FlyBase Gene Report: Dmel\Rgk1

General Information

Symbol

Dmel\Rgk1

Species

D. melanogaster

Name

Rad, Gem/Kir family member 1

Annotation Symbol

CG44011

Feature Type

protein_coding_gene

FlyBase ID

FBgn0264753

Gene Model Status

Current

Stock Availability

15 publicly available

Gene Summary

Rad, Gem/Kir family member 1 (Rgk1) encodes a small GTPase involved in anesthesia-resistant and medium-term memory. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

56C10-56D1

Sequence location

2R:19,311,148..19,356,525 [-]

Recombination map

2-89

RefSeq locus

NT_033778 REGION:19311148..19356525

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables calcium channel regulator activity

inferred from direct assay

(Puhl et al., 2014)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables calcium channel regulator activity

inferred from biological aspect of ancestor with PANTHER:PTN000632293

(GO Reference Genome Project, 2011-)

enables GTP binding

inferred from sequence model

(Puhl et al., 2014)

inferred from biological aspect of ancestor with PANTHER:PTN000632293

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR001806

(InterPro Project Members, 2004-)

enables GTPase activity

inferred from sequence model

(Puhl et al., 2014)

inferred from electronic annotation with InterPro:IPR001806

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in anesthesia-resistant memory

inferred from mutant phenotype

(Murakami et al., 2017)

involved_in medium-term memory

inferred from mutant phenotype

(Murakami et al., 2017)

inferred from genetic interaction with FLYBASE:Pde4; FB:FBgn0000479

(Murakami et al., 2017)

inferred from genetic interaction with FLYBASE:Adcy1; FB:FBgn0003301

(Murakami et al., 2017)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in small GTPase-mediated signal transduction

inferred from sequence model

(Puhl et al., 2014)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in presynapse

inferred from direct assay

(Murakami et al., 2017)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in cytoplasmic side of plasma membrane

inferred from sequence model

(Puhl et al., 2014)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000632293

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

RGK GTPASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

GTPase activity
RHEA 19669:

Summaries

Gene Snapshot

Rad, Gem/Kir family member 1 (Rgk1) encodes a small GTPase involved in anesthesia-resistant and medium-term memory. [Date last reviewed: 2019-08-01]

Gene Group (FlyBase)

RGK GTPASES -: GTPases are an atypical family of the Ras superfamily of small GTPases. They are best known for their modulation of voltage-gated Ca²⁺ channels. (Adapted from FBrf0225550).

Summary (Interactive Fly)

small GTPase - intermediate-term memory generated after single cycle conditioning is divided into anesthesia-sensitive memory and anesthesia-resistant memory - expressed in the mushroom body - physically interacts with cacaphony

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Rgk1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A1ZBJ6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Rgk1-RA

FBtr0334282

NM_137567

1946

498

Rgk1-RB

FBtr0334283

NM_166341

5443

1379

Rgk1-RC

FBtr0334284

NM_001274158

3239

514

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Rgk1-PA

FBpp0306397

55.5

498

9.83

FBpp0306398

148.0

1379

9.57

FBpp0306399

57.2

514

9.58

A0A0B4KFV9

NP_001261087

AGB93619

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rgk1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.69

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

garland cell primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

dorsal pharyngeal muscle cell

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic/larval garland cell

(Fisher et al., 2012)

larval muscle system

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

adult stage

Kenyon cell

(Murakami et al., 2017)

Additional Descriptive Data

Rgk1-RC is the most abundant transcript isoform in the adult brain.

(Murakami et al., 2017)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

lobe system of mushroom body

(Murakami et al., 2017)

alpha/beta Kenyon cell

Comment: strong

(Murakami et al., 2017)

gamma Kenyon cell

Comment: strong

(Murakami et al., 2017)

alpha'/beta' Kenyon cell

Comment: weak

(Murakami et al., 2017)

calyx of adult mushroom body

(Murakami et al., 2017)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Dorus et al., 2006)

Additional Descriptive Data

Rgk1 protein is specifically expressed in Kenyon cells. Expression is stronger in the lobes than in the calyx or Kenyon cell bodies. Antibody specific to Rgk1-PB shows strong expression in the alpha/beta and gamma neurons and weak expression in the alpha'/beta' neurons. In the gamma lobes, Rgk1 protein is observed in puncta that colocalize with the brp signal and is thought to be associated with presynapses of Kenyon cells.

