FlyBase Allele Report: Dmel\mTor[k17004]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\mTor^k17004

General Information

Symbol

Dmel\mTor^k17004

Species

D. melanogaster

Name

FlyBase ID

FBal0064028

Feature type

allele

Associated gene

Associated Insertion(s)

P{lacW}mTor^k17004

Carried in Construct

Also Known As

Tor^K17004, dTOR^P1

Key Links

Genomic Maps

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}mTor^k17004

Cytology

Description

The P{lacW} insertion is located 211bp upstream of the putative translation start of Tor, and within the 5' UTR.

(Oldham et al., 2000)

The P{lacW} insertion is located 24bp downstream of the transcription start site.

(Zhang et al., 2000)

Allele components

Component

Use(s)

Inserted element

Encoded product / tool

reporter enzyme

Tagged with

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:13,004,311..13,004,659 [+]

(Xu et al., 2017, Adamson et al., 2014, Adamson and Lajeunesse, 2012, Kim et al., 2010, Parrish et al., 2009, Zhang et al., 2006, Oldham et al., 2000, Zhang et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates viral infectious disease

modeled by EBV\BRLF1^GMR.PA

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

exacerbates viral infectious disease

modeled by EBV\BZLF1^GMR.PA

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

ameliorates infectious mononucleosis

modeled by EBV\BRLF1^GMR.PA

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

exacerbates infectious mononucleosis

modeled by EBV\BZLF1^GMR.PA

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

ameliorates Epstein-Barr virus hepatitis

modeled by EBV\BRLF1^GMR.PA

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

exacerbates Epstein-Barr virus hepatitis

modeled by EBV\BZLF1^GMR.PA

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

ameliorates hereditary spastic paraplegia 3A

modeled by atl^RNAi.UAS

(Xu et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

dendrite | adult stage | somatic clone

(Luo et al., 2020)

distal medullary amacrine neuron Dm8a | adult stage | somatic clone

(Luo et al., 2020)

(Ballard et al., 2010)

fat body | second instar larval stage

(Lee et al., 2007)

(Zhang et al., 2000)

larval salivary gland & nucleus (with mTor^2L1)

(Oldham et al., 2000)

(Lee et al., 2007)

spermatocyte (with mTor^A948V)

(Azuma et al., 2021)

(Lee et al., 2007)

Detailed Description

Statement

Reference

Tor^k17004/Tor^k17004 larvae show a severe growth defect and are smaller in size than control larvae.

Tor^k17004/+ larvae develop normally.

(Schmitt et al., 2015)

Tor^k17004/+ flies have eyes similar to wild-type.

(Adamson et al., 2014)

The body mass of third instar larvae is reduced for homozygous Tor^k17004 mutants.

Homozygous Tor^k17004 mutant third instar larvae show increased uptake and transport of ingested fluorescently labeled fatty acids from the midgut lumen to the fat body compared to wild-type controls.

(Ballard et al., 2010)

Mutant flies fed a high-fat diet do not show an increase in triglyceride levels, in contrast to wild-type controls fed this diet.

Mutant flies have impaired geotaxic ability when fed a normal food diet, and this phenotype is exacerbated on a high-fat diet.

Mutant flies show considerable protection against deterioration of heart function compared to controls when placed on a high-fat diet. The mutant flies have unchanged heartbeat and contractility parameters on a normal food diet and on a high-fat diet, which are comparable to the values seen in wild-type flies on a normal food diet. The incidences of conduction blocks, dysfunctional ostia and non-contractile myocardial regions are as low in the mutant flies under normal food or high-fat diet conditions as in wild-type flies on a normal food diet. Myocardial structure remains intact in the mutant flies under a high-fat diet.

(Birse et al., 2010)

Tor^k17004 homozygous animals show growth arrest in the second/early third instar larval stages, and markedly delayed growth.

Tor^k17004 homozygous animals show lipid vesicle aggregation in the fat body of second/early third instar larvae.

Cell and nuclear size of the salivary gland cells are markedly reduced in Tor^k17004 larvae.

