FlyBase Gene Report: Dmel\Vha26

General Information

Symbol

Dmel\Vha26

Species

D. melanogaster

Name

Vacuolar H⁺-ATPase 26kD subunit

Annotation Symbol

CG1088

Feature Type

protein_coding_gene

FlyBase ID

FBgn0283535

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Vacuolar H[+]-ATPase 26kD subunit (Vha26) encodes the E subunit of the V1 domain of the vacuolar ATPase that is required for the morphology of tracheal cells. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Vacuolar H⁺-ATPase 26kD E subunit, oak gall, vATPase, ATP6V1E1

Key Links

Genomic Location

Cytogenetic map

83B4-83B4

Sequence location

3R:5,591,763..5,595,356 [+]

Recombination map

3-47.5

RefSeq locus

NT_033777 REGION:5591763..5595356

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

contributes_to proton-transporting ATPase activity, rotational mechanism

inferred by curator from GO:0033181

(Allan et al., 2005)

enables proton-transporting ATPase activity, rotational mechanism

inferred from biological aspect of ancestor with PANTHER:PTN005238491

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR002842

(InterPro Project Members, 2004-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in apical protein localization

inferred from mutant phenotype

(Francis and Ghabrial, 2015)

involved_in liquid clearance, open tracheal system

inferred from high throughput mutant phenotype

(Ghabrial et al., 2011)

involved_in terminal branching, open tracheal system

inferred from mutant phenotype

(Francis and Ghabrial, 2015)

inferred from high throughput mutant phenotype

(Ghabrial et al., 2011)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in proton transmembrane transport

inferred by curator from GO:0033181

(Allan et al., 2005)

inferred from electronic annotation with InterPro:IPR002842

(InterPro Project Members, 2004-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

part_of plasma membrane proton-transporting V-type ATPase complex

inferred from mutant phenotype

(Allan et al., 2005)

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of proton-transporting two-sector ATPase complex, catalytic domain

inferred from electronic annotation with InterPro:IPR002842

(InterPro Project Members, 2004-)

part_of vacuolar proton-transporting V-type ATPase, V1 domain

inferred from sequence or structural similarity with SGD:S000005859

(Dow, 1999)

Gene Group (FlyBase)

VACUOLAR ATPASE V1 DOMAIN NON-CATALYTIC SUBUNITS

Protein Family (UniProt)

Belongs to the V-ATPase E subunit family. (P54611)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

proton-transporting ATPase activity, rotational mechanism
RHEA 57721:

Summaries

Gene Snapshot

Vacuolar H[+]-ATPase 26kD subunit (Vha26) encodes the E subunit of the V1 domain of the vacuolar ATPase that is required for the morphology of tracheal cells. [Date last reviewed: 2019-09-26]

Gene Group (FlyBase)

VACUOLAR ATPASE V1 DOMAIN NON-CATALYTIC SUBUNITS -: The V1 domain of V-ATPases is a peripheral membrane domain composed of eight different subunits (A-H) that are expressed as multiple isoforms in a tissue-specific manner. The V1 domain is responsible for ATP hydrolysis. The non-catalytic V1 subunits do not hydrolyze ATP directly but provide regulatory functions and/or interact with the V0 domain. (Adapted from PMID:20450191 and FBrf0188241).

Protein Function (UniProtKB)

Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).

(UniProt, P54611)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Vha26 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P54611)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Vha26-RA

FBtr0078701

NM_169073

2269

226

Vha26-RB

FBtr0078700

NM_079513

2171

226

Vha26-RC

FBtr0346137

NM_001300253

2926

226

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Vha26-PA

FBpp0078350

26.1

226

5.96

FBpp0078349

26.1

226

5.96

FBpp0311965

26.1

226

5.96

P54611

NP_001287182

AHN57181

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

226 aa isoforms: Vha26-PA, Vha26-PB, Vha26-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2 (By similarity).

(UniProt, P54611)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Vha26 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.81

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

seminal receptacle

(Prokupek et al., 2009)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic hindgut

(Fisher et al., 2012)

embryonic midgut chamber

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

adult stage

adult hindgut

(Allan et al., 2005)

adult posterior hindgut

(Allan et al., 2005)

adult Malpighian tubule

(Allan et al., 2005)

adult stage | male

ejaculatory bulb

(Allan et al., 2005)

ejaculatory duct

(Allan et al., 2005)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of plasma membrane proton-transporting V-type ATPase complex

inferred from mutant phenotype

(Allan et al., 2005)

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Vha26 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Vha26

View exonic expression by tissue for Dmel\Vha26

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015324

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40679/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0283535

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015324

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0283535

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1088

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Vha26

Transgenic constructs containing regulatory region of Vha26

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3R)Exel6144

(Francis and Ghabrial, 2015, Ryder, 2004.4.26)

