FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Mitf
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General Information
Symbol
Dmel\Mitf
Species
D. melanogaster
Name
Mitf
Annotation Symbol
CG43369
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263112
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Summary
Mitf (Mitf) encodes a b-HLH-Zip transcription factor that regulates basic cellular processes in part by controlling the expression of the vacuolar (H+)-ATPase subunits. [Date last reviewed: 2018-10-04] (FlyBase Gene Snapshot)
All Summaries
Also Known As

TFEB, dMitf

Key Links
Genomic Location
Cytogenetic map
102F8-102F8
Sequence location
Recombination map
4-0
RefSeq locus
NC_004353 REGION:1198852..1224467
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
Function
Gene Ontology (GO) Annotations (16 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from direct assay
(Zhang et al., 2024)
enables sequence-specific DNA binding
inferred from direct assay
(Zhang et al., 2015)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN005248237
(GO Reference Genome Project, 2011-)
enables protein dimerization activity
inferred from electronic annotation with InterPro:IPR011598, InterPro:IPR036638
(InterPro Project Members, 2004-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN005248237
(GO Reference Genome Project, 2011-)
Biological Process (10 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
involved_in cellular response to starvation
inferred from mutant phenotype
(Bouché et al., 2016)
involved_in compound eye morphogenesis
inferred from mutant phenotype
(Hallsson et al., 2004)
involved_in imaginal disc morphogenesis
inferred from genetic interaction with FLYBASE:yki; FB:FBgn0034970
(Zhang et al., 2024)
involved_in lipid catabolic process
inferred from mutant phenotype
(Bouché et al., 2016)
involved_in lysosome organization
inferred from mutant phenotype
(Bouché et al., 2016)
involved_in positive regulation of autophagosome maturation
inferred from mutant phenotype
(Bouché et al., 2016)
involved_in positive regulation of DNA-templated transcription
inferred from mutant phenotype
(Bouché et al., 2016, Zhang et al., 2015)
involved_in positive regulation of transcription by RNA polymerase II
inferred from direct assay
(Zhang et al., 2024)
involved_in regulation of DNA-templated transcription
inferred from direct assay
(Hallsson et al., 2004)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN005248237
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN005248237
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Mitf (Mitf) encodes a b-HLH-Zip transcription factor that regulates basic cellular processes in part by controlling the expression of the vacuolar (H+)-ATPase subunits. [Date last reviewed: 2018-10-04]
Gene Group (FlyBase)
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -
Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).
Summary (Interactive Fly)

bHLH transcription factor - regulates of eye development - controls transcription of all 15 vacuolar-ATPase components - modulator of metabolism for cellular homeostasis - Mitf, vacuolar-ATPase and TORC1 form a negative regulatory loop that maintains each of these important metabolic regulators in relative balance - control of lysosomal-autophagy pathway

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Mitf for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry C3KGP2)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Mitf-RA
FBtr0307326
NM_001038719
4032
730
Mitf-RB
FBtr0307327
NM_001038718
3009
730
Mitf-RC
FBtr0307328
NM_001258507
3226
837
Mitf-RD
FBtr0307329
NM_001258508
3948
704
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Mitf-PA
FBpp0298327
80.9
730
5.25
Q6WSQ9
NP_001033808
ABC65834
Mitf-PB
FBpp0298328
80.9
730
5.25
Q6WSQ9
NP_001033807
ABC65835
Mitf-PC
FBpp0298329
92.4
837
5.62
C3KGP2
NP_001245436
AFH06796
Mitf-PD
FBpp0298330
78.2
704
5.32
H9XVQ2
NP_001245437
AFH06797
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

730 aa isoforms: Mitf-PA, Mitf-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mitf using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.81

