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General Information
Name
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS
Species
D. melanogaster
Symbol
BHLH
FlyBase ID
FBgg0000727
Date last reviewed
2017-06-07
Number of members
59
Description
Description

Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).

Notes on Group
Source Material
The BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS Gene Group has been compiled by FlyBase curators using the following publication(s): Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, and Ledent and Vervoort, 2001 .
Key Gene Ontology (GO) terms
Cellular Component
Related Gene Groups
Members (59)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Enhancer of split m3, helix-loop-helix
m3, E(spl)m3, HLHm3, E(spl)C m3, E(spl) region transcript m3
Enhancer of split m5, helix-loop-helix
m5, E(spl)m5, HLHm5, HLH-m5, E(spl) region transcript m5
Enhancer of split m7, helix-loop-helix
m7, E(spl)m7, HLHm7, E(spl) region transcript m7, HLH-m7
Enhancer of split m8, helix-loop-helix
m8, E(spl)m8, E(spl), Enhancer of split, E(spl)-m8
Enhancer of split mβ, helix-loop-helix
E(spl)mβ, mβ, HLHmβ, HLHmbeta, E(spl)-mβ
Enhancer of split mδ, helix-loop-helix
mδ, E(spl)mδ, HLHmdelta, HLHmδ, E(spl)mdelta
Enhancer of split mγ, helix-loop-helix
mγ, E(spl)mγ, HLHmγ, HLHmgamma, E(spl) region transcript mγ
extra macrochaetae
l(3)05592, ms(3)61CD, Ach, extramacrochaete, gov
germ cell-expressed bHLH-PAS
Germ cell-expressed, germ-cell expressed
knot
col, collier, knotted, collier/knot
Methoprene-tolerant
Rst(1)JH, DmMet, Resistance to Juvenile Hormone
Mnt
dMnt, dMad, Mad, EG:114E2.2, Mad-3E
Sterol regulatory element binding protein
dSREBP, HLH106, SREBF1, l(3)76BDw, Helix loop helix protein 106
taiman
l(2)01351, l(2)k05809, DAIB1, l(2)k05802
External Data
Synonyms and Secondary IDs
Synonym(s)
BHLH
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS
Basic helix loop helix proteins
Secondary FlyBase ID(s)
References (5)