visible | adult stage, with Scer\GAL4GMR.PFa
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PFa
Expression of DroncS130A.UAS.cSa under the control of Scer\GAL4GMR.PFa results in a strong eye depigmentation phenotype adult flies (vast majority of photoreceptors are without pigment).
Overexpression of Dcp-1Scer\UAS.cKa under the control of Scer\GAL4GMR.PF induces a marked increase in the number of caspase-3-positive puncta compared with wild-type eye discs, indicating an increase in cell death.
Expression of Dcp-1Scer\UAS.cKa under the control of Scer\GAL4elav-C155 results in severe motoneuron degeneration. Axons have a narrower caliber and there is clear evidence of axonal breaks and fragmentation, as well as degeneration at the nerve terminal. Synaptic transmission is also severely disrupted. Expression of Dcp-1Scer\UAS.cKa in single motorneuron axons using Scer\GAL4eve.RRa shows that the axonal degeneration does not spread to adjacent wild type axons innervating the same muscle target, and nor do these axons undergo any compensatory growth. No neuronal sprouting is seen at sites of broken axons and TUNEL assays show that motorneuron cell death is occurring. Expression of Dcp-1Scer\UAS.cKa in the glia under the control of Scer\GAL4egr-GAL4 has no effect on motorneuron degeneration.
Flies expressing Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) under the control of Scer\GAL4GMR.PF display a modest rough eye phenotype. This rough eye phenotype is also seen in the P{UAS-Dcp-1.K}1-2, P{UAS-Dcp-1.K}2-4, P{UAS-Dcp-1.K}4-1 P{UAS-Dcp-1.K}5-4 and P{UAS-Dcp-1.K}7-3 insertion lines. Flies carrying two copies of P{UAS-Dcp-1.K}19-2 and Scer\GAL4GMR.PF display a much more severe eye phenotype. These flies are semi-lethal and have a short lifespan.
The insertion lines P{UAS-Dcp-1.K}1-1, P{UAS-Dcp-1.K}1-2, P{UAS-Dcp-1.K}1-4, P{UAS-Dcp-1.K}1-5, P{UAS-Dcp-1.K}2-4 and P{UAS-Dcp-1.K}4-1 show male pupal lethality.
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by DeltaDN.UAS, Scer\GAL4GMR.PF
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by AktUAS.Tag:HA, Scer\GAL4GMR.PF
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by Pi3K92EUAS.Tag:MYC, Scer\GAL4GMR.PF
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by Eip74EFG15347
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by brG1972
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by Eip78CG14526
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by psqG7540
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by Ubc4G4874
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by Uba1G3534
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by Uba2G6571
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by EgfrUAS.cBa, Scer\GAL4GMR.PF
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by CthG2166
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by esgEP2009
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by Uba2G8583
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by bchsG12113
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by bchsG13044
Dcp-1UAS.cKa, Scer\GAL4GMR.PFa has visible | adult stage phenotype, suppressible by DarkKK104215, Scer\GAL4GMR.PFa
Dcp-1UAS.cKa, Scer\GAL4GMR.PFa has abnormal eye color phenotype, suppressible by DarkKK104215, Scer\GAL4GMR.PFa
Dcp-1UAS.cKa, Scer\GAL4GMR.PFa has visible | adult stage phenotype, suppressible | partially by Usp15-31KK101035, Scer\GAL4GMR.PFa
Dcp-1UAS.cKa, Scer\GAL4GMR.PFa has abnormal eye color phenotype, suppressible | partially by Usp15-31KK101035, Scer\GAL4GMR.PFa
Dcp-1UAS.cKa, Scer\GAL4GMR.PFa has visible | adult stage phenotype, suppressible | partially by Usp15-31KG04149/Usp15-31[+]
Dcp-1UAS.cKa, Scer\GAL4GMR.PFa has abnormal eye color phenotype, suppressible | partially by Usp15-31KG04149/Usp15-31[+]
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by Diap1EP3279
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by Atg2G6691
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by Atg6G6854
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by Atg1G13748
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by Atg3G3894
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by S6kUAS.cMa, Scer\GAL4GMR.PF
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible | partially by mTork17004
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by SNF4AγGX6409
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by CthG13564
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by brG10174
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by Usp47G5032
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by Uba2G4384
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by fafEP3520
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by effG15069
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by bchsG2362
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible | partially by Atg4aG18114
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible | partially by Atg6G3772
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible | partially by Atg7G8010
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by Atg8aG9749
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by Atg18aG3744
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by aopEP598
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by Usp47G5401
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has visible phenotype, suppressible by BacA\p35UAS.cHa, Scer\GAL4GMR.PF
Dcp-1UAS.cKa, Scer\GAL4GMR.PFa has visible | adult stage phenotype, non-suppressible by Usp39NIG.7288R, Scer\GAL4GMR.PFa
Dcp-1UAS.cKa, Scer\GAL4GMR.PFa has abnormal eye color phenotype, non-suppressible by Usp39NIG.7288R, Scer\GAL4GMR.PFa
Dcp-1UAS.cKa, PtenUAS.cGa, Scer\GAL4GMR.PF has lethal phenotype
Dcp-1UAS.cKa, Rac1N17.UAS, Scer\GAL4GMR.PF has lethal phenotype
Dcp-1UAS.cKa, Scer\GAL4GMR.PF, bskDN.UAS has lethal phenotype
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by DeltaDN.UAS, Scer\GAL4GMR.PF
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by bchsG13044
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by AktUAS.Tag:HA, Scer\GAL4GMR.PF
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by Pi3K92EUAS.Tag:MYC, Scer\GAL4GMR.PF
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by Eip74EFG15347
