FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Gene: Dmel\Rab2
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General Information
Symbol
Dmel\Rab2
Species
D. melanogaster
Name
Rab2
Annotation Symbol
CG3269
Feature Type
protein_coding_gene
FlyBase ID
FBgn0014009
Gene Model Status
Current
Stock Availability
21 publicly available
Gene Summary
Rab2 (Rab2) encodes a protein that belongs to the Rab family of small Ras-like GTPases that regulate vesicle trafficking. Rab2 product contributes to the maturation and fusion of endosomes and autophagosomes with lysosomes. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Drab2, DmRab2, Rab-protein 2

Key Links
Genomic Location
Cytogenetic map
42C5-42C5
Sequence location
Recombination map
2-55
RefSeq locus
NT_033778 REGION:6696739..6699469
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (29 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables GTP binding
inferred from direct assay
(Lardong et al., 2015)
enables magnesium ion binding
inferred from direct assay
(Lardong et al., 2015)
enables protein binding
inferred from physical interaction with UniProtKB:Q9VEA2
(Lőrincz et al., 2017)
(Sinka et al., 2008)
inferred from physical interaction with FLYBASE:BicD; FB:FBgn0000183
(Gillingham et al., 2014)
inferred from physical interaction with FLYBASE:Golgin104; FB:FBgn0036614
(Gillingham et al., 2014)
inferred from physical interaction with FLYBASE:Fam114A; FB:FBgn0038360
(Gillingham et al., 2014)
inferred from physical interaction with FLYBASE:Vps39; FB:FBgn0038593
(Gillingham et al., 2014)
inferred from physical interaction with FLYBASE:CG32485; FB:FBgn0052485
(Gillingham et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTP binding
inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR005225
(InterPro Project Members, 2004-)
enables GTPase activity
inferred from electronic annotation with InterPro:IPR001806
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(Gene Ontology Curators, 2002-)
Biological Process (11 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
involved_in autophagosome-lysosome fusion
inferred from mutant phenotype
(Fujita et al., 2017, Lőrincz et al., 2017)
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport
inferred from mutant phenotype
(Ke et al., 2018)
involved_in eye pigment granule organization
inferred from mutant phenotype
(Lőrincz et al., 2017)
involved_in protein secretion
inferred from genetic interaction with FLYBASE:Rab1; FB:FBgn0285937
(Ke et al., 2018)
involved_in regulation of glutamate receptor clustering
inferred from mutant phenotype
(Mallik et al., 2017)
involved_in regulation of postsynapse organization
inferred from mutant phenotype
(Mallik et al., 2017)
involved_in secretory granule-lysosome fusion
inferred from mutant phenotype
(Csizmadia et al., 2018)
involved_in symbiont entry into host cell
inferred from high throughput mutant phenotype
(Hodgson et al., 2019)
involved_in T-tubule organization
inferred from mutant phenotype
(Fujita et al., 2017)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in Rab protein signal transduction
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(Gene Ontology Curators, 2002-)
involved_in vesicle-mediated transport
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN004663565
(GO Reference Genome Project, 2011-)
Cellular Component (14 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
located_in autolysosome membrane
inferred from direct assay
(Lőrincz et al., 2017)
located_in autophagosome membrane
inferred from direct assay
(Fujita et al., 2017, Lőrincz et al., 2017)
located_in endoplasmic reticulum exit site
inferred from direct assay
(Ke et al., 2018)
located_in Golgi apparatus
inferred from direct assay
(Gillingham et al., 2014)
located_in neuronal cell body
inferred from high throughput direct assay
(Chan et al., 2011)
located_in plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
located_in postsynapse of neuromuscular junction
inferred from direct assay
(Mallik et al., 2017)
located_in type II terminal bouton
inferred from direct assay
(Mallik et al., 2017)
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
located_in cytoplasmic vesicle
inferred from experiment
(Götz et al., 2021)
is_active_in Golgi apparatus
inferred from biological aspect of ancestor with PANTHER:PTN001179054
(GO Reference Genome Project, 2011-)
located_in Golgi apparatus
inferred from experiment
(Götz et al., 2021)
is_active_in Golgi membrane
inferred from biological aspect of ancestor with PANTHER:PTN008725055
(GO Reference Genome Project, 2011-)
located_in perikaryon
inferred from experiment
(Götz et al., 2021)
located_in presynapse
inferred from experiment
(Götz et al., 2021)
located_in presynaptic active zone
inferred from experiment
(Götz et al., 2021)
located_in vesicle
inferred from experiment
(Götz et al., 2021)
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Rab family. (O18333)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
GTPase activity
RHEA 19669:
Summaries
Gene Snapshot
Rab2 (Rab2) encodes a protein that belongs to the Rab family of small Ras-like GTPases that regulate vesicle trafficking. Rab2 product contributes to the maturation and fusion of endosomes and autophagosomes with lysosomes. [Date last reviewed: 2018-09-13]
Gene Group (FlyBase)
RAB GTPASES -
The Rab family are members of the Ras superfamily of small GTPases. Rabs regulate vesicle trafficking including cargo selection, vesicle budding, transport, docking and targeting. They localize to different intracellular compartments directed by specific isoprenylation of C-terminal motifs. (Adapted from PMID:15731001).
Protein Function (UniProtKB)
May be involved in bidirectional endoplasmic reticulum (ER) to Golgi trafficking (PubMed:33822845). Together with Rab7 involved in promoting fusion of autophagosomes and endosomes with lysosomes, probably through recruitment of the HOPS tethering complex (PubMed:28063257, PubMed:28483915, PubMed:31194677, PubMed:33822845). Involved in biosynthetic transport to lysosomes (PubMed:28483915). In larval motor neurons, mediates the biogenesis of presynaptic cargo vesicles and their long-range axonal trafficking to synaptic termini (PubMed:33822845). Not involved in axonal trafficking of mitochondria (PubMed:33822845). During vesicle biogenesis, active zone proteins (including brp/Bruchpilot) and synaptic vesicle proteins (including VGlut) are sorted from the trans-Golgi in a Rab2-dependent manner via, at least, two independent routes (PubMed:33822845). Acts upstream of Arl8 during presynaptic precursor vesicle biogenesis (PubMed:33822845). Associated with lysosomal marker positive presynaptic cargo vesicles during anterograde and retrograde axonal trafficking, probably while in its GTP-bound active state (PubMed:33822845). Involved in the delivery of presynaptic cargos, but not presynapse assembly or active zone function at synaptic termini (PubMed:33822845). Required for autophagocytosis-dependent remodeling of myofibrils and transverse-tubules (T-tubules) during metamorphosis (PubMed:28063257).
(UniProt, O18333)
Summary (Interactive Fly)