(Lee et al., 2007)

Tor^2L1/Tor^k17004 mutants have wing discs that are approximately wild-type in size. The size of the nuclei in the endoreplicating salivary glands are smaller than wild-type.

(Oldham et al., 2000)

Homozygotes hatch at normal rates, but grow more slowly than normal and eventually arrest during larval development, reaching only 40% the mass of wild-type controls. The mutants remain viable and active during an extended larval period of about 30 days and eventually die without pupating.

(Zhang et al., 2000)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

mTor^k17004 has abnormal body size | second instar larval stage phenotype, suppressible by Atg1[+]/Atg1^Δ3D

(Lee et al., 2007)

mTor^k17004 has abnormal body size | second instar larval stage phenotype, suppressible by Atg1^EP3348/Atg1^EP3348

(Lee et al., 2007)

mTor^k17004 has abnormal body size | second instar larval stage phenotype, suppressible by Atg1^Δ3D/Atg1^Δ3D

(Lee et al., 2007)

mTor^k17004 has lethal phenotype, suppressible | partially by Atg1^EP3348/Atg1^EP3348

(Lee et al., 2007)

mTor^k17004 has lethal phenotype, suppressible | partially by Atg1^Δ3D/Atg1^Δ3D

(Lee et al., 2007)

mTor^k17004 has decreased cell size phenotype, suppressible | partially by Atg1[+]/Atg1^EP3348

(Lee et al., 2007)

mTor^k17004 has decreased cell size phenotype, suppressible | partially by Atg1[+]/Atg1^Δ3D

(Lee et al., 2007)

mTor^k17004 has abnormal body size | second instar larval stage phenotype, suppressible by Atg1[+]/Atg1^EP3348

(Lee et al., 2007)

mTor^EP2353/mTor^k17004 has lethal phenotype, suppressible by S6k^UAS.cWa/Scer\GAL4^Act5C.PP

(Zhang et al., 2000)

mTor^EP2353/mTor^k17004 has lethal phenotype, suppressible by Hsap\RPS6KB1^D4.UAS/Scer\GAL4^Act5C.PP

(Zhang et al., 2000)

Enhancer of

Statement

Reference

Tor[+]/mTor^k17004 is an enhancer of some die during P-stage | heat sensitive phenotype of Lpin^RNAi.hs

(Schmitt et al., 2015)

Suppressor of

Statement

Reference

mTor^k17004 is a suppressor | partially of visible phenotype of Dcp-1^UAS.cKa, Scer\GAL4^GMR.PF

(Kim et al., 2010)

NOT Suppressor of

Statement

Reference

Tor[+]/mTor^k17004 is a non-suppressor of lethal | larval stage phenotype of gig¹⁹³/gig¹⁰⁹

(Zhang et al., 2006)

Other

Statement

Reference

Lpin^RNAi.hs, Tor[+]/mTor^k17004 has visible | larval stage | heat sensitive phenotype

(Schmitt et al., 2015)

Lpin^RNAi.hs, Tor[+]/mTor^k17004 has abnormal size | larval stage | heat sensitive phenotype

(Schmitt et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

mTor^k17004 has fat body | second instar larval stage phenotype, suppressible by Atg1[+]/Atg1^EP3348

(Lee et al., 2007)

mTor^k17004 has fat body | second instar larval stage phenotype, suppressible by Atg1[+]/Atg1^Δ3D

(Lee et al., 2007)

mTor^k17004 has vesicle phenotype, suppressible by Atg1[+]/Atg1^EP3348

(Lee et al., 2007)

mTor^k17004 has vesicle phenotype, suppressible by Atg1[+]/Atg1^Δ3D

(Lee et al., 2007)

mTor^k17004 has nucleus phenotype, suppressible | partially by Atg1[+]/Atg1^EP3348

(Lee et al., 2007)

mTor^k17004 has nucleus phenotype, suppressible | partially by Atg1[+]/Atg1^Δ3D

(Lee et al., 2007)

Enhancer of

Statement

Reference

Tor[+]/mTor^k17004 is an enhancer of eye phenotype of EBV\BZLF1^GMR.PA

(Adamson et al., 2014)

mTor^k17004 is an enhancer of eye phenotype of EBV\BZLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