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by brG1972
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by Eip78CG14526
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by Ubc4G4874
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by Uba1G3534
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by Uba2G6571
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by EgfrUAS.cBa, Scer\GAL4GMR.PF
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by psqG7540
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by CthG2166
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by esgEP2009
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by bchsG12113
Dcp-1UAS.cKa, Scer\GAL4GMR.PFa has eye phenotype, suppressible by DarkKK104215, Scer\GAL4GMR.PFa
Dcp-1UAS.cKa, Scer\GAL4GMR.PFa has eye phenotype, suppressible | partially by Usp15-31KK101035, Scer\GAL4GMR.PFa
Dcp-1UAS.cKa, Scer\GAL4GMR.PFa has eye phenotype, suppressible | partially by Usp15-31KG04149/Usp15-31[+]
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by SNF4AγGX6409
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by CthG13564
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by brG10174
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Usp47G5032
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Uba2G4384
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by fafEP3520
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by effG15069
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by bchsG2362
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible | partially by Atg4aG18114
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible | partially by Atg6G3772
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible | partially by Atg7G8010
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Atg8aG9749
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Atg18aG3744
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by aopEP598
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Usp47G5401
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by BacA\p35UAS.cHa, Scer\GAL4GMR.PF
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Diap1EP3279
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Atg2G6691
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Atg6G6854
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Atg1G13748
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Atg3G3894
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible by S6kUAS.cMa, Scer\GAL4GMR.PF
Dcp-1UAS.cKa, Scer\GAL4GMR.PF has eye phenotype, suppressible | partially by mTork17004
Dcp-1UAS.cKa, Scer\GAL4GMR.PFa has eye phenotype, non-suppressible by Usp39NIG.7288R, Scer\GAL4GMR.PFa
The eye depigmentation phenotype characteristic for adult flies expressing Dcp-1UAS.cKa under the control of Scer\GAL4GMR.PFa is significantly improved by expression of DarkKK104215 and to a lesser extent by Usp15-31KK101035 or by combination with a single copy of Usp15-31KG04149, whereas co-expression of Usp39NIG.7288R fails to affect the phenotype.
Expression of thEP3279 suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Atg2G6691 suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Atg6G6854 suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Atg1G13748 suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Aut1G3894 suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Expression of S6kScer\UAS.cMa suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Tork17004 partially suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
SNF4AγGX6409 suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Eip55EG13564 suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
brG10174 suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Ubp64EG5032 suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Uba2G4384 suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
fafEP3520 enhances the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
effG15069 enhances the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
bchsG12113 enhances the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
bchsG13044 enhances the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
bchsG2362 suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Atg4G18114 partially suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Atg6G3772 partially suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Atg7G8010 partially suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Atg8aG9749 suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Atg18G3744 suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Expression of Akt1Scer\UAS.T:Ivir\HA1 enhances the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Expression of Pi3K92EScer\UAS.T:Hsap\MYC enhances the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Co-expression of PtenScer\UAS.cGa and Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) under the control of Scer\GAL4GMR.PF is lethal.
Co-expression of bskDN.Scer\UAS and Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) under the control of Scer\GAL4GMR.PF is lethal.
aopEP598 suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Eip74EFG15347 enhances the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Eip55EG2166 enhances the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
brG1972 enhances the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Eip78CG14526 enhances the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Ubp64EG5032 suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Ubp64EG5401 suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
UbcD4G4874 enhances the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Uba1G3534 enhances the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Uba2G6571 enhances the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Uba2G8583 enhances the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Expression of EgfrScer\UAS.cBa enhances the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Expression of DlD.Scer\UAS enhances the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
psqG7540 enhances the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
esgEP2009 enhances the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.
Expression of BacA\p35Scer\UAS.cHa suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.