Rab family GTPase - autophagic clearance - endocytic lysosomal degradation - regulation of neuromuscular junction organization through the Rab2 effector ICA69

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Rab2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O18333)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Rab2-RA
FBtr0086124
NM_057742
1712
213
Rab2-RB
FBtr0336658
NM_001273803
1087
213
Additional Transcript Data and Comments
Reported size (kB)

2.1 (longest cDNA)

(Satoh et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Rab2-PA
FBpp0085458
23.6
213
6.36
O18333
NP_477090
AAM70817
Rab2-PB
FBpp0307641
23.6
213
6.36
O18333
NP_001260732
AGB93265
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

213 aa isoforms: Rab2-PA, Rab2-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

201 (aa)

(Sasamura et al., 1997)

213 (aa)

(Satoh et al., 1997)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts (GTP-bound form) with Vps16A and Vps39; the interaction with Vps39 is probably direct.

(UniProt, O18333)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rab2 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.24

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
larval labral sensory complex
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Sasamura et al., 1997)
embryonic stage -- adult stage
(Sasamura et al., 1997)
embryonic stage 14 -- 15
presumptive embryonic/larval central nervous system
(Sasamura et al., 1997)
presumptive embryonic/larval peripheral nervous system
(Sasamura et al., 1997)
Additional Descriptive Data

Rab2 transcript is detected in all developmental stages. Using in situ hybridization, Rab2 is detected in all embryonic tissues, but is at highest levels in the central and peripheral nervous systems of stage 14-15 embryos.

(Sasamura et al., 1997)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in autolysosome membrane
inferred from direct assay
(Lőrincz et al., 2017)
located_in autophagosome membrane
inferred from direct assay
(Fujita et al., 2017, Lőrincz et al., 2017)
located_in endoplasmic reticulum exit site
inferred from direct assay
(Ke et al., 2018)
located_in Golgi apparatus
inferred from direct assay
(Gillingham et al., 2014)
located_in neuronal cell body
inferred from high throughput direct assay
(Chan et al., 2011)
located_in plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
located_in postsynapse of neuromuscular junction
inferred from direct assay
(Mallik et al., 2017)
located_in type II terminal bouton
inferred from direct assay
(Mallik et al., 2017)
Expression Deduced from Reporters
Reporter: P{Rab2.HA}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
organism | ubiquitous
(Lund et al., 2018)
imaginal disc

Comment: enriched

(Lund et al., 2018)
larval central nervous system

Comment: enriched

(Lund et al., 2018)
Reporter: PBac{I-SceI(FRT.Rab2-GAL4.ATG(loxP.3xP3-RFP))}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
neuropil glial sheath
(Jin et al., 2012)
Bolwig organ | restricted
(Jin et al., 2012)
embryonic/larval mushroom body
(Jin et al., 2012)
eye disc | restricted
(Jin et al., 2012, Chan et al., 2011)
embryonic/larval optic stalk surface glial cell | intense
(Jin et al., 2012)
leg disc | restricted
(Jin et al., 2012, Chan et al., 2011)
wing disc | restricted
(Jin et al., 2012, Chan et al., 2011)
embryonic/larval salivary gland | restricted
(Jin et al., 2012, Chan et al., 2011)
neuron of larval brain
(Chan et al., 2011)
glial cell | subset of larval brain
(Chan et al., 2011)
neuron | subset of larval ventral nerve cord
(Chan et al., 2011)
pupal stage P6 -- P7
neuropil glial sheath