(Murakami et al., 2017)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in presynapse

inferred from direct assay

(Murakami et al., 2017)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Rgk1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Rgk1

View exonic expression by tissue for Dmel\Rgk1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264753

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

14462605/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264753

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264753

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9811

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 14 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Rgk1

Transgenic constructs containing regulatory region of Rgk1

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel6069

(Ryder, 2004.4.26)

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

Rgk1^GD14687

viable

Rgk1^f04245

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Rgk1^GD10002

viable, with Scer\GAL4^Mef2.PR

Rgk1^GD10002

viable, with Scer\GAL4^pnr-MD237

Rgk1^GD10002

Sterility

Allele

fertile

Rgk1^f04245

Other Phenotypes

Allele

abnormal memory | adult stage, with Scer\GAL4²⁷⁶⁵

Rgk1^RNAi.UAS

abnormal memory | adult stage, with Scer\GAL4^c739

Rgk1^RNAi.UAS

abnormal memory | adult stage, with Scer\GAL4^ey-OK107

abnormal memory | adult stage, with Scer\GAL4^Mef2.247

Rgk1^RNAi.UAS

abnormal memory | adult stage, with Scer\GAL4^NP5225

Rgk1^RNAi.UAS

abnormal memory | adult stage (with Df(2R)BSC26)

Rgk1^Δ

abnormal memory | adult stage | recessive

Rgk1^Δ

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (44)

Hsap\RRAD

5 of 14

Yes

4 of 14

4 of 14

4 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (35)

Rnor\Rrad

6 of 14

Yes

5 of 14

5 of 14

4 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (36)

Mmus\Rrad

6 of 14

Yes

5 of 14

5 of 14

4 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (29)

Xtro\gem

4 of 13

Yes

Xtro\rem2

4 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (35)

Drer\rrad

5 of 14

Yes

4 of 14

3 of 14

3 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkeyp-59c12.1

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (24)

Cele\Y52B11A.4

4 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (19)

Agam\AgaP_AGAP007681

4 of 12

Yes

Agam\AgaP_AGAP007615

3 of 12

Agam\AgaP_AGAP005243

2 of 12

Agam\AgaP_AGAP007680

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (19)

Atha\AT5G59840

1 of 13

Yes

Atha\ATFP8

1 of 13

Yes

Atha\RAB1A

1 of 13

Yes

Atha\RAB1C

1 of 13

Yes

Atha\RAB8

1 of 13

Yes

Atha\RAB11c

1 of 13

Yes

Atha\RAB18

1 of 13

Yes

Atha\RABA1d

1 of 13

Yes

Atha\RABA1g

1 of 13

Yes

Atha\RABA1i

1 of 13

Yes

Atha\RABA4a

1 of 13

Yes

Atha\RABA5d

1 of 13

Yes

Atha\RABB1a

1 of 13

Yes

Atha\RABE1c

1 of 13

Yes

Atha\RABE1e

1 of 13

Yes

Atha\RABG3E

1 of 13

Yes

Atha\RABH1c

1 of 13

Yes

Atha\RABH1d

1 of 13

Yes

Atha\RABH1e

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (8)

Scer\RAS1

1 of 13

Yes

Scer\RAS2

1 of 13

Yes

Scer\RHB1

1 of 13

Yes

Scer\RSR1

1 of 13

Yes

Scer\SEC4

1 of 13

Yes

Scer\VPS21

1 of 13

Yes

Scer\YPT1

1 of 13

Yes

Scer\YPT6

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\ras1

1 of 12

Yes

Spom\rhb1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Rgk1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (16)

6 of 13

5 of 13

5 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Ric

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RRAD; RRAD, Ras related glycolysis inhibitor and calcium channel regulator

5 of 14

179503

GEM; GTP binding protein overexpressed in skeletal muscle

4 of 14

600164

REM1; RRAD and GEM like GTPase 1

4 of 14

610388

REM2; RRAD and GEM like GTPase 2

4 of 14

616955

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

Rgk1 - Ubx

nucleic acid uv cross-linking assay, fluorescence technology, anti tag coimmunoprecipitation, quantitative reverse transcription pcr, fluorescent dye label