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
central brain anlage in statu nascendi
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
clypeo-labral primordium
(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
labral segment
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
third instar larval stage
wing disc
(Tognon et al., 2016)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Mitf in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 26 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mitf
Transgenic constructs containing regulatory region of Mitf
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene not disrupted in
Df(4)TZDC
(Zhang et al., 2015)
Inferred from location ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Df(4)C3)
lethal (with Df(4)scH)
lethal - all die before end of larval stage
lethal - all die before end of larval stage, with Scer\GAL4byn-Gal4
lethal - all die before end of larval stage, with Scer\GAL4c311
lethal - all die before end of larval stage | somatic clone - tissue specific, with Scer\GAL4Act5C.PI
Other Phenotypes
Allele
abnormal cell cycle | oogenesis, with Scer\GAL4nanos.PG
abnormal developmental rate
abnormal neuroanatomy | adult stage, with Scer\GAL4elav.PU
abnormal neuroanatomy | adult stage, with Scer\GAL4ey-OK107
abnormal neuroanatomy | larval stage | somatic clone - tissue specific, with Scer\GAL4Act5C.PI
abnormal neuroanatomy | larval stage | somatic clone - tissue specific, with Scer\GAL4GMR46D04, Scer\GAL4c311
abnormal starvation stress response | adult stage, with Scer\GAL4elav.PU
abnormal starvation stress response | adult stage, with Scer\GAL4ey-OK107
abnormal starvation stress response | third instar larval stage, with Scer\GAL4Lsp2.PH
abnormal stress response | oogenesis, with Scer\GAL4nanos.PG
decreased size | larval stage
some die during larval stage, with Scer\GAL4c311
visible | adult stage, with Scer\GAL4dpp.blk1
visible | adult stage | somatic clone, with Scer\GAL4Act5C.PI
Phenotype manifest in
Allele
adult brain, with Scer\GAL4elav.PU
adult brain, with Scer\GAL4ey-OK107
autophagosome | adult stage, with Scer\GAL4elav.PU
developing neuron | decreased number | larval stage | somatic clone - tissue specific, with Scer\GAL4Act5C.PI
developing neuron | ectopic | larval stage | somatic clone - tissue specific, with Scer\GAL4Act5C.PI
developing neuron | ectopic | larval stage | somatic clone - tissue specific, with Scer\GAL4GMR46D04, Scer\GAL4c311
eye | somatic clone - tissue specific, with Scer\GAL4Act5C.PI
eye disc, with Scer\GAL4ey.PH
eye disc | larval stage
eye disc | larval stage | somatic clone - tissue specific, with Scer\GAL4Act5C.PI
eye disc | larval stage | somatic clone - tissue specific, with Scer\GAL4GMR46D04, Scer\GAL4c311
fat body | third instar larval stage, with Scer\GAL4Lsp2.PH
female germline stem cell, with Scer\GAL4nanos.PG
lysosome | adult stage, with Scer\GAL4elav.PU
lysosome | third instar larval stage, with Scer\GAL4Lsp2.PH
mitochondrion | adult stage, with Scer\GAL4elav.PU
peripodial epithelium of eye disc | larval stage | somatic clone - tissue specific, with Scer\GAL4Act5C.PI
peripodial epithelium of eye disc | larval stage | somatic clone - tissue specific, with Scer\GAL4GMR46D04, Scer\GAL4c311
wing, with Scer\GAL4dpp.blk1
wing | adult stage, with Scer\GAL4dpp.blk1
wing disc | third instar larval stage, with Scer\GAL4en-e16E