Comment: 30-40h APF

(Jin et al., 2012)
glial cell of second optic chiasma | intense

Comment: 30-40h APF

(Jin et al., 2012)
neuron of adult optic lobe

Comment: 30-40h APF

(Jin et al., 2012)
mushroom body | faint

Comment: 30-40h APF

(Jin et al., 2012)
eye photoreceptor cell

Comment: 30-40h APF

(Jin et al., 2012)
neuron of pupal brain

Comment: 30-40h APF

(Chan et al., 2011)
mushroom body

Comment: 30-40h APF

(Chan et al., 2011)
adult stage
adult ensheathing glial cell
(Jin et al., 2012)
adult inner optic chiasma giant glial cell
(Jin et al., 2012)
neuron of adult optic lobe | faint
(Jin et al., 2012)
adult mushroom body | intense
(Jin et al., 2012, Chan et al., 2011)
adult antennal lobe | intense
(Jin et al., 2012)
adult insulin secreting cell of pars intercerebralis
(Jin et al., 2012)
neuron of lamina | intense
(Jin et al., 2012)
ellipsoid body
(Jin et al., 2012)
fan-shaped body
(Jin et al., 2012)
neuron of adult brain
(Chan et al., 2011)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Rab2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 24 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rab2
Transgenic constructs containing regulatory region of Rab2
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal | recessive
lethal - all die before end of larval stage
lethal - all die before end of P-stage (with Df(2R)BSC326)
lethal - all die before end of P-stage | recessive
partially lethal, with Scer\GAL4CCAP.PP
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile, with Scer\GAL4elav.PLu
Other Phenotypes
Allele
abnormal eye color | adult stage, with Scer\GAL4GMR.PF
abnormal flight, with Scer\GAL4Mef2.PR
abnormal immune response | adult stage, with Scer\GAL4Hml.Δ
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4Act5C.PU
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4Mef2.PU
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
abnormal size | third instar larval stage
abnormal starvation stress response | somatic clone | third instar larval stage, with Scer\GAL4Act.PU
abnormal starvation stress response | third instar larval stage
decreased rate of adult locomotory behavior, with Scer\GAL4Ddc.PL
increased rate of adult locomotory behavior | progressive, with Scer\GAL4Ddc.PL
increased size | larval stage
long lived, with Scer\GAL4Ddc.PL
short lived, with Rab2UAS.mCherry, Scer\GAL4RapGAP1-OK6
short lived, with Rab2Δ1, Scer\GAL4RapGAP1-OK6
short lived, with Scer\GAL4Ddc.PL
some die during larval stage
some die during larval stage (with Df(2R)BSC326)
some die during pharate adult stage
some die during pharate adult stage (with Df(2R)BSC326)
some die during pupal stage
some die during pupal stage (with Df(2R)BSC326)
visible | adult stage, with Scer\GAL4386Y
visible | adult stage, with Scer\GAL4Burs.PP
visible | adult stage, with Scer\GAL4CCAP.PP
visible | adult stage, with Scer\GAL4dimm-929
visible | adult stage, with Scer\GAL4GMR.PF
Phenotype manifest in
Allele
autolysosome | larval stage
autolysosome | larval stage | somatic clone, with Scer\GAL4Act.PU
autophagosome | larval stage
autophagosome | larval stage | somatic clone, with Scer\GAL4Act.PU
autophagosome | third instar larval stage
cis-Golgi network | third instar larval stage, with Scer\GAL4Cg.PA
dense core granule | larval stage
embryonic/larval fat body | larval stage
embryonic/larval fat body | larval stage | somatic clone, with Scer\GAL4Act.PU
embryonic/larval fat body | third instar larval stage
embryonic/larval fat body | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
embryonic/larval garland cell | third instar larval stage
embryonic/larval midgut cell | larval stage | somatic clone, with Scer\GAL4Act.PU
embryonic/larval neuromuscular junction | larval stage
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Act5C.PU
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Mef2.PU
