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FB2026_01
,
released March 12, 2026
l(2)09373, dMRCK, Genghis Kahn
similar to myotonic dystrophy protein kinase - regulates cytoskeletal dynamics - GTPase effector that is required for columnar target specificity in the Drosophila visual system
Please see the JBrowse view of Dmel\gek for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.52
5.1 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
1613 (aa)
Interacts tightly with GTP-bound but not GDP-bound Cdc42.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\gek using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
In third instar larvare, gek protein is observed in R cell axons extending to the lamina, in growth cones within the lamina plexus, as well as within the medulla neuropil. Weak staining is seen in the R cell bodies in the eye disc. Early in pupal development (16hr APF), gek is strongly expressed in R cell axons in both the lamina and the medulla. At 30hr APF, gek is strongly expressed on R1-R6 growth cones within the lamina plexus, and is also expressed in many other neurons in the optic ganglia.
JBrowse - Visual display of RNA-Seq signals
View Dmel\gek in JBrowse2-106
2-109.9
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a whole range of mitotic abnormalities, abnormal spindles and chromosome alignment defects are seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
Area matching Drosophila ESTS AI820473 and AA820473 (inverted). Sequence similarity putative cytochrome bc-1 complex core protein <up>Haematobia irritans irritans</up>.
Identification: On the basis of physical interaction with Cdc42.
Egg chambers homozygous for gek mutations exhibit abnormal accumulation of F-actin structures and are defective in producing fertilized eggs.
Germ-line clonal analysis suggests gek function is essential for proper oogenesis.
The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. gek gene expression during oogenesis is not critical to embryonic development, but the gene function may be essential for fertilisation and/or completion of meiosis.
Source for merge of: gek Mrck
Source for merge of: gek MdaPk
Source for identity of: gek CG4012
The gene is named after the powerful Mongolian emperor Genghis Khan due to the phenotype of ectopic F-actin accumulation. The symbol, "gek", also stands for "GTPase effector kinase".
