FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term ATP hydrolysis activity ID (Ontology) GO:0016887 (Gene Ontology)
Definition Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
Also Known As"adenosine 5'-triphosphatase activity" ; "adenosine triphosphatase activity" ; "adenosinetriphosphatase activity" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 ATP hydrolysis activity (all annotations which use CV term, excluding "NOT" statements)
     contributes_to | ATP hydrolysis activity       --
     enables | ATP hydrolysis activity       --
 NOT | enables | ATP hydrolysis activity       --
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molecular_function
 |__ATP-dependent activity____________________________
pyrophosphatase activity                              |
 |__ribonucleoside triphosphate phosphatase activity__|
                                                      ATP hydrolysis activity  258 rec.
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Is a ribonucleoside triphosphate phosphatase activity
Part of ATP-dependent activity
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Synonyms
  • "adenosine 5'-triphosphatase activity" EXACT
    "adenosine triphosphatase activity" EXACT
    "adenosinetriphosphatase activity" EXACT
    "ATP hydrolase activity" EXACT
    "ATP monophosphatase activity" RELATED
    "ATP phosphohydrolase activity" EXACT
Secondary IDs
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Reactome:R-HSA-159101 "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)"
Reactome:R-HSA-3371422 "ATP hydrolysis by HSP70"
Reactome:R-HSA-416985 "Trafficking of GluR2-containing AMPA receptors to synapse"
Reactome:R-HSA-5618093 "ATP hydrolysis by HSP90"
Reactome:R-HSA-5654989 "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA"
Reactome:R-HSA-5694425 "NSF ATPase activity dissociates cis-SNARE"
Reactome:R-HSA-6809015 "NSF ATPase activity dissociates cis-SNARE at cis-Golgi"
Reactome:R-HSA-6811422 "NSF ATPase activity dissociates cis-SNARE at the ER"
Reactome:R-HSA-6814670 "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation"
Reactome:R-HSA-6814678 "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN"
Reactome:R-HSA-6814683 "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN"
Reactome:R-HSA-8847638 "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane"
Reactome:R-HSA-8868658 "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating"
Reactome:R-HSA-8939203 "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex"
Reactome:R-HSA-9038161 "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG"
Reactome:R-HSA-917693 "ESCRT Disassembly"
Reactome:R-HSA-9609860 "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP"
Reactome:R-HSA-9668415 "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope"
Reactome:R-HSA-9706399 "RHOBTB3 hydrolyzes ATP"
Reactome:R-HSA-9749350 "ATP-dependent release of CDT1 from the OCCM complex"
Reactome:R-HSA-9948300 "RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide"
Reactome:R-HSA-9949632 "VCP hexamer extracts K48 polyubiquitinated alanine-tailed nascent peptide from VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide"
Reactome:R-HSA-9955731 "ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide"
RHEA:13065