tissue polarity, an essential component of the contractile process that functions as a membrane ratchet to ensure unidirectional movement of intercalating cells - gastrulation - mesoderm invagination - Whacked and Rab35 polarize dynein-motor-complex-dependent seamless tube growth during tracheal development - Skywalker facilitates endosomal trafficking of synaptic vesicles at NMJ boutons by controlling Rab35 activity
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rab35 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Rab35 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
A large increase in the proportion of binucleated cells is seen following transfection of S2 cells with dsRNA made from templates generated with primers directed against this gene.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
dsRNA made from templates generated with primers directed against Rab35 that is transfected into S2 treated with Listeria monocytogenes reveals Rab35 to be involved in Listeria monocytogenes entry, intracellular growth, and vacuolar escape.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: binucleate cells.