FlyBase Gene Report: Dmel\Evi5

General Information

Symbol

Dmel\Evi5

Species

D. melanogaster

Name

Ecotropic viral integration site 5

Annotation Symbol

CG11727

Feature Type

protein_coding_gene

FlyBase ID

FBgn0262740

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Functions as a GTPase-activating protein (GAP). During border cell migration in the ovary, acts as a GAP for Rab11 and is necessary for the maintenance of active receptor tyrosine kinases at the leading edge. (UniProt, Q9VYY9)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

MRE21

Key Links

Genomic Location

Cytogenetic map

10B11-10B14

Sequence location

X:11,430,523..11,454,386 [-]

Recombination map

1-34

RefSeq locus

NC_004354 REGION:11430523..11454386

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables GTPase activator activity

inferred from direct assay

(Laflamme et al., 2012)

inferred from physical interaction with FLYBASE:Rab11; FB:FBgn0015790

(Laflamme et al., 2012)

enables small GTPase binding

inferred from physical interaction with FLYBASE:Rab11; FB:FBgn0015790

(Laflamme et al., 2012)

inferred from physical interaction with FLYBASE:Rab6; FB:FBgn0015797

(Gillingham et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables GTPase activator activity

inferred from biological aspect of ancestor with PANTHER:PTN000537561

(GO Reference Genome Project, 2011-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in regulation of cell migration

inferred from direct assay

(Laflamme et al., 2012)

involved_in regulation of protein localization

inferred from direct assay

(Laflamme et al., 2012)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Laflamme et al., 2012)

located_in Golgi apparatus

inferred from direct assay

(Gillingham et al., 2014)

colocalizes_with recycling endosome

inferred from direct assay

(Laflamme et al., 2012)

located_in vesicle

inferred from direct assay

(Laflamme et al., 2012)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

RAB GTPASE ACTIVATING PROTEINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

RAB GTPASE ACTIVATING PROTEINS -: RabGAPs are GTPase activating proteins for Rab family GTPases. RabGAPs share a common TBC (Tre-2/Bub2/Cdc16) domain. (Adapted from PMID:15731001 and FBrf0158741).

Protein Function (UniProtKB)

(UniProt, Q9VYY9)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Evi5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VYY9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.45

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Evi5-RA

FBtr0073547

NM_167285

5936

807

Evi5-RB

FBtr0073546

NM_132488

3177

779

Evi5-RC

FBtr0300732

NM_001169250

3159

773

Evi5-RD

FBtr0300733

NM_001169251

5156

801

Evi5-RE

FBtr0332620

NM_001272521

5423

773

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Evi5-PA

FBpp0073392

92.8

807

5.02

FBpp0073391

89.9

779

4.92

NP_572716

AAN09633

Evi5-PC

FBpp0289956

89.2

773

4.95

NP_001162721

ACZ95256

Evi5-PD

FBpp0289957

92.2

801

5.06

NP_001162722

ACZ95257

Evi5-PE

FBpp0304866

89.2

773

4.95

NP_001259450

AGB95293

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

773 aa isoforms: Evi5-PC, Evi5-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with Rab11.

(UniProt, Q9VYY9)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Evi5 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Evi5_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.02

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

pole plasm

Comment: maternally deposited

(Fisher et al., 2012)

organism

• pole plasm

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

primordial germ cell

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

salivary gland body primordium

Comment: reported as salivary gland primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 12 -- 16

presumptive embryonic salivary gland

(Herr and Harris, 2004)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic/larval salivary gland

(Fisher et al., 2012)

embryonic/larval salivary gland body

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

embryonic stage 16 -- 17

presumptive embryonic/larval central nervous system

(Herr and Harris, 2004)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Laflamme et al., 2012)

located_in Golgi apparatus

inferred from direct assay

(Gillingham et al., 2014)

colocalizes_with recycling endosome

inferred from direct assay

(Laflamme et al., 2012)

located_in vesicle

inferred from direct assay

(Laflamme et al., 2012)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Evi5 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Evi5

View exonic expression by tissue for Dmel\Evi5

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0262740

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32088/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262740

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030299

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262740

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11727

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Evi5

Transgenic constructs containing regulatory region of Evi5

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene partially disrupted in

Df(1)CRIMIC-CR70046

(Gene Disruption Project members, 2018-)

Inferred from location ( 10 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Evi5^KG00813

viable, with Scer\GAL4^Mef2.PR

Evi5^GD6735

viable, with Scer\GAL4^pnr-MD237

Evi5^GD6735

Sterility

Allele

fertile

Evi5^KG00813

Other Phenotypes

Allele

abnormal cell migration, with Scer\GAL4^c306

abnormal cell migration, with Scer\GAL4^slbo.2.6

Evi5^UAS.mCherry

Phenotype manifest in

Allele

border follicle cell, with Scer\GAL4^c306

border follicle cell, with Scer\GAL4^slbo.2.6

Evi5^UAS.mCherry

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (48)

Hsap\EVI5

13 of 14

Yes

Hsap\EVI5L

12 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (32)

Rnor\Evi5

13 of 14

Yes

Rnor\Evi5l

8 of 14

Yes

3 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (30)

Mmus\Evi5

13 of 14

Yes

Mmus\Evi5l

11 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (19)