(Blanco et al., 2025, Carnesecchi et al., 2022)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Rgk1

enhanceable

Adcy1

(Murakami et al., 2017)

Rgk1

enhanceable

Pde4

(Murakami et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Adcy1

enhanceable

Rgk1

(Murakami et al., 2017)

Pde4

enhanceable

Rgk1

(Murakami et al., 2017)

Rac1

suppressible

Rgk1

(Murakami et al., 2017)

Rac1

enhanceable

Rgk1

(Murakami et al., 2017)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0264753

MIST (protein-protein) - An integrated Molecular Interaction Database

14462605

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-89

Cytogenetic map

56C10-56D1

Sequence location

2R:19,311,148..19,356,525 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

56C10-56D1

Limits computationally determined from genome sequence between P{PZ}ena⁰²⁰²⁹&P{lacW}cora^k08713 and P{lacW}hts^k06121

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-89

(FlyBase, 2016)

2-94.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (15)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

18749

w¹¹¹⁸; PBac{WH}Rgk1^f04245

23448

w¹¹¹⁸; Mi{ET1}Rgk1^MB02498

54517

y¹ w^*; Mi{MIC}Rgk1^MI10282

44350

y¹ w^*; Mi{MIC}CG34045^MI08022

30695

y¹ w^*; Mi{MIC}Rgk1^MI00298/CyO

52036

y¹ w^*; Mi{MIC}Rgk1^MI05539/SM6a

14343

y¹ w^67c23; P{SUPor-P}Rgk1^KG00183

66192

w¹¹¹⁸; PBac{IT.GAL4}Rgk1^2149-G4 fest^2149-G4/CyO

Kyoto

104909

y^* w^*; P{GawB}Rgk1^NP5225 / CyO, P{UAS-lacZ.UW14}UW14

NIG-Fly

HMJ21017

y¹ v¹; P{TRiP.HMJ21017}attP40/CyO

VDRC

v108710

P{KK106384}VIE-260B

v25574

w¹¹¹⁸; P{GD10002}v25574

More stocks available...

Genomic Clones (37)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (15)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE48016

Other clones

MIP17053

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0264753

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Murakami et al., 2017)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

New annotation (CG30127) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: Rgk1 CG30127

(FlyBase Genome Annotators, 2012)

Additional comments

Annotations CG9811 and CG30127 merged as CG44011 in release 5.47 of the genome annotation. Merge supported by RNA-seq junction data.

(FlyBase Genome Annotators, 2012)

Nomenclature History

Source for database identify of

Source for identity of: Rgk1 CG9811

(Smibert and Saint, 2003)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG30127

(Rodriguez et al., 2012, Keleman et al., 2009.8.5, Riedl et al., 2007)

CG44011

(National Institute of Genetics Fly Stocks, 2022-, FlyBase Genome Annotators, 2012, Ni et al., 2010.12.1)

CG9811

(Chen et al., 2012, Boutros et al., 2004, Colicelli, 2004, Solano et al., 2003)

CT27512

(Ceriani et al., 2002)

RGK1

(Puhl et al., 2014)

Rgk1

(Blanco et al., 2025, Jean-François et al., 2025, Bourouliti and Skoulakis, 2022, Baker et al., 2021, Lee et al., 2018, Franz et al., 2017, Clandinin and Owens, 2016-, Ou et al., 2016, Fear et al., 2015, Gene Disruption Project members, 2015-, Ashwal-Fluss et al., 2014, Diez et al., 2011, Napoletano et al., 2011, Hazelett et al., 2009, Riedl et al., 2007, Zeitlinger et al., 2007, Dorus et al., 2006)

rgk1

(Murakami et al., 2017)

Name Synonyms

Rad, Gem/Kir family member 1

Rgk1

Secondary FlyBase IDs

FBgn0034434
FBgn0050127

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

14462605

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A1ZBJ6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A1ZBJ6

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264753

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

14462605/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264753

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264753

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG44011

MARRVEL_MODEL - MARRVEL (model organism gene)

14462605

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0264753

DroID - A comprehensive database of gene and protein interactions.

FBgn0264753

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0264753

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9811

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC008856

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

14462605

References (61)

The following external sites may use different assemblies or annotations than FlyBase.

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