FlyBase Gene Report: Dmel\Rab19

General Information

Symbol

Dmel\Rab19

Species

D. melanogaster

Name

Rab19

Annotation Symbol

CG7062

Feature Type

protein_coding_gene

FlyBase ID

FBgn0015793

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Rab-RP3, DmRab19

Key Links

Genomic Location

Cytogenetic map

66C5-66C5

Sequence location

3L:8,297,018..8,298,506 [+]

Recombination map

3-24

RefSeq locus

NT_037436 REGION:8297018..8298506

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with FLYBASE:GCC88; FB:FBgn0037881,FLYBASE:Golgin97; FB:FBgn0086757

(Sinka et al., 2008)

inferred from physical interaction with FLYBASE:plx; FB:FBgn0261261

(Gillingham et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables GTP binding

inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR005225

(InterPro Project Members, 2004-)

enables GTPase activity

inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790

(Gene Ontology Curators, 2002-)

inferred from electronic annotation with InterPro:IPR001806

(InterPro Project Members, 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in enteroendocrine cell differentiation

inferred from mutant phenotype

(Nagy et al., 2017)

inferred from genetic interaction with FLYBASE:Atg16; FB:FBgn0039705

(Nagy et al., 2017)

inferred from genetic interaction with FLYBASE:sli; FB:FBgn0264089

(Nagy et al., 2017)

involved_in regulation of cell differentiation involved in tissue homeostasis

inferred from mutant phenotype

(Nagy et al., 2017)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in autophagosome assembly

inferred from biological aspect of ancestor with PANTHER:PTN000636233

(GO Reference Genome Project, 2011-)

involved_in Rab protein signal transduction

inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790

(Gene Ontology Curators, 2002-)

involved_in vesicle-mediated transport

inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790

(Gene Ontology Curators, 2002-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in Golgi apparatus

inferred from direct assay

(Gillingham et al., 2014, Sinka et al., 2008)

located_in neuronal cell body

inferred from direct assay

(Jin et al., 2012)

located_in recycling endosome

inferred from high throughput direct assay

(Chan et al., 2011)

located_in synapse

inferred from high throughput direct assay

(Chan et al., 2011)

inferred from direct assay

(Jin et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in vesicle

inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

RAB GTPASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

GTPase activity
RHEA 19669:

Summaries

Gene Group (FlyBase)

RAB GTPASES -: The Rab family are members of the Ras superfamily of small GTPases. Rabs regulate vesicle trafficking including cargo selection, vesicle budding, transport, docking and targeting. They localize to different intracellular compartments directed by specific isoprenylation of C-terminal motifs. (Adapted from PMID:15731001).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Rab19 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry O18339)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Rab19-RA

FBtr0076705

NM_079246

1033

219

Rab19-RB

FBtr0331832

NM_001274646

1062

219

Additional Transcript Data and Comments

Reported size (kB)

1.026 (longest cDNA)

(Satoh et al., 1997)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Rab19-PA

FBpp0076428

25.0

219

5.41

FBpp0304216

25.0

219

5.41

O18339

NP_001261575

AGB94270

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

219 aa isoforms: Rab19-PA, Rab19-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

O18339

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rab19 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

3.11

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 9 -- 10

amnioserosa

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic/larval garland cell

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in Golgi apparatus

inferred from direct assay

(Gillingham et al., 2014, Sinka et al., 2008)

located_in neuronal cell body

inferred from direct assay

(Jin et al., 2012)

located_in recycling endosome

inferred from high throughput direct assay

(Chan et al., 2011)

located_in synapse

inferred from high throughput direct assay

(Chan et al., 2011)

inferred from direct assay

(Jin et al., 2012)

Expression Deduced from Reporters

Reporter: PBac{I-SceI(FRT.Rab19-GAL4.ORF(loxP.3xP3-RFP))}

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage P6 -- P7

neuron | subset of pupal brain

Comment: 30-40h APF

(Chan et al., 2011)

glial cell | subset of pupal brain

Comment: 30-40h APF

(Chan et al., 2011)

neuropil glial sheath | intense

Comment: 30-40h APF

(Jin et al., 2012)

glial cell of second optic chiasma | faint

Comment: 30-40h APF

(Jin et al., 2012)

eye photoreceptor cell | faint

Comment: 30-40h APF

(Jin et al., 2012)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Rab19 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Rab19

View exonic expression by tissue for Dmel\Rab19

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015793

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38930/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015793

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015793

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015793

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7062

Flygut - An atlas of the Drosophila adult midgut

FBgn0015793

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Rab19

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Rab19

Transgenic constructs containing regulatory region of Rab19

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel6112

(Ryder, 2004.4.26)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die | heat sensitive