Xtro\evi5

11 of 13

Yes

Xtro\evi5l

7 of 13

Yes

3 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (35)

Drer\evi5b

12 of 14

Yes

Drer\evi5l

12 of 14

Yes

Drer\evi5a

7 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

1 of 14

Yes

Drer\grtp1a

1 of 14

Drer\grtp1b

1 of 14

Drer\sgsm3

1 of 14

Drer\si:ch211-266k8.4

1 of 14

Drer\si:ch211-288d18.1

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (19)

Cele\eat-17

12 of 14

Yes

3 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (18)

Agam\AgaP_AGAP002354

11 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (19)

Atha\AT3G02460

7 of 13

Yes

5 of 13

3 of 13

3 of 13

3 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (8)

Scer\GYP5

7 of 13

Yes

Scer\GYL1

5 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (11)

Spom\gyp51

6 of 12

Yes

Spom\SPCC1620.12c

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Evi5. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (21)

GAPcenA

7 of 13

plx

6 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

wkd

3 of 13

blobby

2 of 13

CG1695

2 of 13

tbc

2 of 13

CG3703

1 of 13

CG17883

1 of 13

sky

1 of 13

TBC1D23

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

EVI5; ecotropic viral integration site 5

13 of 14

602942

EVI5L; ecotropic viral integration site 5 like

12 of 14

RABGAP1; RAB GTPase activating protein 1

3 of 14

615882

RABGAP1L; RAB GTPase activating protein 1 like

3 of 14

609238

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Evi5 - Fer1HCH

anti tag coimmunoprecipitation, Identification by mass spectrometry, anti tag western blot

(Soltani et al., 2024)

Evi5 - Irbp18

two hybrid

(Hu et al., 2017.6.13)

Evi5 - Rab11

pull down, anti tag western blot

(Laflamme et al., 2012)

Evi5 - Rab14

pull down, anti tag western blot, two hybrid

(Gillingham et al., 2014)

Evi5 - Rab6

pull down, peptide massfingerprinting, two hybrid, anti tag western blot

(Gillingham et al., 2014, Gillingham et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Interacts with Rab11.

(UniProt, Q9VYY9 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262740

MIST (protein-protein) - An integrated Molecular Interaction Database

32088

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-34

Cytogenetic map

10B11-10B14

Sequence location

X:11,430,523..11,454,386 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

10B11-10B14

Limits computationally determined from genome sequence between P{EP}CG11756^EP1610 and P{EP}CG32666^EP1452

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-34

(FlyBase, 2016)

1-36.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

38350

y¹ v¹; P{TRiP.HMS01818}attP40

62760

w¹¹¹⁸ PBac{IT.GAL4}Evi5^0291-G4

93934

y¹ w^* TI{CRIMIC.TG4.0}Evi5^{CR02602-TG4.0}/FM7h

10609

v105146

v17549

w¹¹¹⁸; P{GD6735}v17549/TM3

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (56)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0262740

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Both loss and gain of Evi5 function blocks border cell migration by disrupting the Rab11-dependent polarization of active guidance receptors.

(Laflamme et al., 2012)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG11727 BcDNA:LD11130

(FlyBase, 1996-)

Source for merge of: BcDNA:LD11130 BcDNA:GH08923

(FlyBase, 1996-)

Source for merge of: CG11727 MRE21

(FlyBase Genome Annotators, 2011)

Additional comments

MRE21 is part of the 3' UTR of CG11727.

(FlyBase Genome Annotators, 2011)

MRE21 corresponds to a portion of the 3' UTR of CG11727.

(FlyBase Genome Annotators, 2011)

Source for merge of CG11727 BcDNA:LD11130 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Source for merge of BcDNA:LD11130 BcDNA:GH08923 was TrEMBL update ( date:020807 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Evi5 CG11727

(Laflamme et al., 2012)

Nomenclature comments

Etymology

Named "Evi5" after the human ortholog.

(FlyBase, 2009-)

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

BcDNA:GH08923

BcDNA:LD11130

CG11727

(Gillingham et al., 2014, Gabernet-Castello et al., 2013, Wit et al., 2013, Laflamme et al., 2012, Smibert et al., 2012, FlyBase Genome Annotators, 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Wittkopp et al., 2008)

Evi5

(Lee et al., 2023, Pang et al., 2021, Gene Disruption Project members, 2018-, Hu et al., 2017.6.13, Clandinin and Owens, 2016-, Hsu et al., 2015, Laflamme and Emery, 2015, Gillingham et al., 2014)

MRE21

(FlyBase Genome Annotators, 2011, Kageyama, 2007.2.28, Inagaki et al., 2005)

Name Synonyms

Ecotropic viral integration site 5

Ecotropic viral integration site 5 ortholog

mRNA-like ncRNA in embryogenesis 21

Secondary FlyBase IDs

FBgn0030299
FBgn0046801
FBgn0047215
FBgn0086552

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 51 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32088

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VYY9

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VYY9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q95NS4

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VYY9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0262740

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32088/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262740

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262740

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG11727

MARRVEL_MODEL - MARRVEL (model organism gene)

32088

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0262740

DroID - A comprehensive database of gene and protein interactions.

FBgn0262740

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Evi5_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030299

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0262740

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11727

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

MIST (protein-protein) - An integrated Molecular Interaction Database

32088

References (48)

The following external sites may use different assemblies or annotations than FlyBase.

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