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General Information
Symbol
EBV\BRLF1GMR.PA
Species
L. Cercopithecine herpesvirus 15
Name
glass multimer reporter construct of Adamson
FlyBase ID
FBal0297399
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
GMR-R
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

GMR regulatory sequences drive expression of a EBV\BRLF1 cDNA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies expressing EBV\BRLF1GMR.PA display rough eyes and extra small bristles.

Expression of EBV\BRLF1GMR.PA results in a rough adult eye phenotype. While wild-type eyes have an organized pattern of ommatidia, the flies expressing EBV\BRLF1GMR.PA show unorganized ommatidial and bristle structure. The eye-phenotype is dose sensitive: the higher the dose, the more severe the phenotype is.

In EBV\BRLF1GMR.PA eye discs, more mitotic cells are found in the morphogenetic furrow as well as more mitotic cells posterior to the furrow. EBV\BRLF1GMR.PA discs have on average 1.5 times more cells in mitosis than wild-type discs. Overproliferation is also evident in EBV\BRLF1GMR.PA adult eyes. Some ommatidia contain an extra photoreceptor cell. The eyes of the mutants also show an overabundance of pigment granules, which contributes to the darker adult eye color is these flies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

EBV\BRLF1GMR.PA has eye phenotype, enhanceable by brat1

EBV\BRLF1GMR.PA has eye phenotype, enhanceable by Mer4

Suppressed by
Statement
Reference

EBV\BRLF1GMR.PA has eye phenotype, suppressible | partially by Tor[+]/TorΔP

EBV\BRLF1GMR.PA has ommatidium phenotype, suppressible | partially by Tor[+]/TorΔP

EBV\BRLF1GMR.PA has eye phenotype, suppressible | partially by Tor[+]/Tork17004

EBV\BRLF1GMR.PA has ommatidium phenotype, suppressible | partially by Tor[+]/Tork17004

EBV\BRLF1GMR.PA has eye phenotype, suppressible by TorΔP

Other
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

While EBV\BZLF1GMR.PA expression alone does not significantly alter the number of mitotic cells in eye discs, expression of EBV\BZLF1GMR.PA reverses the EBV\BRLF1GMR.PA overproliferation, such that the number of mitotic cells is lower than in wild-type controls. The number of short hair-like bristles in the adult eye is also decreased. The eye color of the double-transgenic flies is very similar to that of single-transgenic EBV\BZLF1GMR.PA flies (orange), suggesting that pigment cells do not over-proliferate as in EBV\BRLF1GMR.PA-eyes. The double-transgenic flies show a complete loss of ommatidia, although the bristles remain.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
EBV\BRLF1GMR.PA
Name Synonyms
glass multimer reporter construct of Adamson
Secondary FlyBase IDs
    References (2)