Rab19^Gal4-KO

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Rab19^GD10592

viable, with Scer\GAL4^Mef2.PR

Rab19^GD10592

viable, with Scer\GAL4^pnr-MD237

Rab19^GD10592

viable, with Scer\GAL4^tin.CΔ4

Rab19^GD10592

Sterility

Allele

fertile

Rab19^Gal4-KO

Other Phenotypes

Allele

abnormal developmental rate, with Df(3L)Exel6112

Rab19^Gal4-KO

abnormal developmental rate | P-stage

Rab19^Gal4-KO

abnormal immune response | adult stage (with Df(3L)BSC815)

Rab19^LL00490

abnormal neuroanatomy | adult stage

Rab19^Gal4-KO

abnormal neurophysiology | adult stage

Rab19^Gal4-KO

decreased size | adult stage

Rab19^Gal4-KO

increased cell number | adult stage (with Df(3L)BSC815)

Rab19^LL00490

increased size | adult stage, with Df(3L)Exel6112

Rab19^Gal4-KO

majority die during P-stage | heat sensitive

Rab19^Gal4-KO

short lived | heat sensitive

Rab19^Gal4-KO

visible | adult stage

Rab19^Gal4-KO

visible | adult stage, with Df(3L)Exel6112

Rab19^Gal4-KO

Phenotype manifest in

Allele

adult posterior midgut epithelium (with Df(3L)BSC815)

Rab19^LL00490

enteroblast | adult stage (with Df(3L)BSC815)

Rab19^LL00490

enteroendocrine cell | adult stage (with Df(3L)BSC815)

Rab19^LL00490

outer photoreceptor cell | adult stage

Rab19^Gal4-KO

retina

Rab19^Gal4-KO

rhabdomere of eye photoreceptor cell | adult stage

Rab19^Gal4-KO

wing

Rab19^Gal4-KO

wing, with Df(3L)Exel6112

Rab19^Gal4-KO

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (91)

Hsap\RAB43

12 of 14

Yes

Hsap\RAB19

10 of 14

Yes

Hsap\RAB1A

3 of 14

Hsap\RAB1B

3 of 14

Hsap\RAB12

2 of 14

Yes

Hsap\RAB15

2 of 14

Hsap\RAB30

2 of 14

Hsap\RAB33A

2 of 14

Yes

Hsap\RAB33B

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (51)

Rnor\Rab43

13 of 14

Yes

Rnor\Rab19

10 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Rnor\Rab33b

2 of 14

Yes

Rnor\Rab35

2 of 14

Rnor\Ift22

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (52)

Mmus\Rab43

13 of 14

Yes

Mmus\Rab19

10 of 14

Yes

Mmus\Rab1b

3 of 14

Mmus\Rab1a

2 of 14

Mmus\Rab12

2 of 14

Yes

Mmus\Rab15

2 of 14

Mmus\Rab30

2 of 14

Mmus\Rab33a

2 of 14

Yes

Mmus\Rab33b

2 of 14

Yes

Mmus\1700009N14Rik

1 of 14

Mmus\Ift22

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (54)

Xtro\rab19

8 of 13

Yes

Xtro\rab43

5 of 13

Yes

Xtro\rab1a

2 of 13

Xtro\rab12

2 of 13

Yes

Xtro\rab35l

2 of 13

Xtro\rab35

2 of 13

Xtro\cplane2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ift22

1 of 13

Yes

Xtro\ift27

1 of 13

Yes

Xtro\krasl

1 of 13

Xtro\kras

1 of 13

Xtro\MGC147600

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (64)

Drer\rab43

13 of 14

Yes

Drer\LOC555645

7 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Drer\zgc:171927

3 of 14

Drer\rab12

2 of 14

Drer\rab15

2 of 14

Yes

Drer\rab30

2 of 14

Drer\rab33a

2 of 14

Yes

Drer\rab33ba

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ift27

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (42)

Cele\rab-19

14 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

Yes

Cele\rab-35

2 of 14

Cele\4R79.2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (37)

Agam\AgaP_AGAP007096

12 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (59)

Atha\ATFP8

4 of 13

Yes

3 of 13

3 of 13

3 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

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1 of 13

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1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\SGP2

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (17)

Scer\YPT1

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (15)

Spom\ypt1

3 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Rab19. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (49)

5 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Ran

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Ric

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RAB43; RAB43, member RAS oncogene family

12 of 14

RAB19; RAB19, member RAS oncogene family

10 of 14

RAB1A; RAB1A, member RAS oncogene family

3 of 14

179508

RAB1B; RAB1B, member RAS oncogene family

3 of 14

612565

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Rab19 - Atg16

two hybrid, pull down, peptide massfingerprinting

(Nagy et al., 2017, Gillingham et al., 2014, Gillingham et al., 2014)

