FlyBase Allele Report: Dmel\spin[Delta58]

General Information

Symbol

Dmel\spin^Delta58

Species

D. melanogaster

Name

FlyBase ID

FBal0093987

Feature type

allele

Associated gene

Dmel\spin

Associated Insertion(s)

Carried in Construct

Also Known As

spin^Δ58

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Bloomington Drosophila Stock Center, 1998.10.20)

Mutagen

P-element activity

(Bloomington Drosophila Stock Center, 1998.10.20)

Progenitor genotype

spin^k02511

(Bloomington Drosophila Stock Center, 1998.10.20)

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neuronal ceroid lipofuscinosis

CEA with spin¹⁰⁴⁰³

(Hebbar et al., 2017)

model of sphingolipidosis

CEA with spin¹⁰⁴⁰³

(Hebbar et al., 2017)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage | progressive (with spin¹⁰⁴⁰³)

(Hebbar et al., 2017)

lethal | recessive

(Bloomington Drosophila Stock Center, 1998.10.20)

short lived (with spin¹⁰⁴⁰³)

(Hebbar et al., 2017)

Phenotype Manifest In

adult brain | progressive (with spin¹⁰⁴⁰³)

(Hebbar et al., 2017)

lamellar body | adult stage | progressive (with spin¹⁰⁴⁰³)

(Hebbar et al., 2017)

lysosome | adult stage | progressive (with spin¹⁰⁴⁰³)

(Hebbar et al., 2017)

Detailed Description

Statement

Reference

spin¹⁰⁴⁰³/spin^Delta58 adults exhibit a progressive impairment in climbing ability, as compared to spin^Delta58 heterozygous controls.

(Hebbar et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

spin^Delta58/spin¹⁰⁴⁰³ has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible | partially by CDase^UAS.cRa/Scer\GAL4^spin.PN

(Hebbar et al., 2017)

Suppressor of

Statement

Reference

spin[+]/spin^Delta58 is a suppressor | partially of visible | adult stage phenotype of Mitf^UAS.cZa, Scer\GAL4^dpp.blk1

(Zhang et al., 2015)

Phenotype Manifest In

Enhanced by

Statement

Reference

spin^Delta58/spin¹⁰⁴⁰³ has adult brain | progressive phenotype, enhanceable by CDase[+]/CDase^slab-2

(Hebbar et al., 2017)

Suppressor of

Statement

Reference

spin[+]/spin^Delta58 is a suppressor | partially of wing | adult stage phenotype of Mitf^UAS.cZa, Scer\GAL4^dpp.blk1

(Zhang et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The small underdeveloped wing characteristic for adult flies expressing Mitf^Scer\UAS.cZa under the control of Scer\GAL4^dpp.blk1 is significantly suppressed by combination with a single copy of spin^Delta58.

(Zhang et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

4378

w^67c23; spin^Delta58/CyO, P{en1}wg^en11

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

bnch^Delta58

spin⁵⁸

(Hebbar et al., 2017)

spin^Delta58

spin^Δ58

(Hebbar et al., 2017, Milton et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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