FlyBase Gene Report: Dmel\Abca3

General Information

Symbol

Dmel\Abca3

Species

D. melanogaster

Name

ATP binding cassette subfamily A member 3

Annotation Symbol

CG1718

Feature Type

protein_coding_gene

FlyBase ID

FBgn0031170

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

ABCA, dABCA

Key Links

Genomic Location

Cytogenetic map

19F3-19F3

Sequence location

X:21,292,308..21,306,665 [-]

Recombination map

1-65

RefSeq locus

NC_004354 REGION:21292308..21306665

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ABC-type transporter activity

inferred from electronic annotation with InterPro:IPR013525, InterPro:IPR026082

(InterPro Project Members, 2004-)

enables ATP binding

inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR017871

(InterPro Project Members, 2004-)

enables ATP hydrolysis activity

inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR017871

(InterPro Project Members, 2004-)

enables ATPase-coupled transmembrane transporter activity

inferred from sequence or structural similarity with UniProtKB:O94911

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000442469

(GO Reference Genome Project, 2011-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in transmembrane transport

inferred from electronic annotation with InterPro:IPR026082

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR013525, InterPro:IPR026082

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with UniProtKB:Q9BZC7

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

ABCA ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

ATP hydrolysis activity
RHEA 13065:

Summaries

Gene Group (FlyBase)

ABCA ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY -: The ATP-binding cassette (ABC) transporter family are primary active transporters that use ATP hydrolysis to drive the transport of substrates across the membrane. The ABCA subfamily are full transporters, encoding the functional transporter in one polypeptide. (Adapted from FBrf0224053).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Abca3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VRG4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.45

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Abca3-RB

FBtr0306679

NM_134601

6793

1714

Abca3-RC

FBtr0332488

NM_001272835

5542

1709

Abca3-RD

FBtr0332489

NM_001272836

6336

1692

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Abca3-PB

FBpp0297618

193.1

1714

6.55

FBpp0304764

192.6

1709

6.31

FBpp0304765

190.5

1692

6.13

M9PHQ1

NP_001259765

AGB95603

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Abca3 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.89

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Abca3 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Abca3

View exonic expression by tissue for Dmel\Abca3

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031170

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33103/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031170

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031170

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031170

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1718

Flygut - An atlas of the Drosophila adult midgut

FBgn0031170

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Abca3

Transgenic constructs containing regulatory region of Abca3

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 23 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of P-stage, with Scer\GAL4^eya.enh1+E+2

Abca3^HMS01821

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Abca3^GD3708

viable, with Scer\GAL4^Mef2.PR

Abca3^GD3708

viable, with Scer\GAL4^pnr-MD237

Abca3^GD3708

viable, with Scer\GAL4^tin.CΔ4

Abca3^GD3708

Other Phenotypes

Allele

abnormal behavior | adult stage, with Scer\GAL4^elav.PLu

Abca3^GD3708

abnormal behavior | adult stage | male limited, with Scer\GAL4^elav.PLu

Abca3^HMS01796

abnormal learning | larval stage, with Scer\GAL4^elav.PLu

Abca3^GD3708

abnormal locomotor rhythm | adult stage, with Scer\GAL4^elav.PLu

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^elav.PLu

increased rate of movement | adult stage, with Scer\GAL4^elav.PLu

Abca3^GD3708

Phenotype manifest in

Allele

egg chamber, with Scer\GAL4^GR1

Abca3^HMS01821

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^elav.PLu

NMJ bouton | increased number | third instar larval stage, with Scer\GAL4^elav.PLu

Abca3^GD3708

NMJ bouton | third instar larval stage, with Scer\GAL4^elav.PLu

nurse cell, with Scer\GAL4^GR1

Abca3^HMS01821

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (25)

Hsap\ABCA3

14 of 14

Yes

Hsap\ABCA4

8 of 14

Yes

Hsap\ABCA7

8 of 14

Yes

Hsap\ABCA1

7 of 14

Yes

Hsap\ABCA2

7 of 14

Yes

Hsap\ABCA12

7 of 14

Hsap\ABCA6

6 of 14

Yes

Hsap\ABCA8

6 of 14

Yes

Hsap\ABCA9

6 of 14

Yes

Hsap\ABCA10

6 of 14

Yes

6 of 14

5 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (18)

