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General Information
Symbol
Dmel\Tor2L19
Species
D. melanogaster
Name
FlyBase ID
FBal0120584
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C13005725T

Amino acid change:

R248term | Tor-PA; R248term | Tor-PB

Reported amino acid change:

R248term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: R248term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Tor2L19 mutant clones generated in otherwise wild-type eyes are massively under-represented. The adult eyes are almost completely composed of wild-type twin clone tissue.

Central nervous system neuroblasts of mutant fed early second instar larvae show a reduction in EdU incorporation compared to controls.

Tissue specific induction of Tor2L19 mutant clones in the head produces flies with reduced head size relative to the body.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Suppressed by
Statement
Reference
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

Tor2L19 is a suppressor of increased cell growth phenotype of Pten117

Phenotype Manifest In
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

Tor2L19 is a suppressor of eye phenotype of Pten117

Additional Comments
Genetic Interactions
Statement
Reference

REPTORKO significantly rescues both the metabolic and size phenotypes of Tor2L1/Tor2L19 larvae.

Eyes mutant for Pten117 and Tor2L19 are reduced to the size of control eyes at both fed and starved conditions, indicating that the overgrowth of Pten117 clones depends on normal TORC1 function.

The generation of Pten117 and Tor2L19 sister clones results in eyes that are completely composed of Pten mutant tissue. However, these eyes are smaller than those without Tor2L19 mutant sister clones.

Ubiquitous expression of ImpL2Scer\UAS.cHa (under the control of Scer\GAL4Act5C.PP) results in the overgrowth of Pten117 clones, irrespective of whether they neighbor Tor2L19 mutant or wild-type cells. The overgrowth of Pten117 clones causes a further reduction in body size, as evidenced by decreased shoulder width.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (10)