embryonic/larval salivary gland | third instar larval stage
endosome | third instar larval stage
extracellular matrix | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
eye, with Scer\GAL4GMR.PF
hemocyte | adult stage, with Scer\GAL4Hml.Δ
larval brain | third instar larval stage
larval pericardial cell | larval stage
larval peripheral nervous system | larval stage
late endosome | larval stage
late endosome | third instar larval stage
lysosome | larval stage
lysosome | larval stage | somatic clone, with Scer\GAL4Act.PU
lysosome | third instar larval stage
NMJ bouton | third instar larval stage, with Scer\GAL4Act5C.PU
NMJ bouton | third instar larval stage, with Scer\GAL4Mef2.PU
phagocytic vesicle, with Scer\GAL4Hml.Δ
retinal pigment granule | adult stage, with Scer\GAL4GMR.PF
wing, with Scer\GAL4386Y
wing, with Scer\GAL4Burs.PP
wing, with Scer\GAL4CCAP.PP
wing, with Scer\GAL4dimm-929
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (61)
Hsap\RAB2A
13 of 14
Yes
Yes
1  
Hsap\RAB2B
10 of 14
No
Yes
Hsap\DNAJC27
2 of 14
No
Yes
Hsap\IFT27
1 of 14
No
No
Hsap\RAB1A
1 of 14
No
No
Hsap\RAB1B
1 of 14
No
No
Hsap\RAB1C
1 of 14
No
No
Hsap\RAB3A
1 of 14
No
No
Hsap\RAB3B
1 of 14
No
No
Hsap\RAB3C
1 of 14
No
No
Hsap\RAB3D
1 of 14
No
No
Hsap\RAB4A
1 of 14
No
No
Hsap\RAB4B
1 of 14
No
No
Hsap\RAB5A
1 of 14
No
No
1  
Hsap\RAB5B
1 of 14
No
No
Hsap\RAB5C
1 of 14
No
No
1  
Hsap\RAB6A
1 of 14
No
No
Hsap\RAB6B
1 of 14
No
No
Hsap\RAB6C
1 of 14
No
No
Hsap\RAB6D
1 of 14
No
No
Hsap\RAB7A
1 of 14
No
No
5  
Hsap\RAB7B
1 of 14
No
No
Hsap\RAB8A
1 of 14
No
No
1  
Hsap\RAB8B
1 of 14
No
No
Hsap\RAB9A
1 of 14
No
No
1  
Hsap\RAB9B
1 of 14
No
No
1  
Hsap\RAB10
1 of 14
No
No
1  
Hsap\RAB11A
1 of 14
No
No
Hsap\RAB11B
1 of 14
No
No
1  
Hsap\RAB12
1 of 14
No
No
Hsap\RAB13
1 of 14
No
No
Hsap\RAB14
1 of 14
No
No
1  
Hsap\RAB15
1 of 14
No
No
Hsap\RAB17
1 of 14
No
No
Hsap\RAB18
1 of 14
No
No
1  
Hsap\RAB19
1 of 14
No
No
Hsap\RAB21
1 of 14
No
No
Hsap\RAB22A
1 of 14
No
No
Hsap\RAB25
1 of 14
No
No
Hsap\RAB26
1 of 14
No
No
Hsap\RAB27A
1 of 14
No
No
1  
Hsap\RAB27B
1 of 14
No
No
1  
Hsap\RAB30
1 of 14
No
No
1  
Hsap\RAB31
1 of 14
No
No
Hsap\RAB33A
1 of 14
No
No
Hsap\RAB33B
1 of 14
No
No
Hsap\RAB35
1 of 14
No
No
Hsap\RAB37
1 of 14
No
No
Hsap\RAB39A
1 of 14
No
No
1  
Hsap\RAB39B
1 of 14
No
No
4  
Hsap\RAB41
1 of 14
No
No
1  
Hsap\RAB42
1 of 14
No
No
Hsap\RAB43
1 of 14
No
No
1  
Hsap\RASL11A
1 of 14
No
No
1  
Hsap\RASL11B
1 of 14
No
No
1  
Hsap\RASL12
1 of 14
No
No
Hsap\RERG
1 of 14
No
No
Hsap\RERGL
1 of 14
No
No
Hsap\RHEB
1 of 14
No
No
1  
Hsap\RHEBL1
1 of 14
No
No
Hsap\RIT1
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (36)
Rnor\Rab2a
13 of 14
Yes
Yes
Rnor\Rab2b
10 of 14
No
Yes
Rnor\Dnajc27
2 of 14
No
Yes
Rnor\Ift27
1 of 14
No
No
Rnor\Rab1a
1 of 14
No
No
Rnor\Rab1b
1 of 14
No
No
Rnor\Rab3b
1 of 14
No
No
Rnor\Rab4a
1 of 14
No
No
Rnor\Rab4b
1 of 14
No
No
Rnor\Rab5b
1 of 14
No
No
Rnor\Rab8a
1 of 14
No
No
Rnor\Rab8b
1 of 14
No
No
Rnor\Rab11a
1 of 14
No
No
Rnor\Rab11b
1 of 14
No
No
Rnor\Rab13
1 of 14
No
No
Rnor\Rab14
1 of 14
No
No
Rnor\Rab15
1 of 14
No
No
Rnor\Rab18
1 of 14
No
No
Rnor\Rab19
1 of 14
No
No
Rnor\Rab21
1 of 14
No
No
Rnor\Rab25
1 of 14
No
No
Rnor\Rab26
1 of 14
No
No
Rnor\Rab30
1 of 14
No
No
Rnor\Rab33a
1 of 14
No
No
Rnor\Rab33b
1 of 14
No
No
Rnor\Rab35
1 of 14
No
No
Rnor\Rab37
1 of 14
No
No
Rnor\Rab39a
1 of 14
No
No
Rnor\Rab42
1 of 14
No
No
Rnor\Rab43
1 of 14
No
No
Rnor\Rasl11a
1 of 14
No
No
Rnor\Rasl11b
1 of 14
No
No
Rnor\Rasl12
1 of 14
No
No
Rnor\Rergl
1 of 14
No
No
Rnor\Rerg
1 of 14
No
No
Rnor\Rhebl1
1 of 14
No
No
Mus musculus (laboratory mouse) (41)
Mmus\Rab2a
12 of 14
Yes
Yes
Mmus\Rab2b
10 of 14
No
Yes
Mmus\Dnajc27
2 of 14
No
Yes
Mmus\Ift27
1 of 14
No
No
Mmus\Rab1a
1 of 14
No
No
1  
Mmus\Rab1b
1 of 14
No
No
Mmus\Rab3b
1 of 14
No
No
Mmus\Rab3d
1 of 14
No
No
Mmus\Rab4a
1 of 14
No
No
Mmus\Rab4b
1 of 14