Rnor\Abca3

13 of 14

Yes

Rnor\Abca15

13 of 14

Yes

Rnor\Abca17

13 of 14

Yes

Rnor\Abca14

12 of 14

Yes

Rnor\Abca16

12 of 14

Yes

Rnor\Abca7

9 of 14

Yes

Rnor\Abca4

8 of 14

Yes

Rnor\Abca2

7 of 14

Yes

Rnor\Abca12

7 of 14

Yes

Rnor\Abca1

6 of 14

Yes

Rnor\Abca6

6 of 14

Yes

Rnor\Abca5

5 of 14

Rnor\Abca8a

5 of 14

Yes

Rnor\Abca8

5 of 14

Yes

Rnor\Abca9

5 of 14

Yes

Rnor\Abca13

5 of 14

Yes

Rnor\Abcb4

1 of 14

Rnor\Cftr

1 of 14

Mus musculus (laboratory mouse) (18)

Mmus\Abca3

14 of 14

Yes

Mmus\Abca14

13 of 14

Yes

Mmus\Abca15

13 of 14

Yes

Mmus\Abca16

13 of 14

Yes

Mmus\Abca17

13 of 14

Yes

Mmus\Abca1

7 of 14

Yes

Mmus\Abca2

7 of 14

Yes

Mmus\Abca4

7 of 14

Yes

Mmus\Abca7

7 of 14

Yes

Mmus\Abca6

6 of 14

Yes

Mmus\Abca8b

6 of 14

Yes

Mmus\Abca9

6 of 14

Yes

6 of 14

6 of 14

5 of 14

5 of 14

Yes

Mmus\Abcb1a

1 of 14

Mmus\Abcb4

1 of 14

Xenopus tropicalis (Western clawed frog) (18)

Xtro\abca3

7 of 13

Yes

Xtro\abca4

5 of 13

Yes

Xtro\abca2

4 of 13

Yes

Xtro\abca1

3 of 13

Yes

Xtro\lsm3

3 of 13

Xtro\abca5

2 of 13

Xtro\abca8

2 of 13

Yes

Xtro\abca9

2 of 13

Yes

Xtro\abca10

2 of 13

Xtro\pak1ip1

2 of 13

Yes

Xtro\abca12

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC116406449

1 of 13

Xtro\ptar1

1 of 13

Xtro\tomm22

1 of 13

Danio rerio (Zebrafish) (18)

Drer\abca3b

13 of 14

Yes

Drer\abca4b

8 of 14

Yes

Drer\abca1b

7 of 14

Yes

Drer\abca1a

6 of 14

Yes

Drer\abca4a

6 of 14

Yes

Drer\abca7

5 of 14

Yes

Drer\abca12

5 of 14

Drer\abca5

4 of 14

Drer\abca2

3 of 14

Yes

Drer\si:cabz01083442.1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\wu:fb13g09

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (21)

Cele\abt-4

14 of 14

Yes

Cele\abt-2

8 of 14

Yes

Cele\abt-5

7 of 14

Yes

Cele\ced-7

6 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (22)

Agam\AgaP_AGAP006379

12 of 12

Yes

Agam\AgaP_AGAP006380

12 of 12

Yes

Agam\AgaP_AGAP007504

12 of 12

Yes

Agam\AgaP_AGAP012155

12 of 12

Yes

Agam\AgaP_AGAP012156

12 of 12

Yes

Agam\AgaP_AGAP001523

7 of 12

Agam\AgaP_AGAP010416

4 of 12

Yes

4 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (49)

Atha\ABCA1

11 of 13

Yes

6 of 13

6 of 13

6 of 13

5 of 13

Yes

Atha\ABCA3

4 of 13

Yes

Atha\ABCA4

4 of 13

Yes

Atha\ABCA6

4 of 13

Yes

Atha\ABCA7

4 of 13

Yes

Atha\ABCA8

4 of 13

Yes

Atha\ABCA10

4 of 13

Yes

Atha\ABCA12

4 of 13

Yes

Atha\ABCI1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (19)

