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General Information
Symbol
Dmel\S6kUAS.cMa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Montagne
FlyBase ID
FBal0103997
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-dS6K, UAS-S6k
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS sequences drive S6k expression.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of S6kScer\UAS.cMa under the control of Scer\GAL4da.G32 results in an increase in larval body weight compared to controls.

Overexpression of S6kScer\UAS.cMa under the control of Scer\GAL4GMR.PF, does not induce autophagy in developing eye discs.

Overexpression of S6kScer\UAS.cMa in the developing eye, under the control of Scer\GAL4GMR.PF, causes large, disorganised eyes.

Expression of S6kScer\UAS.cMa under the control of Scer\GAL4AB1 results in a 32% increase average cell size in the salivary gland.

Ectopic expression of S6kScer\UAS.cMa under the control of Scer\GAL4ap-md544 within the developing dorsal wing compartment induces a moderate overgrowth in this unit and a bending-down of the adult wing.

Expression of S6kScer\UAS.cMa under the control of Scer\GAL4ap-md544 results in a bent down wing phenotype.

Expression of S6kScer\UAS.cMa under the control of Scer\GAL4ap-md544 causes the wing to bend down.

Expression of S6kScer\UAS.cMa under the control of Scer\GAL4ap-md544 causes a bending down of the wing. Animals expressing S6kScer\UAS.cMa under the control of Scer\GAL4GMR.PF have a normal sized eye.

Expression of S6kScer\UAS.cMa under the control of Scer\GAL4ap-md544 results in a bent-wing phenotype.

S6kScer\UAS.cMa driven by Scer\GAL4ap-md52 produces wings that are convex and bent downwards.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Suppressed by
NOT Enhancer of
Suppressor of
NOT Suppressor of
Phenotype Manifest In
Enhanced by
Suppressed by
NOT Enhancer of
Suppressor of
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

The number of autolysosomes, indicating the level of autophagy, is decreased upon co-expression of S6kScer\UAS.cMa and Tak1Scer\UAS.cTa in the developing eye disc, under the control of Scer\GAL4GMR.PF, compared to expression of Tak1Scer\UAS.cTa alone.

Depletion of Hdac3 in the eye, through expression of Hdac3dsRNA.Sym.Scer\UAS under the control of Scer\GAL4GMR.PF, strongly suppresses the overgrown, disorganised eye phenotype (with increased ommatidial size) found upon expression of S6kScer\UAS.cMa in the eye. These double-mutant flies exhibit a phenotype similar to Hdac3dsRNA.Sym.Scer\UAS single mutants.

Expression of S6kScer\UAS.cMa suppresses the rough eye phenotype seen when Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4GMR.PF.

Co-expression of S6kUAS.cMa fails to suppress the reduction in growth of the developing eye seen upon expression of PtenUAS.cHa under the control of Scer\GAL4ey.PH.

Co-expression of S6kUAS.cMa suppresses the reduction in growth of the developing eye seen upon expression of Tsc1UAS.cTa and gigUAS.cTa under the control of Scer\GAL4ey.PH.

Co-induction of Hr3dsRNA.UAS.cMa suppresses the bent-down wing phenotype seen upon induction of both S6kUAS.cMa and Hr3RB.UAS in the developing wing disc under the control of Scer\GAL4ap-md544.

Co-expression of one of bunGE12327 or bunA.Scer\UAS enhances the bent down wing phenotype caused by expression of S6kScer\UAS.cMa under the control of Scer\GAL4ap-md544.

Co-expression of bunB.Scer\UAS completely suppresses the bent down wing phenotype caused by expression of S6kScer\UAS.cMa under the control of Scer\GAL4ap-md544.

Co-expression of bunC.Scer\UAS substantially suppresses the bent down wing phenotype caused by expression of S6kScer\UAS.cMa under the control of Scer\GAL4ap-md544.

Co-expression of Akt1Scer\UAS.cRa slightly suppresses the bent wing phenotype caused by expression of S6kScer\UAS.cMa under the control of Scer\GAL4ap-md544. Co-expression of Pk61CEP837 enhances the bent wing phenotype caused by expression of S6kScer\UAS.cMa under the control of Scer\GAL4ap-md544. Co-expression of S6kScer\UAS.cMa does not result in any further increase in eye size in animals expressing Pi3K92EScer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PF. Co-expression of S6kScer\UAS.cMa does not modify the bent wing phenotype caused by expression of Pi3K92EScer\UAS.T:Hsap\MYC under the control of Scer\GAL4Bx-MS1096.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
S6kScer\UAS.cMa
S6kUAS.cMa
p70s6KScer\UAS.cMa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Montagne
Secondary FlyBase IDs
    References (17)