wing disc | third instar larval stage, with Scer\GAL4nub.PK
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (11)
Hsap\MITF
11 of 14
Yes
Yes
1  
Hsap\TFE3
10 of 14
No
Yes
1  
Hsap\TFEB
10 of 14
No
Yes
1  
Hsap\TFEC
10 of 14
No
Yes
Hsap\USF1
2 of 14
No
No
Hsap\USF2
2 of 14
No
No
Hsap\MNT
1 of 14
No
No
Hsap\MXD4
1 of 14
No
No
Hsap\SREBF1
1 of 14
No
No
Hsap\SREBF2
1 of 14
No
No
5  
Hsap\TFAP4
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (15)
Rnor\Mitf
11 of 14
Yes
Yes
Rnor\Tfe3
10 of 14
No
Yes
Rnor\Tfeb
10 of 14
No
Yes
Rnor\Tfec
9 of 14
No
Yes
Rnor\Usf1
2 of 14
No
No
Rnor\Mlx
1 of 14
No
No
Rnor\Mnt
1 of 14
No
No
Rnor\Mxd4
1 of 14
No
No
Rnor\Mxi1
1 of 14
No
No
Rnor\Myc
1 of 14
No
No
Rnor\Mycs
1 of 14
No
No
Rnor\Srebf1
1 of 14
No
No
Rnor\Srebf2
1 of 14
No
No
Rnor\Tfap4
1 of 14
No
No
Rnor\Usf2
1 of 14
No
No
Mus musculus (laboratory mouse) (13)
Mmus\Mitf
11 of 14
Yes
Yes
Mmus\Tfe3
10 of 14
No
Yes
Mmus\Tfeb
10 of 14
No
Yes
Mmus\Tfec
9 of 14
No
Yes
Mmus\Usf1
2 of 14
No
No
Mmus\Usf2
2 of 14
No
No
Mmus\Mlx
1 of 14
No
No
Mmus\Mnt
1 of 14
No
No
Mmus\Mxi1
1 of 14
No
No
Mmus\Myc
1 of 14
No
No
Mmus\Srebf1
1 of 14
No
No
Mmus\Srebf2
1 of 14
No
No
Mmus\Tfap4
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (13)
Xtro\mitf
8 of 13
Yes
Yes
Xtro\tfeb
8 of 13
Yes
Yes
Xtro\tfec
8 of 13
Yes
Yes
Xtro\tfe3
6 of 13
No
Yes
Xtro\eif4h
1 of 13
No
No
Xtro\mlxip
1 of 13
No
No
Xtro\mxd3
1 of 13
No
Yes
Xtro\mxd4
1 of 13
No
Yes
Xtro\mxi1
1 of 13
No
Yes
Xtro\mycl
1 of 13
No
No
Xtro\neu3.3
1 of 13
No
Yes
Xtro\syt4
1 of 13
No
No
Xtro\usf3
1 of 13
No
Yes
Danio rerio (Zebrafish) (17)
Drer\mitfa
11 of 14
Yes
Yes
Drer\mitfb
11 of 14
Yes
Yes
Drer\tfe3b
10 of 14
No
Yes
Drer\tfeb
10 of 14
No
Yes
Drer\tfe3a
9 of 14
No
Yes
Drer\tfec
9 of 14
No
Yes
Drer\usf1
2 of 14
No
No
Drer\usf1l
2 of 14
No
No
Drer\hey1
1 of 14
No
No
Drer\LOC100535945
1 of 14
No
No
Drer\max
1 of 14
No
No
Drer\mlxip
1 of 14
No
No
Drer\mxd4
1 of 14
No
No
Drer\srebf1
1 of 14
No
No
Drer\srebf2
1 of 14
No
No
Drer\usf2
1 of 14
No
No
Drer\usf3
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\hlh-30
7 of 14
Yes
Yes
Cele\mxl-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (6)
Agam\AgaP_AGAP013107
6 of 12
Yes
Yes
Agam\AgaP_AGAP000807
2 of 12
No
Yes
Agam\AgaP_AGAP003186
2 of 12
No
No
Agam\AgaP_AGAP000076
1 of 12
No
No
Agam\AgaP_AGAP000682
1 of 12
No
No
Agam\AgaP_AGAP009806
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (6)
Atha\AIB
1 of 13
Yes
No
Atha\ALC
1 of 13
Yes
Yes
Atha\AT5G43175
1 of 13
Yes
Yes
Atha\AT5G64980
1 of 13
Yes
Yes
Atha\CIB5
1 of 13
Yes
No
Atha\SPT
1 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\RTG3
5 of 13
Yes
Yes
Scer\CBF1
2 of 13
No
No
Scer\RTG1
1 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\SPAC3F10.12c
2 of 12
Yes
No
Spom\esc1
1 of 12
No
No
Spom\sre1
1 of 12
No
No
Spom\sre2
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Mitf. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (5)
Usf
2 of 13
CG46463
1 of 13
Max
1 of 13
Mondo
1 of 13
SREBP
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
MitfKK113614
model of  lysosomal storage disease
CEA
(Bouché et al., 2016)
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 6 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
MITF; melanocyte inducing transcription factor
11 of 14
MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; MITF
 