Scer\YOL075C

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\bfr1

1 of 12

Yes

Spom\hmt1

1 of 12

Yes

Spom\mam1

1 of 12

Yes

Spom\pdr1

1 of 12

Yes

Spom\pmd1

1 of 12

Yes

Escherichia coli (enterobacterium) (25)

Ecol\mglA

3 of 11

Yes

Ecol\ybhF

3 of 11

Yes

Ecol\yphE

3 of 11

Yes

Ecol\alsA

2 of 11

Ecol\araG

2 of 11

Yes

2 of 11

2 of 11

2 of 11

2 of 11

2 of 11

1 of 11

1 of 11

1 of 11

1 of 11

1 of 11

Yes

Ecol\hisP

1 of 11

Yes

1 of 11

1 of 11

1 of 11

1 of 11

Yes

Ecol\rbbA

1 of 11

Ecol\tcyN

1 of 11

Yes

Ecol\ybhR

1 of 11

Ecol\yehX

1 of 11

Yes

Ecol\yhdZ

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Abca3. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (24)

11 of 13

10 of 13

10 of 13

10 of 13

10 of 13

10 of 13

9 of 13

ldd

9 of 13

CG43672

6 of 13

CG11147

3 of 13

osy

3 of 13

snu

3 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

MRP

1 of 13

pix

1 of 13

rdog

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

autism spectrum disorder, susceptibility to (postulated), ABCA-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Abca3^GD3708

model of autism spectrum disorder

CEA

(Ueoka et al., 2020, Ueoka et al., 2018)

Abca3^HMS01796

model of autism spectrum disorder

CEA

(Ueoka et al., 2020, Ueoka et al., 2018)

Potential Models Based on Orthology ( 8 )

Human Ortholog

Disease

Evidence

References

ABCA3; ATP binding cassette subfamily A member 3

model of pulmonary alveolar proteinosis

IEA

(FlyBase, 2019-)

ABCA4; ATP binding cassette subfamily A member 4

model of Stargardt disease 1

IEA

(FlyBase, 2019-)

model of retinitis pigmentosa 19

IEA

(FlyBase, 2019-)

model of cone-rod dystrophy 3

IEA

(FlyBase, 2019-)

IEA

(FlyBase, 2019-)

ABCA7; ATP binding cassette subfamily A member 7

model of Alzheimer's disease 9

IEA

(FlyBase, 2019-)

ABCA1; ATP binding cassette subfamily A member 1

model of Tangier disease

IEA

(FlyBase, 2019-)

model of primary hypoalphalipoproteinemia 1

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Abca3^GD3708

model of autism spectrum disorder

is exacerbated by ena^HMS01953

(Ueoka et al., 2020)

is exacerbated by hpo^KC202

(Ueoka et al., 2020)

is exacerbated by hpo^KS240

(Ueoka et al., 2020)

is ameliorated by wts^x1

(Ueoka et al., 2020)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ABCA3; ATP binding cassette subfamily A member 3

