with spin^11F5)

(Dermaut et al., 2005)

lethal (with spin^E14.1)

(Dermaut et al., 2005)

lethal (with spin^k02511)

(Dermaut et al., 2005)

lethal (with spin^N)

(Dermaut et al., 2005)

lethal (with spin^P)

(Dermaut et al., 2005)

lethal (with spin^Δ2b)

(Dermaut et al., 2005)

lethal (with spin^Δ31)

(Dermaut et al., 2005)

lethal (with spin^Δ86)

(Dermaut et al., 2005)

short lived (with spin^N)

(Dermaut et al., 2005)

short lived (with spin^P)

(Dermaut et al., 2005)

short lived (with spin^Δ2b)

(Dermaut et al., 2005)

Phenotype Manifest In

wing vein | increased number (with spin^N)

(Dermaut et al., 2005)

wing vein | increased number (with spin^P)

(Dermaut et al., 2005)

wing vein | increased number (with spin^Δ2b)

(Dermaut et al., 2005)

Detailed Description

Statement

Reference

spin^N/spin^Δ29, spin^P/spin^Δ29 and spin^Δ29/spin^Δ2b transheterozygotes show small amounts of adult escapers, depending on culture conditions. Adult escapers exhibit progressive locomotor defects, such as difficulty in righting after a fall. These defects worsen during the days after emergence and result in death within 5-12 days. The escapers appear morphologically normal except for a subtle, completely penetrant extra wing vein phenotype.

(Dermaut et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions