FlyBase Allele Report: Dmel\wts[UAS.L.Tag:MYC]

General Information

Symbol

Dmel\wts^{UAS.L.Tag:MYC}

Species

D. melanogaster

Name

FlyBase ID

FBal0177117

Feature type

allele

Associated gene

Dmel\wts

Associated Insertion(s)

Carried in Construct

P{UAS-wts.L.MYC}

Also Known As

UAS-myc::wts, UAS-wts, UAS-Myc-Wts

Key Links

Transgenic product class

wild_type

(Lai et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Lai et al., 2005)

Mutagen

in vitro construct

(Lai et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-wts.L.MYC}

Cytology

Description

UASt sequences drive expression of wts tagged with Tag:MYC.

(Lai et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

wts

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by shot^GL01286

(Jain et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^en-e16E

(Boggiano et al., 2011)

abnormal size | adult stage, with Scer\GAL4^nub-AC-62

(Xu et al., 2018)

hypoplasia | adult stage, with Scer\GAL4^nub.PU

(Gaspar et al., 2015)

some die during P-stage, with Scer\GAL4^ey.PH

(Lai et al., 2005)

some die during pupal stage, with Scer\GAL4^ey.PH

(Lai et al., 2005)

visible | adult stage, with Scer\GAL4^en-e16E

(Boggiano et al., 2011)

visible | adult stage, with Scer\GAL4^nub.PU

(Gaspar et al., 2015)

visible | adult stage, with Scer\GAL4^nub-AC-62

(Xu et al., 2018)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PH

(Lai et al., 2005)

eye disc, with Scer\GAL4^ey.PH

(Lai et al., 2005)

wing, with Scer\GAL4^en-e16E

(Boggiano et al., 2011)

wing, with Scer\GAL4^nub-AC-62

(Xu et al., 2018)

wing blade, with Scer\GAL4^nub.PU

(Gaspar et al., 2015)

Detailed Description

Statement

Reference

Adults expressing wts^{UAS.L.Tag:MYC} under the control of Scer\GAL4^nub-AC-62 display significantly smaller wings, as compared to controls.

(Xu et al., 2018)

Ectopic expression of wts^{Scer\UAS.L.T:Hsap\MYC} under the control of Scer\GAL4^nub.PU results in severely undergrown wings in adult flies.

(Gaspar et al., 2015)

The wings of flies expressing wts^{Scer\UAS.L.T:Hsap\MYC} under the control of Scer\GAL4^en-e16E appear under-proliferated, having smaller posterior compartments compared to controls.

(Boggiano et al., 2011)

When wts^{Scer\UAS.L.T:Hsap\MYC} is driven by Scer\GAL4^ey.PH both the larval eye disc and the adult eye are smaller than normal. About 20% of animals die in the late pupa stage.

(Lai et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^ey.PH, wts^{UAS.L.Tag:MYC} has some die during P-stage phenotype, enhanceable by mats^UAS.cLa/Scer\GAL4^ey.PH

(Lai et al., 2005)

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, wts^{UAS.L.Tag:MYC} has visible | adult stage phenotype, suppressible | partially by Scer\GAL4^en-e16E/Tao^GD8262

(Boggiano et al., 2011)

Scer\GAL4^en-e16E, wts^{UAS.L.Tag:MYC} has abnormal size | adult stage phenotype, suppressible | partially by Scer\GAL4^en-e16E/Tao^GD8262

(Boggiano et al., 2011)

NOT suppressed by

Statement

Reference

Scer\GAL4^nub-AC-62, wts^{UAS.L.Tag:MYC} has abnormal size | adult stage phenotype, non-suppressible by Scer\GAL4^nub-AC-62/yki^{UAS.Tag:FLAG,Tag:Myr(Src64B)}

(Xu et al., 2018)

Scer\GAL4^nub.PU, wts^{UAS.L.Tag:MYC} has visible | adult stage phenotype, non-suppressible by Scer\GAL4^nub.PU/Zyx^UAS.cGa

(Gaspar et al., 2015)

Scer\GAL4^nub.PU, wts^{UAS.L.Tag:MYC} has hypoplasia | adult stage phenotype, non-suppressible by Scer\GAL4^nub.PU/Zyx^UAS.cGa

(Gaspar et al., 2015)

Suppressor of

Statement

Reference

Scer\GAL4^en-e16E/wts^{UAS.L.Tag:MYC} is a suppressor | partially of lethal phenotype of Scer\GAL4^en-e16E, Tao^GD8262

(Boggiano et al., 2011)

NOT Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/wts^{UAS.L.Tag:MYC} is a non-suppressor of abnormal neuroanatomy phenotype of hpo^MGH4

(Emoto et al., 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^ey.PH, wts^{UAS.L.Tag:MYC} has eye phenotype, enhanceable by mats^UAS.cLa/Scer\GAL4^ey.PH

(Lai et al., 2005)

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, wts^{UAS.L.Tag:MYC} has wing phenotype, suppressible | partially by Scer\GAL4^en-e16E/Tao^GD8262

(Boggiano et al., 2011)

NOT suppressed by

Statement

Reference

Scer\GAL4^nub-AC-62, wts^{UAS.L.Tag:MYC} has wing phenotype, non-suppressible by Scer\GAL4^nub-AC-62/yki^{UAS.Tag:FLAG,Tag:Myr(Src64B)}

(Xu et al., 2018)

Scer\GAL4^nub.PU, wts^{UAS.L.Tag:MYC} has wing blade phenotype, non-suppressible by Scer\GAL4^nub.PU/Zyx^UAS.cGa

(Gaspar et al., 2015)

NOT Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/wts^{UAS.L.Tag:MYC} is a non-suppressor of multidendritic dendrite phenotype of hpo^MGH4

(Emoto et al., 2006)

Other

Statement

Reference

Scer\GAL4^ey.PH, mats^UAS.cLa, wts^{UAS.L.Tag:MYC} has eye phenotype

(Lai et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The severely undergrown wing phenotype seen in adult flies expressing wts^{Scer\UAS.L.T:Hsap\MYC} under the control of Scer\GAL4^nub.PU cannot be alleviated by co-expression of Zyx^Scer\UAS.cGa.

(Gaspar et al., 2015)

Expression of wts^{Scer\UAS.L.T:Hsap\MYC} partially suppresses the lethality seen when Tao^GD8262 is expressed under the control of Scer\GAL4^en-e16E.

Expression of Tao^GD8262 partially suppresses the wing under-proliferation seen when wts^{Scer\UAS.L.T:Hsap\MYC} is expressed under the control of Scer\GAL4^en-e16E.

(Boggiano et al., 2011)

When both wts^{Scer\UAS.L.T:Hsap\MYC} and mats^Scer\UAS.cLa are driven in the eye (by Scer\GAL4^GMR.PF) eyes are even smaller than when Scer\GAL4^ey.PH is expressed alone and have a cone shape. About 70% of animals exhibit a late pupal lethal; phenotype.

(Lai et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

wts^{UAS.L.Tag:MYC}/Scer\GAL4^ppk.PG rescues wts^P1

(Emoto et al., 2006)

Comments

Expression of wts^{Scer\UAS.L.T:Hsap\MYC}, under the control of Scer\GAL4^ppk.PG largely rescues the dendritic phenotype of wts^P1.

(Emoto et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

600512

w^*; P{UAS-wts.L.MYC}2/CyO, P{Dfd-EYFP.w^BmC}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

wts^{Scer\UAS.L.T:Hsap\MYC}

wts^{UAS.L.Tag:MYC}

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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