14 of 14

601615

SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 3; SMDP3

pulmonary alveolar proteinosis

ABCA4; ATP binding cassette subfamily A member 4

8 of 14

601691

ABCA7; ATP binding cassette subfamily A member 7

8 of 14

605414

ALZHEIMER DISEASE 9, SUSCEPTIBILITY TO; AD9

Alzheimer's disease 9

ABCA1; ATP binding cassette subfamily A member 1

7 of 14

600046

ABCA2; ATP binding cassette subfamily A member 2

7 of 14

600047

INTELLECTUAL DEVELOPMENTAL DISORDER WITH POOR GROWTH AND WITH OR WITHOUT SEIZURES OR ATAXIA; IDPOGSA

ABCA12; ATP binding cassette subfamily A member 12

7 of 14

607800

ABCA6; ATP binding cassette subfamily A member 6

6 of 14

612504

ABCA8; ATP binding cassette subfamily A member 8

6 of 14

612505

ABCA9; ATP binding cassette subfamily A member 9

6 of 14

612507

ABCA10; ATP binding cassette subfamily A member 10

6 of 14

612508

ABCA13; ATP binding cassette subfamily A member 13

6 of 14

607807

ABCA5; ATP binding cassette subfamily A member 5

5 of 14

612503

HYPERTRICHOSIS, CONGENITAL GENERALIZED, 3, WITH OR WITHOUT GINGIVAL HYPERPLASIA; HTC3

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Abca3

enhanceable

hpo

(Ueoka et al., 2020)

Abca3

suppressible

hpo

(Ueoka et al., 2020)

Abca3

suppressible

wts

(Ueoka et al., 2020)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Eato

suppressible

Abca3

(Santoso et al., 2018)

Eato

enhanceable

Abca3

(Santoso et al., 2018)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0031170

MIST (protein-protein) - An integrated Molecular Interaction Database

33103

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

ABC transporters

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-65

Cytogenetic map

19F3-19F3

Sequence location

X:21,292,308..21,306,665 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

19F3-19F3

Limits computationally determined from genome sequence between P{EP}CG1702^EP1525 and P{EP}EP1465&P{EP}CG1486^EP1192

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-65

(FlyBase, 2016)

1-65.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

38353

y¹ v¹; P{TRiP.HMS01821}attP40

58885

w^* TI{TI}mir-1007^KO Abca3^mir-1007-KO

99987

y¹ w^* TI{CRIMIC.TG4.2}Abca3^{CR70819-TG4.2}

76565

y¹ sc^* v¹ sev²¹; P{TKO.GS01016}attP40

79728

y¹ sc^* v¹ sev²¹; P{TOE.GS01559}attP40

38329

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01796}attP2

11331

1718R-2

HMS01821

y¹ v¹; P{TRiP.HMS01821}attP40

VDRC

v105608

P{KK100452}VIE-260B

v44449

w¹¹¹⁸; P{GD3708}v44449

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (11)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0031170

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0031170

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Ueoka et al., 2018)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

One of the introns of CG1718 has the sequence and structural characteristics of a "mirtron"- mirtrons are encoded as an intron of another gene which accumulate as a lariats after splicing and require debranching enzyme for conversion into a functional miRNA. The mirtron encoded by the CG1718 intron is mir-1007.

(Ruby et al., 2007)

Nomenclature History

Source for database identify of

Source for identity of: Abca3 CG1718

(Ueoka et al., 2018)

Nomenclature comments

Etymology

FlyBase curator comment: Originally designated 'ABCA' but named as 'Abca3' in FlyBase because there are ten D. melanogaster genes encoding ABCA family members, and the authors state this one is most similar to human ABCA3.

(Ueoka et al., 2018)

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

ABCA

(Ramond et al., 2020, Schroeder et al., 2019, Ueoka et al., 2019)

ABCA3

(Soltani et al., 2025)

Abca3

(Xu et al., 2023, Gene Disruption Project members, 2018-)

DmCG1718

(He et al., 2019)

dABCA

(Ueoka et al., 2020, Ueoka et al., 2018)

Name Synonyms

ATP binding cassette subfamily A

ATP binding cassette subfamily A member 3

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 53 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33103

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

BI633799

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VRG4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VRG4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031170

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33103/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031170

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031170

FlyMine - An integrated database for Drosophila genomics

FBgn0031170

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1718

MARRVEL_MODEL - MARRVEL (model organism gene)

33103

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0031170

DroID - A comprehensive database of gene and protein interactions.

FBgn0031170

DRSC - Results frm RNAi screens

FBgn0031170

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031170

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0031170

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1718

Flygut - An atlas of the Drosophila adult midgut

FBgn0031170

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0031170

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

ABC transporters

MIST (protein-protein) - An integrated Molecular Interaction Database

33103

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (58)

The following external sites may use different assemblies or annotations than FlyBase.

-0.89

Report Sections