FB2026_02 , released June 18, 2026
Allele: Dmel\scylEP22.1
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General Information
Symbol
Dmel\scylEP22.1
Species
D. melanogaster
Name
FlyBase ID
FBal0175520
Feature type
allele
Associated gene
Dmel\scyl
Associated Insertion(s)
P{EP(loxP.UAS)y+.UAS}scylEP22.1
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{EP(loxP.UAS)y+.UAS}scylEP22.1
    Cytology
    Description

    Insertion of a double headed "EP" element just upstream of scyl.

    (Reiling and Hafen, 2004)
    Allele components
    Component
    Use(s)
    Inserted element
    P{EP(loxP.UAS)y+.UAS}
    Regulatory region(s)
    UAS
    Also carries
    loxP
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Flies expressing scylEP22.1 under the control of Scer\GAL4Act5C.PI have reduced body weight compared to controls. Overall wing size is reduced by about 25% in males and 15% in females. This is due to a reduction in cell size; cell size is decreased by about 29% in males and about 21% in females compared to wild type. Clones of cells in the eye expressing scylEP22.1 under the control of Scer\GAL4GMR.PB are smaller than neighbouring wild-type cells, but no patterning defects are seen. Expression of scylEP22.1 under the control of Scer\GAL4da.G32 results in an increase in mean life span compared to control flies. Lipid levels are significantly elevated in these flies.

        (Reiling and Hafen, 2004)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        scylEP22.1 is a suppressor of increased body size phenotype of AktUAS.cRa, Pdk1EP837, Scer\GAL4GMR.PF

        (Reiling and Hafen, 2004)
        NOT Suppressor of
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        scylEP22.1 is a suppressor of eye phenotype of AktUAS.cRa, Pdk1EP837, Scer\GAL4GMR.PF

        (Reiling and Hafen, 2004)
        NOT Suppressor of
        Statement
        Reference

        chrbEP1035/scylEP22.1, Scer\GAL4GMR.PF is a non-suppressor of eye phenotype of RhebEP50.084-loxP, Scer\GAL4GMR.PF

        (Reiling and Hafen, 2004)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The large eye phenotype caused by co-expression of Akt1Scer\UAS.cRa and Pk61CEP837 under the control of Scer\GAL4GMR.PF is suppressed by co-expression of scylEP22.1. The large eye phenotype caused by co-expression of Akt1Scer\UAS.cRa and Pk61CEP837 under the control of Scer\GAL4GMR.PF is suppressed nearly to wild type by simultaneous co-expression of both scylEP22.1 and chrbEP1035. The bulging eye phenotype caused by expression of RhebEP50.084-loxP under the control of Scer\GAL4GMR.PF is not suppressed by simultaneous coexpression of both scylEP22.1 and chrbEP1035.

        (Reiling and Hafen, 2004)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        scylEP22.1
        Name Synonyms
        Secondary FlyBase IDs
          References (1)