No
No
Mmus\Rab5b
1 of 14
No
No
Mmus\Rab8a
1 of 14
No
No
Mmus\Rab8b
1 of 14
No
No
Mmus\Rab9
1 of 14
No
No
Mmus\Rab10
1 of 14
No
No
Mmus\Rab11a
1 of 14
No
No
Mmus\Rab11b
1 of 14
No
No
Mmus\Rab13
1 of 14
No
No
Mmus\Rab14
1 of 14
No
No
Mmus\Rab15
1 of 14
No
No
Mmus\Rab18
1 of 14
No
No
Mmus\Rab19
1 of 14
No
No
Mmus\Rab21
1 of 14
No
No
Mmus\Rab25
1 of 14
No
No
Mmus\Rab26
1 of 14
No
No
Mmus\Rab30
1 of 14
No
No
Mmus\Rab33a
1 of 14
No
No
Mmus\Rab33b
1 of 14
No
No
Mmus\Rab35
1 of 14
No
No
Mmus\Rab37
1 of 14
No
No
Mmus\Rab39b
1 of 14
No
No
Mmus\Rab39
1 of 14
No
No
Mmus\Rab42
1 of 14
No
No
Mmus\Rab43
1 of 14
No
No
Mmus\Rasl11a
1 of 14
No
No
Mmus\Rasl11b
1 of 14
No
No
Mmus\Rasl12
1 of 14
No
No
Mmus\Rergl
1 of 14
No
No
Mmus\Rerg
1 of 14
No
No
Mmus\Rhebl1
1 of 14
No
No
Mmus\Rit1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (30)
Xtro\rab2a
9 of 13
Yes
Yes
Xtro\rab2b
8 of 13
No
Yes
Xtro\dnajc27
1 of 13
No
No
Xtro\ift27
1 of 13
No
Yes
Xtro\LOC100488596
1 of 13
No
No
Xtro\rab1a
1 of 13
No
No
Xtro\rab3a
1 of 13
No
No
Xtro\rab3b
1 of 13
No
No
Xtro\rab3c
1 of 13
No
No
Xtro\rab3d
1 of 13
No
No
Xtro\rab4b
1 of 13
No
No
Xtro\rab5b
1 of 13
No
No
Xtro\rab5d
1 of 13
No
No
Xtro\rab6b
1 of 13
No
No
Xtro\rab8b
1 of 13
No
No
Xtro\rab11b.1
1 of 13
No
No
Xtro\rab11b.2
1 of 13
No
No
Xtro\rab12
1 of 13
No
No
Xtro\rab18
1 of 13
No
No
Xtro\rab19
1 of 13
No
No
Xtro\rab26
1 of 13
No
No
Xtro\rab33a
1 of 13
No
Yes
Xtro\rab35l
1 of 13
No
No
Xtro\rab35
1 of 13
No
No
Xtro\rab39a
1 of 13
No
No
Xtro\rab39b
1 of 13
No
No
Xtro\rasl11b
1 of 13
No
No
Xtro\rergl
1 of 13
No
No
Xtro\rerg
1 of 13
No
No
Xtro\uchl5
1 of 13
No
No
Danio rerio (Zebrafish) (59)
Drer\rab2a
13 of 14
Yes
Yes
Drer\dnajc27
2 of 14
No
Yes
Drer\dnajb12b
1 of 14
No
No
Drer\ift27
1 of 14
No
Yes
Drer\LOC555645
1 of 14
No
No
Drer\LOC100330257
1 of 14
No
No
Drer\LOC101885697
1 of 14
No
No
Drer\rab1aa
1 of 14
No
No
Drer\rab1ab
1 of 14
No
No
Drer\rab1ba
1 of 14
No
No
Drer\rab1bb
1 of 14
No
No
Drer\rab3c
1 of 14
No
No
Drer\rab4a
1 of 14
No
No
Drer\rab4b
1 of 14
No
No
Drer\rab5b
1 of 14
No
No
Drer\rab7a
1 of 14
No
No
Drer\rab8a
1 of 14
No
No
Drer\rab8b
1 of 14
No
No
Drer\rab10
1 of 14
No
No
Drer\rab11a
1 of 14
No
No
Drer\rab11al
1 of 14
No
No
Drer\rab11ba
1 of 14
No
No
Drer\rab11bb
1 of 14
No
No
Drer\rab13
1 of 14
No
No
Drer\rab14
1 of 14
No
No
Drer\rab14l
1 of 14
No
No
Drer\rab18a
1 of 14
No
No
Drer\rab18b
1 of 14
No
No
Drer\rab21
1 of 14
No
No
Drer\rab22a
1 of 14
No
No
Drer\rab25a
1 of 14
No
No
Drer\rab25b
1 of 14
No
No
Drer\rab30
1 of 14
No
No
Drer\rab33ba
1 of 14
No
No
Drer\rab35a
1 of 14
No
No
Drer\rab35b
1 of 14
No
No
Drer\rab39ba
1 of 14
No
No
Drer\rab39bb
1 of 14
No
No
Drer\rab42a
1 of 14
No
No
Drer\rab42b
1 of 14
No
No
Drer\rab43
1 of 14
No
No
Drer\rasl11a
1 of 14
No
No
Drer\rasl11b
1 of 14
No
No
Drer\rasl12
1 of 14
No
No
Drer\rerg
1 of 14
No
No
Drer\rergla
1 of 14
No
No
Drer\rerglb
1 of 14
No
No
Drer\rhebl1
1 of 14
No
No
Drer\rit1
1 of 14
No
No
Drer\si:dkey-16l2.16
1 of 14
No
No
Drer\si:dkey-34d22.2
1 of 14
No
No
Drer\si:dkey-34d22.5
1 of 14
No
No
Drer\si:dkeyp-59c12.1
1 of 14
No
No
Drer\zgc:64022
1 of 14
No
No
Drer\zgc:100918
1 of 14
No
No
Drer\zgc:101559
1 of 14
No
No
Drer\zgc:110699
1 of 14
No
No
Drer\zgc:171704
1 of 14
No
No
Drer\zgc:171927
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (24)
Cele\unc-108
14 of 14
Yes
Yes
Cele\F11A5.3
5 of 14
No
Yes
Cele\F11A5.4
5 of 14
No
Yes
Cele\aex-6
1 of 14
No
No
Cele\rab-1
1 of 14
No
No
Cele\rab-3
1 of 14
No
No
Cele\rab-5
1 of 14
No
No
Cele\rab-6.1
1 of 14
No
No
Cele\rab-6.2
1 of 14
No
No
Cele\rab-7
1 of 14
No
No
Cele\rab-8
1 of 14
No
No
Cele\rab-10
1 of 14
No
No
Cele\rab-11.1
1 of 14
No
No
Cele\rab-11.2
1 of 14
No
No
Cele\rab-14
1 of 14
No
No
Cele\rab-18
1 of 14
No
No
Cele\rab-19
1 of 14
No
No
Cele\rab-21
1 of 14
No
No
Cele\rab-30
1 of 14
No
No
Cele\rab-35
1 of 14
No
No
Cele\rab-37
1 of 14
No
No
Cele\rab-39