TFE3; transcription factor binding to IGHM enhancer 3
10 of 14
314310
 
TFEB; transcription factor EB
10 of 14
T-CELL TRANSCRIPTION FACTOR EB; TFEB
       
      TFEC; transcription factor EC
      10 of 14
      604732
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          Mitf - yki
          anti tag coimmunoprecipitation, anti tag western blot
          (Zhang et al., 2024)
          Summary of Genetic Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Mitf
          suppressible
          Cka
          (Zhang et al., 2024)
          Mitf
          suppressible
          CtsL1
          (Zhang et al., 2015)
          Mitf
          suppressible
          gig
          (Zhang et al., 2015)
          Mitf
          suppressible
          hpo
          (Zhang et al., 2024)
          Mitf
          suppressible
          Lamp1
          (Zhang et al., 2015)
          Mitf
          suppressible
          mts
          (Zhang et al., 2024)
          Mitf
          suppressible
          Pp2A-29B
          (Zhang et al., 2024)
          Mitf
          suppressible
          Rab2
          (Zhang et al., 2015)
          Mitf
          suppressible
          RagC-D
          (Zhang et al., 2015)
          Mitf
          suppressible
          spin
          (Zhang et al., 2015)
          Mitf
          suppressible
          Tsc1
          (Zhang et al., 2015)
          Mitf
          suppressible
          Vha13
          (Zhang et al., 2015)
          Mitf
          suppressible
          Vha14-1
          (Zhang et al., 2015)
          Mitf
          suppressible
          Vha26
          (Zhang et al., 2015)
          Mitf
          suppressible
          Vha55
          (Zhang et al., 2015)
          Mitf
          suppressible
          Vha68-2
          (Zhang et al., 2015)
          Mitf
          suppressible
          VhaSFD
          (Zhang et al., 2015)
          Mitf
          suppressible
          wts
          (Zhang et al., 2024)
          Mitf
          suppressible
          yki
          (Zhang et al., 2024)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Rrp4
          suppressible
          Mitf
          (Yang et al., 2020)
          External Data
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyBase
          External Links
          External Data
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          4
          Recombination map
          4-0
          Cytogenetic map
          102F8-102F8
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          102F8-102F8
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          102E-102F
          (Hallsson et al., 2004)
          h59-h61
          (Drosophila Heterochromatin Genome Project, 2004)
          Experimentally Determined Recombination Data
          Location

          4-0

          (FlyBase, 2016)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (14)
          Genomic Clones (1)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (66)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Zhou et al., 2023, Tognon et al., 2016, Zhang et al., 2015)
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              Mitf directly controls transcription of all 15 v-ATPase components.

              (Zhang et al., 2015)

              Annotation CG17469 (which corresponds to Mitf) restored in release 3.2 of the genome annotation.

              (Drosophila Heterochromatin Genome Project, 2004)

              New annotation (CG41130) in release 3.2 of the genome annotation.

              (Drosophila Heterochromatin Genome Project, 2004)

              Identified with: LP03467 - LD03467 is a chimeric clone containing the 5' part of Mitf and a totally unrelated cDNA.

              (Hallsson et al., 2004)

              Annotation CG17469 was eliminated in release 3 of the genome annotation, October 2002.

              (FlyBase Genome Annotators, 2002-2003)
              Relationship to Other Genes
              Source for database merge of

              Source for merge of: MITF CG17469

              (Drosophila Heterochromatin Genome Project, 2004)

              Source for merge of: Mitf CG41130

              (FlyBase Genome Annotators, 2011)
              Additional comments

              Annotations CG17469 and CG41130 merged as CG43369 in release 5.36 of the genome annotation.

              (FlyBase Genome Annotators, 2011)
              Nomenclature History
              Source for database identify of
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (10)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 41 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              References (79)