Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\plx using the Feature Mapper tool.
plx protein is first detected in blastoderm embryos where it is distributed uniformly on the apical surface of the blastoderm cells. plx protein dimishes during gastrulation and is no longer detected by stage 9. plx protein is detected in the CNS starting in late stage 12 on the surface of neuronal cell bodies. Starting in stage 13, plx protein is detected on axon tracts that extend the entire length of the longitudinal connectives. Most axon fascicles that traverse the longitudinal connectives contain plx protein. No significant staining is observed in the commissures or lateral projecting axons. plx protein is also observed in the tracheal system from about stage 15. It is detected in the lumen of the large diameter major tracheal branches and lining the surface of its epithelium. While the dorsal and lateral trunks have high levels of staining, litlle or no staining is observed in smaller diameter trunks or in tracheoles. plx protein appears to be part of the trachea\'s cuticular extracellular matrix. plx protein may associate with or make up a part of the extracellular matrix substructure known as the endocuticle.
GBrowse - Visual display of RNA-Seq signalsView Dmel\plx in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: plx CG1093
Source for merge of: plx CG14674 CG34122
Annotations CG1093, CG14674 and CG34122 merged as CG42612 in release 5.20 of the genome annotation.
Identified as a candidate gene for hypoxia-specific selection (via an experimental evolution paradigm) that is also differentially expressed between control and hypoxia-adapted larvae.
New annotation (CG34122) in release 5.1 of the genome annotation.
plx protein is a novel membrane adhesion molecule. Loss of plx function results in a progressive fluid accumulation within the larva's tracheal network, culminating in congestion throughout the trachea and, ultimately, death.
"plx" ("pollux") and "cas" ("castor") are named after the Greek mythological brothers due to their close apposition.