Df(3R)noi-C

(Meyer et al., 1998)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Vha26^CC01380

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Vha26^GD7112

lethal, with Scer\GAL4^Mef2.PR

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Vha26^GD7112

lethal - all die during embryonic stage

Vha26^j3E7

viable, with Scer\GAL4^tin.CΔ4

Vha26^GD7112

Other Phenotypes

Allele

abnormal cell adhesion | somatic clone | third instar larval stage

Vha26^okg-696

abnormal cell shape | somatic clone | third instar larval stage

Vha26^okg-696

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

Vha26^GD7112

some die during embryonic stage

Vha26^j3E7

some die during pupal stage, with Scer\GAL4^pnr-MD237

Vha26^GD7112

Phenotype manifest in

Allele

embryonic/larval tracheal dorsal trunk

Vha26^okg-696

embryonic/larval tracheal stalk cell | third instar larval stage

Vha26^okg-696

embryonic/larval tracheal stalk cell | third instar larval stage, with Scer\GAL4^bs.PM

Vha26^GD7112

eye | somatic clone

Vha26^okg-696

larval tracheal system

Vha26^okg-696

Malpighian tubule

Vha26^j3E7

terminal tracheal cell

Vha26^okg-696

terminal tracheal cell | somatic clone | third instar larval stage

Vha26^okg-696

terminal tracheal cell | third instar larval stage, with Scer\GAL4^bs.PM

Vha26^GD7112

yolk granule | absent, with Scer\GAL4^{VP16.mat.αTub67C}

Vha26^HMS01912

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (2)

Hsap\ATP6V1E1

14 of 14

Yes

Hsap\ATP6V1E2

12 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (2)

Rnor\Atp6v1e1

14 of 14

Yes

Rnor\Atp6v1e2

12 of 14

Yes

Mus musculus (laboratory mouse) (2)

Mmus\Atp6v1e1

13 of 14

Yes

Mmus\Atp6v1e2

12 of 14

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\atp6v1e1

8 of 13

Yes

Danio rerio (Zebrafish) (2)

Drer\atp6v1e1b

14 of 14

Yes

Drer\atp6v1e1a

13 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\vha-8

14 of 14

Yes

Cele\clec-73

1 of 14

Yes

Cele\clec-79

1 of 14

Yes

Cele\clec-117

1 of 14

Yes

Cele\clec-123

1 of 14

Yes

Cele\clec-175

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP002401

12 of 12

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\VHA-E2

13 of 13

Yes

Atha\TUF

12 of 13

Yes

Atha\VHA-E3

12 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\VMA4

12 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\vma4

12 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Vha26. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

ATP6V1E1; ATPase H+ transporting V1 subunit E1

model of autosomal recessive cutis laxa type IIC

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ATP6V1E1; ATPase H+ transporting V1 subunit E1

14 of 14

108746

CUTIS LAXA, AUTOSOMAL RECESSIVE, TYPE IIC; ARCL2C

autosomal recessive cutis laxa type IIC

ATP6V1E2; ATPase H+ transporting V1 subunit E2

12 of 14

617385

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Vha26 - CG5126

experimental knowledge based

(Guruharsha et al., 2011)

Vha26 - CG8888

experimental knowledge based

(Guruharsha et al., 2011)

Vha26 - Coq6

experimental knowledge based

(Guruharsha et al., 2011)

Vha26 - Fmo1

experimental knowledge based

(Guruharsha et al., 2011)

Vha26 - Hmgs

experimental knowledge based

(Guruharsha et al., 2011)

Vha26 - Myc

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Vha26 - Pcyt2

experimental knowledge based

(Guruharsha et al., 2011)

Vha26 - Vha14-1

experimental knowledge based

(Guruharsha et al., 2011)

Vha26 - Vha36-1

experimental knowledge based

(Guruharsha et al., 2011)

Vha26 - Vha44

experimental knowledge based

(Guruharsha et al., 2011)

Vha26 - Vha55

experimental knowledge based

(Guruharsha et al., 2011)

Vha26 - Vha68-1

experimental knowledge based

(Guruharsha et al., 2011)

Vha26 - Vha68-2

experimental knowledge based

(Guruharsha et al., 2011)

Vha26 - VhaSFD

experimental knowledge based

(Guruharsha et al., 2011)

Vha26 - nwk

experimental knowledge based

(Guruharsha et al., 2011)

RNA-protein

Physical Interaction

Assay

References

Vha26 - stau

anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization

(Laver et al., 2013)

RNA-RNA

Physical Interaction

Assay

References

Vha26 - mir-8

quantitative reverse transcription pcr, western blot, luminiscence technology

(Lim et al., 2020)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Mitf

suppressible

Vha26

(Zhang et al., 2015)

External Data

Subunit Structure (UniProtKB)

(UniProt, P54611 )

