FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term ATP hydrolysis activity ID (Ontology) GO:0016887 (Gene Ontology)
Definition Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
Also Known As "adenosine 5'-triphosphatase activity" ; "adenosine triphosphatase activity" ; "adenosinetriphosphatase activity" (for all, see Synonyms field below)
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION     225
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 ATP hydrolysis activity (all annotations which use CV term, excluding "NOT" statements)      13    225
     contributes_to | ATP hydrolysis activity       --       4
     enables | ATP hydrolysis activity       --     224
 NOT | enables | ATP hydrolysis activity       --       4
Spanning Tree (Parents/Children)
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molecular_function
 |__ATP-dependent activity____________________________
pyrophosphatase activity                              |
 |__ribonucleoside triphosphate phosphatase activity__|
                                                      ATP hydrolysis activity  238 rec.
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Is a ribonucleoside triphosphate phosphatase activity
Part of ATP-dependent activity
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Synonyms
  • "adenosine 5'-triphosphatase activity" EXACT
    "adenosine triphosphatase activity" EXACT
    "adenosinetriphosphatase activity" EXACT
    "ATP hydrolase activity" EXACT
    "ATP monophosphatase activity" RELATED
    "ATP phosphohydrolase activity" EXACT
Secondary IDs
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Reactome:R-HSA-159101 "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)"
Reactome:R-HSA-3371422 "ATP hydrolysis by HSP70"
Reactome:R-HSA-416985 "Trafficking of GluR2-containing AMPA receptors to synapse"
Reactome:R-HSA-5618093 "ATP hydrolysis by HSP90"
Reactome:R-HSA-5654989 "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA"
Reactome:R-HSA-5694425 "NSF ATPase activity dissociates cis-SNARE"
Reactome:R-HSA-6809015 "NSF ATPase activity dissociates cis-SNARE at cis-Golgi"
Reactome:R-HSA-6811422 "NSF ATPase activity dissociates cis-SNARE at the ER"
Reactome:R-HSA-6814670 "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation"
Reactome:R-HSA-6814678 "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN"
Reactome:R-HSA-6814683 "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN"
Reactome:R-HSA-8847638 "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane"
Reactome:R-HSA-8868658 "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating"
Reactome:R-HSA-8939203 "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex"
Reactome:R-HSA-9038161 "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG"
Reactome:R-HSA-917693 "ESCRT Disassembly"
Reactome:R-HSA-9609860 "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP"
Reactome:R-HSA-9668415 "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope"
Reactome:R-HSA-9706399 "RHOBTB3 hydrolyzes ATP"
Reactome:R-HSA-9749350 "ATP-dependent release of CDT1 from the OCCM complex"
Reactome:R-HSA-9943614 "CHD2-dependent H3.3 deposition at MYOG gene"
Reactome:R-HSA-9944087 "CHD6-9-dependent ATP hydrolysis"
Reactome:R-HSA-9944091 "NuRD hydrolyzes ATP to affect nucleosome organization"
Reactome:R-HSA-9948300 "RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide"
Reactome:R-HSA-9949632 "VCP hexamer extracts K48 polyubiquitinated alanine-tailed nascent peptide from VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide"
Reactome:R-HSA-9955731 "ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide"
RHEA:13065