1 of 14
No
No
Cele\rap-1
1 of 14
No
No
Cele\ras-2
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (24)
Agam\AgaP_AGAP005393
12 of 12
Yes
Yes
Agam\AgaP_AGAP004204
2 of 12
No
No
Agam\AgaP_AGAP008419
2 of 12
No
No
Agam\AgaP_AGAP009325
2 of 12
No
No
Agam\AgaP_AGAP000433
1 of 12
No
No
Agam\AgaP_AGAP000671
1 of 12
No
No
Agam\AgaP_AGAP001211
1 of 12
No
No
Agam\AgaP_AGAP001617
1 of 12
No
No
Agam\AgaP_AGAP001874
1 of 12
No
No
Agam\AgaP_AGAP002092
1 of 12
No
No
Agam\AgaP_AGAP003028
1 of 12
No
No
Agam\AgaP_AGAP003577
1 of 12
No
No
Agam\AgaP_AGAP004146
1 of 12
No
No
Agam\AgaP_AGAP004559
1 of 12
No
No
Agam\AgaP_AGAP005255
1 of 12
No
No
Agam\AgaP_AGAP006025
1 of 12
No
No
Agam\AgaP_AGAP006873
1 of 12
No
No
Agam\AgaP_AGAP007096
1 of 12
No
No
Agam\AgaP_AGAP007901
1 of 12
No
No
Agam\AgaP_AGAP008224
1 of 12
No
No
Agam\AgaP_AGAP008989
1 of 12
No
No
Agam\AgaP_AGAP009846
1 of 12
No
No
Agam\AgaP_AGAP010875
1 of 12
No
No
Agam\AgaP_AGAP011363
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (60)
Atha\GB2
11 of 13
Yes
Yes
Atha\RABB1C
11 of 13
Yes
Yes
Atha\RABB1a
8 of 13
No
Yes
Atha\ARA-2
1 of 13
No
No
Atha\ARA4
1 of 13
No
No
Atha\ARA6
1 of 13
No
No
Atha\ARA7
1 of 13
No
No
Atha\ArRABA1h
1 of 13
No
No
Atha\AT4G03156
1 of 13
No
No
Atha\AT4G08190
1 of 13
No
No
Atha\AT5G46025
1 of 13
No
No
Atha\AT5G59840
1 of 13
No
No
Atha\ATFP8
1 of 13
No
No
Atha\RA-5
1 of 13
No
No
Atha\RAB1A
1 of 13
No
No
Atha\RAB1C
1 of 13
No
No
Atha\RAB6A
1 of 13
No
No
Atha\RAB7A
1 of 13
No
No
Atha\RAB7B
1 of 13
No
No
Atha\RAB8
1 of 13
No
No
Atha\RAB8C
1 of 13
No
No
Atha\RAB11c
1 of 13
No
No
Atha\RAB18
1 of 13
No
No
Atha\RABA1b
1 of 13
No
No
Atha\RABA1c
1 of 13
No
No
Atha\RABA1d
1 of 13
No
No
Atha\RABA1e
1 of 13
No
No
Atha\RABA1f
1 of 13
No
No
Atha\RABA1g
1 of 13
No
No
Atha\RABA1i
1 of 13
No
No
Atha\RABA2b
1 of 13
No
No
Atha\RABA2c
1 of 13
No
No
Atha\RABA2D
1 of 13
No
No
Atha\RABA3
1 of 13
No
No
Atha\RABA4a
1 of 13
No
No
Atha\RABA4B
1 of 13
No
No
Atha\RABA4C
1 of 13
No
No
Atha\RABA4D
1 of 13
No
No
Atha\RABA4E
1 of 13
No
No
Atha\RABA5a
1 of 13
No
No
Atha\RABA5b
1 of 13
No
No
Atha\RABA5d
1 of 13
No
No
Atha\RABA5E
1 of 13
No
No
Atha\RABA6a
1 of 13
No
No
Atha\RABA6b
1 of 13
No
No
Atha\RABC2A
1 of 13
No
No
Atha\RABC2b
1 of 13
No
No
Atha\RABE1c
1 of 13
No
No
Atha\RABE1e
1 of 13
No
No
Atha\RABG1
1 of 13
No
No
Atha\RABG3A
1 of 13
No
No
Atha\RABG3B
1 of 13
No
No
Atha\RABG3c
1 of 13
No
No
Atha\RABG3d
1 of 13
No
No
Atha\RABG3E
1 of 13
No
No
Atha\RABH1a
1 of 13
No
No
Atha\RABH1c
1 of 13
No
No
Atha\RABH1d
1 of 13
No
No
Atha\RABH1e
1 of 13
No
No
Atha\RHA1
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (7)
Scer\SEC4
1 of 13
Yes
No
Scer\VPS21
1 of 13
Yes
No
Scer\YPT1
1 of 13
Yes
No
Scer\YPT6
1 of 13
Yes
No
Scer\YPT7
1 of 13
Yes
No
Scer\YPT31
1 of 13
Yes
No
Scer\YPT32
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (6)
Spom\ypt4
3 of 12
Yes
No
Spom\rhb1
1 of 12
No
No
Spom\ryh1
1 of 12
No
No
Spom\ypt1
1 of 12
No
No
Spom\ypt2
1 of 12
No
No
Spom\ypt3
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Rab2. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (35)
Rab4
6 of 13
Rab14
5 of 13
Rab11
3 of 13
Rab39
3 of 13
Rab1
2 of 13
Rab3
2 of 13
Rab5
2 of 13
Rab6
2 of 13
Rab7
2 of 13
Rab8
2 of 13
Rab9Fb
2 of 13
Rab9
2 of 13
Rab10
2 of 13
Rab18
2 of 13
Rab19
2 of 13
Rab21
2 of 13
Rab26
2 of 13
Rab27
2 of 13
Rab30
2 of 13
Rab35
2 of 13
RabX6
2 of 13
CG4789
1 of 13
CG5160
1 of 13
CG8519
1 of 13
Rab9Db
1 of 13
Rab9D
1 of 13
Rab9E
1 of 13
Rab9Fa
1 of 13
Rab23
1 of 13
Rab32
1 of 13
RabX1
1 of 13
RabX2
1 of 13
RabX4
1 of 13
RabX5
1 of 13
Rap1
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Rab2Q65L.UASp.YFP
    ameliorates  Parkinson's disease 1
    modeled by Hsap\SNCAA53T.UAS
    (Szinyákovics et al., 2023)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RAB2A; RAB2A, member RAS oncogene family
    13 of 14
    179509
         
