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General Information
Symbol
Dmel\Pdk1EP837
Species
D. melanogaster
Name
FlyBase ID
FBal0124094
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
EP837
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The P{EP} insertion is 179bp upstream of the Pk61C transcription start site.

P{EP} insertion 3875bp upstream of the putative start codon of Pk61C. P{EP} element is inserted so that expression from the Scer\UAS sequences in the element drives overexpression of Pk61C.

Insertion components
P{EP}EP837
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Neuronal expression of Pdk1EP837 under the control of Scer\GAL4elav-C155 increases sensitivity to ethanol sedation.

Age-related locomotor impairment is significantly delayed in mutant males compared to controls.

Mutant males show increased resistance to paraquat compared to controls.

Expression of Pk61CEP837 under the control of Scer\GAL4ap-md544 has no effect on the wing.

Expression of Pk61CEP837 when driven by Scer\GAL4GMR.PF causes an increase in ommatidial size (about 1.33 fold bigger than wild-type). When driven by Scer\GAL4ap-md544 the wing is convex towards the dorsal side.

Expression of Pk61CEP837 under the control of Scer\GAL4GMR.PF results in a slight but significant increase in eye size. Expression of Pk61CEP837 under the control of Scer\GAL4GMR.PB in clones of cells in the eye does not increase cell size.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
NOT Enhanced by
Suppressed by
NOT suppressed by
Enhancer of
NOT Enhancer of
NOT Suppressor of
Other
Additional Comments
Genetic Interactions
Statement
Reference

Animals expressing both Akt1Scer\UAS.cRa and Pk61CEP837 under the control of Scer\GAL4GMR.PF have a large-eye phenotype. Expression of Lk6EP30.18 in this background strongly suppresses this phenotype.

Flies co-expressing Akt1Scer\UAS.cRa and Pk61CEP837 under the control of Scer\GAL4GMR.PF have a large eye phenotype. The large eye phenotype caused by co-expression of Akt1Scer\UAS.cRa and Pk61CEP837 under the control of Scer\GAL4GMR.PF is suppressed by co-expression of scylEP22.1. The large eye phenotype caused by co-expression of Akt1Scer\UAS.cRa and Pk61CEP837 under the control of Scer\GAL4GMR.PF is suppressed by co-expression of chrbEP1035. The large eye phenotype caused by co-expression of Akt1Scer\UAS.cRa and Pk61CEP837 under the control of Scer\GAL4GMR.PF is suppressed nearly to wild type by simultaneous co-expression of both scylEP22.1 and chrbEP1035.

Co-expression of Pk61CEP837 enhances the bent wing phenotype caused by expression of S6kScer\UAS.cMa under the control of Scer\GAL4ap-md544.

When Pk61CEP837 and Akt1Scer\UAS.T:Ivir\HA1 are coexpressed under the control of Scer\GAL4GMR.PF, the eyes display a severely crumpled morphology. The eye bristles are enlarged even more severely, and the boundaries of all ommatidia and photoreceptor cells disappear. The addition of Pka-R1BDK.Scer\UAS to Pk61CEP837, Akt1Scer\UAS.T:Ivir\HA1 flies has no effect on the eye phenotype.

Coexpression of Akt1Scer\UAS.cRa and Pk61CEP837 under the control of Scer\GAL4GMR.PF causes a substantial increase in eye size. Coexpression of Akt1Scer\UAS.cRa and Pk61CEP837 under the control of Scer\GAL4GMR.PB in clones of cells in the eye results in a cell autonomous increase in cell size.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
PDK-1EP837
Pdk1EP837
Pk61CEP0837
Pk61CEP837
Name Synonyms
Secondary FlyBase IDs
    References (9)