Rab19 - Atg5

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

Rab19 - GCC88

two hybrid, pull down, western blot

(Sinka et al., 2008)

Rab19 - Gdi

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

Rab19 - Golgin97

pull down, western blot, two hybrid

(Sinka et al., 2008)

Rab19 - Pi4KIIIα

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

Rab19 - plx

pull down, peptide massfingerprinting, anti tag western blot

(Gillingham et al., 2014, Gillingham et al., 2014, Gillingham et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Rab19

suppressible

sli

(Nagy et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Osbp

suppressible

Rab19

(Ma et al., 2012)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0015793

MIST (protein-protein) - An integrated Molecular Interaction Database

38930

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-24

Cytogenetic map

66C5-66C5

Sequence location

3L:8,297,018..8,298,506 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

66C5-66C5

Limits computationally determined from genome sequence between P{lacW}l(3)L0139^L0139 and P{PZ}Gug⁰³⁹²⁸&P{EP}CG6745^EP595b

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

66B-66C

(Ozaki, 1996.4.9)

66B-66C

(determined by in situ hybridisation)

(Satoh et al., 1997)

Experimentally Determined Recombination Data

Location

3-24

(FlyBase, 2016)

3-19.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

62552

w¹¹¹⁸; TI{TI}Rab19^EYFP

9800

y¹ w^*; P{UASp-YFP.Rab19.Q80L}06

50778

P{UASp-YFP.Rab19.Q80L}12, y¹ w^*

24150

y¹ w^*; P{UAST-YFP.Rab19}Hr39⁰²

23265

y¹ w^*; P{UASp-YFP.Rab19.Q80L}chn¹⁵

23239

y¹ w^*; P{UAST-YFP.Rab19.T35N}Dek⁰⁵/CyO

9799

y¹ w^*; P{UAST-YFP.Rab19.T35N}04/TM3, Sb¹

34607

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00592}attP2

7062R-4

v103653

v34190

w¹¹¹⁸; P{GD10592}v34190

v342375

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02480}attP40/CyO-GFP

More stocks available...

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (128)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE48347

Other clones

DPiM_RE48347

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0015793

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0015793

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA has been made from templates generated with primers directed against this gene.

(Kouranti et al., 2006)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Isolated from a Drosophila head cDNA library.

(Satoh et al., 1997)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Rab19 Rab-RP3

(FlyBase, 2009-)

Nomenclature comments

'Rab-RP3' renamed to 'Rab19' to standardize the nomenclature of D. melanogaster Rab genes in accordance with the nomenclature (based on orthology to human genes) used in FBrf0141628 and FBrf0201049.

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

AAF50452

(Armstrong, 2000)

CG7062

(Dunst et al., 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Sinka et al., 2008, Zhang et al., 2007, Colicelli, 2004)

DRABR3

(Kohno et al., 1994)

DRabRP3

(Satoh et al., 1997)

DmRab19

(Pereira-Leal and Seabra, 2001, Pereira-Leal and Seabra, 2001)

O18339

(Rojas et al., 2012)

Rab-RP3

(O'Sullivan et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Wasbrough et al., 2010, Sinka et al., 2008)

Rab-r3

Rab19/RP3

(Zhang et al., 2007)

Rab19s

(Ma et al., 2012)

rab19

(Lammers et al., 2017, Jin et al., 2012, Chan et al., 2011)

Name Synonyms

Rab-related protein 3

Rab19

rab-related protein 3

(Ozaki, 1996.4.9)

Secondary FlyBase IDs

Datasets (1)

Study focus (1)

Experimental Role

Project

Project Type

Title

bait_protein

Rab_Effectors_interaction_map

interactome

Interaction map generated by purification of most Rab factors, with identification of copurifying effectors by mass spectrometry.

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 41 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38930

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

O18339

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

O18339

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

O18339

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015793

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38930/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015793

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015793

FlyMine - An integrated database for Drosophila genomics

FBgn0015793

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7062

MARRVEL_MODEL - MARRVEL (model organism gene)

38930

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0015793

DroID - A comprehensive database of gene and protein interactions.

FBgn0015793

DRSC - Results frm RNAi screens

FBgn0015793

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015793

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0015793

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7062

Flygut - An atlas of the Drosophila adult midgut

FBgn0015793

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0015793

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC009113

MIST (protein-protein) - An integrated Molecular Interaction Database

38930

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (74)

The following external sites may use different assemblies or annotations than FlyBase.

3.11

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