FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term ATPase-coupled transmembrane transporter activity ID (Ontology) GO:0042626 (Gene Ontology)
Definition Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.[ ISBN:0815340729 ]
Also Known As "ATP-coupled transmembrane transporter activity" ; "ATP-dependent transmembrane transporter activity" ; "ATPase activity, coupled to transmembrane movement of substances"
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      35
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 ATPase-coupled transmembrane transporter activity (all annotations which use CV term, excluding "NOT" statements)       4     35
     enables | ATPase-coupled transmembrane transporter activity       --      35
Spanning Tree (Parents/Children)
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molecular_function
 |__ATP-dependent activity_____________________________
active transmembrane transporter activity              |
 |__primary active transmembrane transporter activity__|
                                                       ATPase-coupled transmembrane transporter activity  123 rec.
                                                        |__ABC-type transporter activity 59 rec.
                                                        |   |__ABC-type 3',5'-cyclic GMP transmembrane transporter activity 1 rec.
                                                        |   |__ABC-type alkanesulfonate transporter transporter activity(+)
                                                        |   |__ABC-type amino acid transporter activity(+)
                                                        |   |__ABC-type azole transporter activity(+)
                                                        |   |__ABC-type betaine transporter activity
                                                        |   |__ABC-type bile acid transporter activity
                                                        |   |__ABC-type cadmium transporter activity
                                                        |   |__ABC-type capsular-polysaccharide transporter activity
                                                        |   |__ABC-type carbohydrate transporter activity(+)
                                                        |   |__ABC-type choline transporter activity
                                                        |   |__ABC-type doxorubicin transporter activity
                                                        |   |__ABC-type fatty-acyl-CoA transporter activity 1 rec.
                                                        |   |__ABC-type ferric hydroxamate transporter activity
                                                        |   |__ABC-type ferric iron transporter activity
                                                        |   |__ABC-type ferric-enterobactin transporter activity
                                                        |   |__ABC-type glutathione S-conjugate transporter activity
                                                        |   |__ABC-type glycerol-3-phosphate transporter activity
                                                        |   |__ABC-type guanine transporter activity 1 rec.
                                                        |   |__ABC-type heme transporter activity 3 rec.
                                                        |   |__ABC-type indole transporter activity
                                                        |   |__ABC-type iron-sulfur cluster transporter activity 1 rec.
                                                        |   |__ABC-type manganese transporter activity
                                                        |   |__ABC-type molybdate transporter activity
                                                        |   |__ABC-type nickel transporter activity
                                                        |   |__ABC-type nitrate transporter activity
                                                        |   |__ABC-type oligopeptide transporter activity 1 rec.
                                                        |   |__ABC-type peptide transporter activity(+)
                                                        |   |__ABC-type phosphonate transporter activity
                                                        |   |__ABC-type phytochelatin transporter activity
                                                        |   |__ABC-type polyamine transporter activity(+)
                                                        |   |__ABC-type protein transporter activity
                                                        |   |__ABC-type quaternary ammonium compound transporting activity(+)
                                                        |   |__ABC-type sodium transporter activity
                                                        |   |__ABC-type sterol transporter activity
                                                        |   |__ABC-type sulfate transporter activity
                                                        |   |__ABC-type teichoic acid transporter activity
                                                        |   |__ABC-type thiosulfate transporter activity
                                                        |   |__ABC-type tungstate transporter activity
                                                        |   |__ABC-type vitamin B12 transporter activity
                                                        |   |__ABC-type xenobiotic transporter activity(+) 5 rec.
                                                        |   |__ABC-type zinc transporter activity
                                                        |__ATPase-coupled 2-aminoethylphosphonate transporter activity
                                                        |__ATPase-coupled antimonite transmembrane transporter activity
                                                        |__ATPase-coupled arsenite transmembrane transporter activity
                                                        |__ATPase-coupled carboxylic acid transmembrane transporter activity
                                                        |   |__ABC-type capsular-polysaccharide transporter activity
                                                        |   |__ABC-type cysteine transporter activity
                                                        |   |__ABC-type D-methionine transporter activity
                                                        |   |__ATPase-coupled L-glutamine transmembrane transporter activity
                                                        |   |__ATPase-coupled monocarboxylic acid transmembrane transporter activity(+)
                                                        |__ATPase-coupled ion transmembrane transporter activity 37 rec.