NOT Enhancer of

Statement

Reference

Tor[+]/mTor^k17004 is a non-enhancer of lipid droplet | larval stage | heat sensitive phenotype of Lpin^RNAi.hs

(Schmitt et al., 2015)

Suppressor of

Statement

Reference

Tor[+]/mTor^k17004 is a suppressor | partially of eye phenotype of EBV\BRLF1^GMR.PA

(Adamson et al., 2014)

Tor[+]/mTor^k17004 is a suppressor | partially of interommatidial bristle phenotype of EBV\BRLF1^GMR.PA

(Adamson et al., 2014)

Tor[+]/mTor^k17004 is a suppressor | partially of ommatidium phenotype of EBV\BRLF1^GMR.PA

(Adamson et al., 2014)

mTor^k17004 is a suppressor of eye phenotype of EBV\BRLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

mTor^k17004 is a suppressor | partially of eye phenotype of Dcp-1^UAS.cKa, Scer\GAL4^GMR.PF

(Kim et al., 2010)

Other

Statement

Reference

Lpin^RNAi.hs, Tor[+]/mTor^k17004 has embryonic/larval fat body | larval stage | heat sensitive phenotype

(Schmitt et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Tor^k17004/+ in larvae expressing Lpin^dsRNA.hs (induced by heat shock) leads to a reduction in fat body mass and a transparent appearance of larvae; an increase in pupal lethality as compared to larvae expressing Lpin^dsRNA.hs in a wild type background; and the fat bodies from these larvae are smaller; but lipid droplets in the fat bodies of these larvae exhibit a similar size reduction as those in larvae expressing Lpin^dsRNA.hs in a wild type background.

(Schmitt et al., 2015)

Tor^k17004 partially suppresses the rough eye phenotype seen when Dcp-1^Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4^GMR.PF.

(Kim et al., 2010)

Tor^k17004 homozygous animals in a heterozygous Atg1^EP3348 or Atg1^Δ3D genetic background grow faster, and extend their developmental stage to mid/late third instar larval stage. Double homozygous animals survive to mid-late third instar larval stage.

Lipid vesicle aggregation in the fat body of Tor^k17004 homozygous second/early third instar larvae is suppressed in a heterozygous Atg1^EP3348 or Atg1^Δ3D genetic background.

Tor^k17004 mutant larvae heterozygous for Atg1^EP3348 or Atg1^Δ3D show a partially rescued cell and nuclear salivary gland size.

(Lee et al., 2007)

Xenogenetic Interactions

Statement

Reference

Tor^k17004/+ partially suppresses the eye-phenotype associated with EBV\BRLF1^GMR.PA-expression.

Tor^k17004/+ partially enhances the eye-phenotype associated with EBV\BRLF1^GMR.PA-expression.

(Adamson et al., 2014)

Complementation and Rescue Data

Fails to complement

(Oldham et al., 2000)

(Oldham et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

11218

y¹ w^67c23; P{lacW}mTor^k17004/CyO

111369

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{lacW}mTor^k17004 P{neoFRT}40A/CyO y⁺

Notes on Origin

Discoverer

I. Kiss.

(BDGP Project Members, 1994-1999)

Comments

Comments

Complements: Vha68-2^k02508. Complements: l(2)k07015^k07015. Complements: l(2)k07332^k07332. Complements: Vha68-2^k07404.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

TOR^7/P

(Birse et al., 2010)

TOR^P

(Diop et al., 2015)

TOR^k17004

(Schmitt et al., 2015, Khurana et al., 2006)

Tor^K17004

(Walker et al., 2006)

Tor^k17004

(Azuma et al., 2021, Luo et al., 2020, Xu et al., 2017, Adamson et al., 2014, Adamson and Lajeunesse, 2012, Ballard et al., 2010)

dTOR^P1

(Zhang et al., 2000)

dTor^P1

(Lee et al., 2007)

l(2)k17004

(Spradling et al., 1999)

l(2)k17004^k17004

(BDGP Project Members, 1994-1999)

mTor^k17004

Name Synonyms

Secondary FlyBase IDs

References (19)

Report Sections