        RAB2B; RAB2B, member RAS oncogene family
        10 of 14
        607466
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            Rab2 - ATPsynγ
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Arf1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Arl8
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - BicD
            pull down, anti tag western blot, peptide massfingerprinting
            (Gillingham et al., 2014, Gillingham et al., 2014, Gillingham et al., 2014)
            Rab2 - CCT3
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - CCT6
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - CG12702
            pull down, peptide massfingerprinting
            (Gillingham et al., 2014)
            Rab2 - CG1416
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - CG17598
            pull down, peptide massfingerprinting
            (Gillingham et al., 2014, Gillingham et al., 2014)
            Rab2 - CG32485
            pull down, anti tag western blot, peptide massfingerprinting, two hybrid
            (Gillingham et al., 2014, Gillingham et al., 2014)
            Rab2 - CG5439
            pull down, peptide massfingerprinting
            (Gillingham et al., 2014)
            Rab2 - CG5854
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - CG9356
            pull down, peptide massfingerprinting
            (Gillingham et al., 2014)
            Rab2 - Echs1
            pull down, peptide massfingerprinting
            (Gillingham et al., 2014)
            Rab2 - FASN1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Fam114A
            pull down, peptide massfingerprinting, anti tag western blot, two hybrid
            (Gillingham et al., 2014, Gillingham et al., 2014)
            Rab2 - GCC185
            pull down, peptide massfingerprinting, two hybrid, western blot
            (Gillingham et al., 2014, Torres et al., 2014, Sinka et al., 2008)
            Rab2 - GCC88
            pull down, western blot
            (Sinka et al., 2008)
            Rab2 - Gale
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Gmap
            pull down, western blot, peptide massfingerprinting, two hybrid
            (Gillingham et al., 2014, Sinka et al., 2008)
            Rab2 - Golgin104
            pull down, anti tag western blot, two hybrid, peptide massfingerprinting
            (Gillingham et al., 2014, Gillingham et al., 2014, Gillingham et al., 2014)
            Rab2 - Golgin245
            pull down, western blot, two hybrid
            (Sinka et al., 2008)
            Rab2 - Gp93
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Grip84
            pull down, peptide massfingerprinting
            (Gillingham et al., 2014)
            Rab2 - Grip91
            pull down, peptide massfingerprinting
            (Gillingham et al., 2014)
            Rab2 - Hel25E
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Hsl
            pull down, peptide massfingerprinting
            (Gillingham et al., 2014)
            Rab2 - KdelR
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Ldh
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Mcad
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Mec2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Msp300
            pull down, peptide massfingerprinting
            (Gillingham et al., 2014)
            Rab2 - Ost1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Ost48
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Rab1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Rab11
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Rab5
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Rab6
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Rab7
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Rdh1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - SERCA
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - ScsβA
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - ScsβG
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - SsRβ
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Tapδ
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Tecr
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - UQCR-C2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - Vps11
            pull down, peptide massfingerprinting
            (Gillingham et al., 2014, Gillingham et al., 2014)
            Rab2 - Vps13B
            pull down, peptide massfingerprinting
            (Gillingham et al., 2014)
            Rab2 - Vps16A
            anti tag coimmunoprecipitation, western blot, pull down, peptide massfingerprinting
            (Lőrincz et al., 2017, Gillingham et al., 2014)
            Rab2 - Vps39
            pull down, anti tag western blot, peptide massfingerprinting, western blot, two hybrid
            (Lőrincz et al., 2017, Gillingham et al., 2014, Gillingham et al., 2014, Gillingham et al., 2014)
            Rab2 - car
            pull down, peptide massfingerprinting
            (Gillingham et al., 2014)
            Rab2 - dor
            pull down, peptide massfingerprinting
            (Gillingham et al., 2014)
            Rab2 - fax
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - lt
            pull down, peptide massfingerprinting
            (Gillingham et al., 2014)
            Rab2 - mt:CoII
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - mv
            pull down, peptide massfingerprinting
            (Gillingham et al., 2014, Gillingham et al., 2014)
            Rab2 - p115
            pull down, peptide massfingerprinting
            (Gillingham et al., 2014, Gillingham et al., 2014)
            Rab2 - porin
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - spidey
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - unc-104
            proximity-dependent biotin identification, western blot
            (Lund et al., 2021)
            Rab2 - wal
            experimental knowledge based
            (Guruharsha et al., 2011)
            Rab2 - γTub23C
            pull down, peptide massfingerprinting
            (Gillingham et al., 2014)
            Summary of Genetic Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Rab2
            suppressible
            ICA69
            (Mallik et al., 2017)
            Rab2
            suppressible
            Rab7
            (Lőrincz et al., 2017)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Mitf
            suppressible
            Rab2
            (Zhang et al., 2015)
            External Data
            Subunit Structure (UniProtKB)
            Interacts (GTP-bound form) with Vps16A and Vps39; the interaction with Vps39 is probably direct.
            (UniProt, O18333 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2R
            Recombination map
            2-55
            Cytogenetic map
            42C5-42C5
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            42C5-42C5
            Limits computationally determined from genome sequence between P{lacW}geminink14019&P{PZ}Adf101349 and P{lacW}ublk03203&P{PZ}CG328709967
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            42C-42C
            (Ozaki, 1996.4.3)
            42C-42C
            (determined by in situ hybridisation)
            (Sasamura et al., 1997, Satoh et al., 1997, Sasamura, 1995)
            Experimentally Determined Recombination Data
            Location