                                                        |   |__ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(+) 37 rec.
                                                        |__ATPase-coupled lipid transmembrane transporter activity 1 rec.
                                                        |   |__ABC-type bile acid transporter activity
                                                        |   |__ABC-type fatty-acyl-CoA transporter activity 1 rec.
                                                        |   |__ABC-type sterol transporter activity
                                                        |__ATPase-coupled lipo-chitin oligosaccharide transmembrane transporter activity
                                                        |__ATPase-coupled monoatomic cation transmembrane transporter activity 52 rec.
                                                        |   |__ABC-type cadmium transporter activity
                                                        |   |__ABC-type ferric iron transporter activity
                                                        |   |__ABC-type manganese transporter activity
                                                        |   |__ABC-type nickel transporter activity
                                                        |   |__ABC-type sodium transporter activity
                                                        |   |__ABC-type zinc transporter activity
                                                        |   |__P-type cadmium transporter activity
                                                        |   |__P-type calcium transporter activity(+) 5 rec.
                                                        |   |__P-type cobalt transporter activity
                                                        |   |__P-type divalent copper transporter activity 1 rec.
                                                        |   |__P-type magnesium transporter activity 2 rec.
                                                        |   |__P-type manganese transporter activity 1 rec.
                                                        |   |__P-type monovalent copper transporter activity 1 rec.
                                                        |   |__P-type potassium transmembrane transporter activity(+) 4 rec.
                                                        |   |__P-type proton-exporting transporter activity(+)
                                                        |   |__P-type silver transporter activity
                                                        |   |__P-type sodium transporter activity(+) 4 rec.
                                                        |   |__P-type zinc transporter activity
                                                        |   |__proton-transporting ATPase activity, rotational mechanism 37 rec.
                                                        |   |__sodium-transporting ATPase activity, rotational mechanism
                                                        |__ATPase-coupled phosphate ion transmembrane transporter activity
                                                        |__ATPase-coupled urea transmembrane transporter activity
                                                        |__P-type transmembrane transporter activity 18 rec.
                                                        |   |__P-type ion transporter activity(+) 16 rec.
                                                        |__protein-transporting ATPase activity 5 rec.
                                                            |__ABC-type protein transporter activity
                                                            |__chloroplast protein-transporting ATPase activity
                                                            |__mitochondrial protein-transporting ATPase activity 2 rec.
                                                            |__protein-exporting ATPase activity
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Is a primary active transmembrane transporter activity
ATP-dependent activity
Part of
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Synonyms
  • "ATP-coupled transmembrane transporter activity" EXACT
    "ATP-dependent transmembrane transporter activity" EXACT
    "ATPase activity, coupled to movement of substances" BROAD
    "ATPase activity, coupled to transmembrane movement of substances" EXACT
    "hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances" NARROW
    "P-P-bond-hydrolysis-driven transmembrane transporter activity" BROAD
    "P-P-bond-hydrolysis-driven transporter" BROAD
Secondary IDs
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EC:7.2.2.-
Reactome:R-HSA-1467457 "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region"
Reactome:R-HSA-2161506 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate"
Reactome:R-HSA-2161538 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate"
Reactome:R-HSA-390393 "Peroxisomal uptake of very long-chain fatty acyl CoA"
Reactome:R-HSA-9033499 "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol"
Reactome:R-HSA-9033505 "PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12"
Reactome:R-HSA-9659680 "ABCB1 transports xenobiotics out of the cell"
Reactome:R-HSA-9750546 "ABCC4 transports TPMP substrates from cytosol to extracellular region"
Reactome:R-HSA-9750617 "ABCC5 transports TPMP substrates from cytosol to extracellular region"
Reactome:R-HSA-9753278 "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 "
Reactome:R-HSA-9753283 "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 "
Reactome:R-HSA-9753284 "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region"
Reactome:R-HSA-9759454 "ABCB1 transports PREDN,PREDL out of kidney cells"
Reactome:R-HSA-9759461 "ABCB1 transports PREDN,PREDL out of hepatic cells"
Reactome:R-HSA-9794120 "ABCG2 transports Cipro from intestinal cell to extracellular space"
Reactome:R-HSA-9794572 "ABCG2 transports Cipro from hepatic cell to extracellular space"