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FB2025_04
,
released October 2, 2025
lats, Warts/Lats, large tumor suppressor, LATS1, miracle-gro
a tumor suppressor kinase - regulates cell cycle - loss of gene function leads to the cell-autonomous formation of epithelial tumors in the adult integumentary structures derived from imaginal discs - plays a post-mitotic role in R8 photoreceptor cells where it antagonizes melt to control the bistable choice of Rhodospin expression
Please see the JBrowse view of Dmel\wts for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
~6 (northern blot)
5.7, 4.7 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
1099 (aa)
Interacts with yki. Interacts with jub.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wts using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reference states 0-4 hr AEL
JBrowse - Visual display of RNA-Seq signals
View Dmel\wts in JBrowse3-101
3-98.7
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
wts seems to have a crucial role in dendrite-specific morphogenesis.
In wts mutants, dendrites initially tile the body wall normally, but progressively lose branches at later larval stages, whereas the axon shows no obvious defects.
wts acts cell autonomously in class IV neurons.
dsRNA made from templates generated with primers directed against this gene is tested in an S2 cell phosphorylation experiment to assess teh hpo signal transduction pathway.
wts is a potential negative regulator of Jak/STAT signaling
Involved in restricting tracheal terminal cell growth and branching.
wts is required to induce the photoreceptor cell R8 of yellow ommatidium fate and to repress the photoreceptor cell R8 of pale ommatidium fate.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells seen.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Some of the proteins of apico-lateral junctions are required both for apico-basal cell polarity and for the signalling mechanisms controlling cell proliferation, whereas others are required more specifically in cell-cell signalling.
Molecular and genetic characterisation of wts reveals that wts encodes a predicted novel protein kinase. Mitotic recombination analysis demonstrates wts is required for the control of the amount and direction of cell proliferation as well as for normal cell morphogenesis. Loss of wts leads to a cell-autonomous formation of epithelial tumours in the adult integumentary structures derived from imaginal discs. wts is a tumour suppressor gene.
Mutants display hyperplastic phenotype, showing tissue overgrowth in mitotic recombination clones.
One of the introns of wts has the sequence and structural characteristics of a "mirtron"- mirtrons are encoded as an intron of another gene which accumulate as a lariats after splicing and require debranching enzyme for conversion into a functional miRNA. The mirtron encoded by the wts intron is mir-1013.
Source for identity of: wts miracle-gro