Linkouts

MIST (protein-protein) - An integrated Molecular Interaction Database

40679

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene

(Ghabrial et al., 2011)

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47.5

Cytogenetic map

83B4-83B4

Sequence location

3R:5,591,763..5,595,356 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

83B4-83B4

Limits computationally determined from genome sequence between P{PZ}Snr1⁰¹³¹⁹&P{PZ}Itp-r83A⁰⁵⁶¹⁶ and P{lacW}Atu^s1938

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

84A-84B

(Guo, 1995.10.19)

83B-83B

(Dow, 1999, Dow et al., 1997)

83B1-83B4

(determined by in situ hybridisation)

(Guo et al., 1996)

Experimentally Determined Recombination Data

Location

3-47.5

(FlyBase, 2016)

3-44.1

(Comeron et al., 2012)

(Ghabrial et al., 2011, Guo, 1995.10.19)

Left of (cM)

Right of (cM)

Notes

Maps to 3R.

(Ghabrial et al., 2011)

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

38996

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01912}attP2/TM3, Sb¹

10214

w¹¹¹⁸; P{lacW}Vha26^j3E7/TM3, P{ftz-lacC}SC1, ry^RK Sb¹ Ser¹

63107

w^*; P{GAL4-btl.S}2, P{UASp-Act5C.T:GFP}2; P{FRT(w^hs)}2A P{neoFRT}82B Vha26^okg-696/TM3, P{tubP-GAL80}3, Sb¹

1088R-1

v102378

v45377

w¹¹¹⁸; P{GD7112}v45377/TM3

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (226)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH03683

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0283535

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene.

(Hansen et al., 2009)

dsRNA made from templates generated with primers directed against Vha26 that is transfected into S2 treated with Listeria monocytogenes reveals Vha26 to be involved in Listeria monocytogenes entry and vacuolar escape.

(Cheng et al., 2005)

Transcription unit identified during molecular analysis of the noi gene region.

(Meyer et al., 1998)

Isolated using a M.sexta V-ATPase E-subunit cDNA.

(Guo et al., 1996)

Vha26 has been cloned and characterised.

(Guo et al., 1996)

Relationship to Other Genes

Source for database merge of

Source for merge of: Vha26 BcDNA:GH03683

(FlyBase, 1996-)

Source for merge of: Vha26 anon-83Bb

(FlyBase, 1996-)

Source for merge of: Vha26 oak-gall

(Francis and Ghabrial, 2015)

Additional comments

Source for merge of Vha26 BcDNA:GH03683 was sequence comparison ( date:990717 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Vha26 CG1088

(Zheng, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (19)

Reported As

Symbol Synonym

ATP6V1E1

(Griciuc et al., 2014, Adamson et al., 2011)

BcDNA.GH03683

(Rubin, 1999.4.23)

BcDNA:GH03683

CG1088

(Laffafian and Tepass, 2019, Kolkhof et al., 2017, Rosa-Ferreira et al., 2015, Cammarato et al., 2011, Khanna et al., 2010, Ni et al., 2010.12.1, Hansen et al., 2009, Keleman et al., 2009.8.5, Allan et al., 2005, Wang et al., 2004, Labourier et al., 2002)

VhaE

anon-83Bb

chr3R:1419698..1419836

(Will et al., 2013)

oak-gall

okg

(Francis and Ghabrial, 2015)

vATPase

(Pradhan et al., 2023, Whyard et al., 2009)

vha26

(Gupta et al., 2014, Wang et al., 2014, Chintapalli et al., 2013, Adamson et al., 2011, Rose et al., 2011, Allan et al., 2005, Cheng et al., 2005, Stark et al., 2005, Wang et al., 2004, Dow, 1999, Dow et al., 1997, Guo et al., 1996, Guo, 1995.10.10, Guo, 1995.10.19)

Name Synonyms

E subunit

(Dow et al., 1997)

Vacuolar H+ATPase subunit E

(Sun et al., 2007)

Vacuolar H+-ATPase 26 kD E subunit

(Bozoky et al., 2009)

Vacuolar H+-ATPase 26kD E subunit

(Laver et al., 2013, Cammarato et al., 2011, Khanna et al., 2010)

Vacuolar H+-ATPase 26kD subunit

oak gall

(Francis and Ghabrial, 2015, Ghabrial et al., 2011)

vacuolar ATP synthase subunit E

(Domanitskaya et al., 2007)

Secondary FlyBase IDs

FBgn0015324
FBgn0024707
FBgn0264655

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 49 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40679

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P54611

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P54611

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4LGS4

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P54611

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015324

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40679/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0283535

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0283535

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1088

MARRVEL_MODEL - MARRVEL (model organism gene)

40679

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0283535

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015324

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0283535

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1088

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC010367

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

40679

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (120)

The following external sites may use different assemblies or annotations than FlyBase.

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