            2-55

            (FlyBase, 2016)

            2-56.0

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (21)
            Genomic Clones (20)
            cDNA Clones (105)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                dsRNA has been made from templates generated with primers directed against this gene.

                (Kouranti et al., 2006)

                Identified in an RNAi screen for host factors that alter infection of SL2 cells by L.monocytogenes.

                (Agaisse et al., 2005)

                Area matching Drosophila rab2 gene (inverted), Acc. No. D84313.

                (Davies, 2001.3.15)

                Isolated from a Drosophila head cDNA library.

                (Satoh et al., 1997)

                Identification: Sequence similarity to Rab3.

                (Sasamura et al., 1995)
                Relationship to Other Genes
                Source for database merge of
                Additional comments
                Nomenclature History
                Source for database identify of
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (9)
                Reported As
                Symbol Synonym
                CG3269
                (Laffafian and Tepass, 2019, Kolkhof et al., 2017, Dunst et al., 2015, Christis and Munro, 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009, Sinka et al., 2008, Zhang et al., 2007, Colicelli, 2004, Verstreken and Bellen, 2000.9.4)
                DRAB2
                (Kohno et al., 1994)
                DRab2
                (Satoh et al., 1997)
                DmRab2
                (Pereira-Leal and Seabra, 2001, Pereira-Leal and Seabra, 2001)
                Drab2
                (Sasamura, 1999.11.29, Sasamura et al., 1997, Sasamura et al., 1995)
                O18333
                (Rojas et al., 2012)
                Rab2
                (Zhang et al., 2025, Kim et al., 2024, Vicidomini et al., 2024, Szinyákovics et al., 2023, Zhou et al., 2023, Götz et al., 2021, Kohrs et al., 2021, Lund et al., 2021, Ma and Brill, 2021, Ricolo et al., 2021, Csizmadia and Juhász, 2020, Gohel et al., 2020, Boda et al., 2019, Hodgson et al., 2019, Krämer et al., 2019, Laffafian and Tepass, 2019, Csizmadia et al., 2018, Gene Disruption Project members, 2018-, Lund et al., 2018, Coutinho-Budd et al., 2017, Fujita et al., 2017, Lőrincz et al., 2017, Mallik et al., 2017, Transgenic RNAi Project members, 2017-, Caviglia et al., 2016, Meehan et al., 2016, Lardong et al., 2015, White et al., 2015, Zhang et al., 2015, Bussell et al., 2014, Garg and Wu, 2014, Gillingham et al., 2014, Gillingham et al., 2014, Gillingham et al., 2014, Torres et al., 2014, Chow et al., 2013, Kwon et al., 2013, Thomae et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Wang et al., 2012, Schulte et al., 2010, Yuan et al., 2010, Tan et al., 2009, Thomas et al., 2009, Kim et al., 2008, Morrison et al., 2008, Sinka et al., 2008, Bakal et al., 2007, Buszczak et al., 2007, Curtis et al., 2007, Zhang et al., 2007, Zhang et al., 2007, Kouranti et al., 2006)
                rab2
                (Lőrincz et al., 2019, Lammers et al., 2017, Lőrincz et al., 2017, Jin et al., 2012, Chan et al., 2011, Mudiganti et al., 2010, Bellen, 2000.12.25, Ozaki, 1996.4.3)
                Name Synonyms
                Rab-protein 2
                (Cammarato et al., 2011)
                Rab2
                Secondary FlyBase IDs
                  Datasets (1)
                  Study focus (1)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  • bait_protein
                  Rab_Effectors_interaction_map
                  Interaction map generated by purification of most Rab factors, with identification of copurifying effectors by mass spectrometry.
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 50 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  FlyMine - An integrated database for Drosophila genomics
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  PDB - An information portal to biological macromolecular structures
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  References (140)