FlyBase Gene Report: Dmel\Dcp-1

General Information

Symbol

Dmel\Dcp-1

Species

D. melanogaster

Name

Death caspase-1

Annotation Symbol

CG5370

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010501

Gene Model Status

Current

Stock Availability

17 publicly available

Enzyme Name (EC)

Gene Summary

Death caspase-1 (Dcp-1) encodes an effector caspase that cleaves specific proteins during apoptosis. It typically acts downstream of the initiator caspase encoded by Dronc. It is also involved in non-apoptotic processes such as autophagy. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Also Known As

Dcp1, caspase-1, caspase

Key Links

Genomic Location

Cytogenetic map

59E3-59E3

Sequence location

2R:23,551,313..23,553,547 [+]

Recombination map

2-103

RefSeq locus

NT_033778 REGION:23551313..23553547

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (24 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables BIR domain binding

inferred from physical interaction with FLYBASE:Diap1; FB:FBgn0260635

(Leulier et al., 2006)

enables cysteine-type endopeptidase activity

inferred from direct assay

(Wu et al., 2022, Wang et al., 1999, Song et al., 1997)

inferred from mutant phenotype

(McCall and Steller, 1998)

enables protein binding

inferred from physical interaction with FLYBASE:Diap1; FB:FBgn0260635

(Wang et al., 1999)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables cysteine-type endopeptidase activity

inferred from electronic annotation with InterPro:IPR001309, InterPro:IPR002138, InterPro:IPR002398, InterPro:IPR011600

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000047947

(GO Reference Genome Project, 2011-)

enables cysteine-type peptidase activity

inferred from electronic annotation with InterPro:IPR015917

(InterPro Project Members, 2004-)

Biological Process (15 terms)

Terms Based on Experimental Evidence (12 terms)

CV Term

Evidence

References

involved_in apoptotic process

inferred from direct assay

(Song et al., 1997)

inferred from genetic interaction with FLYBASE:egr; FB:FBgn0033483

(Li et al., 2019)

involved_in cellular response to starvation

inferred from mutant phenotype

(Hou et al., 2008)

involved_in execution phase of apoptosis

inferred from mutant phenotype

(McCall and Steller, 1998)

involved_in negative regulation of neuromuscular synaptic transmission

inferred from mutant phenotype

(Keller et al., 2011)

involved_in negative regulation of Toll signaling pathway

inferred from mutant phenotype

(Wu et al., 2022)

involved_in neuron remodeling

inferred from mutant phenotype

(Schoenmann et al., 2010)

involved_in nurse cell apoptotic process

inferred from genetic interaction with FLYBASE:Drice; FB:FBgn0019972

(Baum et al., 2007)

inferred from mutant phenotype

(McCall and Steller, 1998)

involved_in oogenesis

inferred from mutant phenotype

(DeVorkin et al., 2014, Hou et al., 2008)

involved_in positive regulation of autophagy

inferred from direct assay

(DeVorkin et al., 2014, Kim et al., 2010)

involved_in positive regulation of macroautophagy

inferred from mutant phenotype

(Hou et al., 2008)

involved_in programmed cell death involved in cell development

inferred from mutant phenotype

(Kondo et al., 2006)

involved_in programmed cell death

inferred from direct assay

(Lee et al., 2011)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in apoptotic process

inferred from biological aspect of ancestor with PANTHER:PTN000047947

(GO Reference Genome Project, 2011-)

involved_in ovarian nurse cell to oocyte transport

traceable author statement

(Kumar and Doumanis, 2000, Abrams, 1999)

involved_in positive regulation of neuron apoptotic process

inferred from biological aspect of ancestor with PANTHER:PTN000047947

(GO Reference Genome Project, 2011-)

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR001309, InterPro:IPR002138, InterPro:IPR002398, InterPro:IPR011600

(InterPro Project Members, 2004-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in mitochondrial matrix

inferred from direct assay

(DeVorkin et al., 2014)

located_in neuronal cell body

inferred from direct assay

(Hillebrand et al., 2010)

located_in neuronal ribonucleoprotein granule

inferred from direct assay

(Hillebrand et al., 2010, Barbee et al., 2006)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000047947

(GO Reference Genome Project, 2011-)

located_in cytosol

inferred from sequence or structural similarity with UniProtKB:P55210

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

CASPASES

Pathway (FlyBase)

NEGATIVE REGULATORS OF TOLL-NF-kappaB SIGNALING PATHWAY

Protein Family (UniProt)

Belongs to the peptidase C14A family. (O02002)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

cysteine-type endopeptidase activity

Summaries

Gene Snapshot

Gene Group (FlyBase)

CASPASES -: Caspases are a family of cysteine proteases that are particularly well known for their role in apoptosis. Caspases are translated as inactive zymogen precursor proteins. Initiator caspases have a large prodomain, and are cleaved to yield active enzyme in response to proapoptotic stimuli. Initiator caspases cleave and active effector (or executioner) caspases which cleave the substrates leading to programmed cell death. Caspases belong to MEROPS family C14. (Adapted from FBrf0215539).

Pathway (FlyBase)

NEGATIVE REGULATORS OF TOLL-NF-kappaB SIGNALING PATHWAY -: In Drosophila, the canonical Toll signaling pathway is initiated by the binding of a spatzle ligand to Toll (Tl) or a Toll-like receptor leading to the nuclear localization of the NF-κB (dl or Dif) transcription factor. Negative regulators of Toll-NF-κB Signaling lead to the increased cytosolic retention of the NF-κB proteins dl or Dif and/or repression of target gene transcription. (Adapted from FBrf0091014 and FBrf0223077).

Protein Function (UniProtKB)

Involved in the activation cascade of caspases responsible for apoptosis execution (By similarity). Proteolytically cleaves Poly

(UniProt, O02002)

Summary (Interactive Fly)

ICE/CED-3 protease involved in apoptosis - an effector caspase - cleaves specific proteins during apoptosis - acts downstream of the initiator caspase Dronc - involved in non-apoptotic processes such as autophagy

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Dcp-1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry O02002)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Dcp-1-RA

FBtr0072062

NM_057626

1749

323

Additional Transcript Data and Comments

Reported size (kB)

1.8 (longest cDNA)

(Song et al., 1997)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Dcp-1-PA

FBpp0071971

35.9

323

7.83

O02002

NP_476974

AAF47027

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

323 (aa); 22 <&> 13 (kD observed)

(Song et al., 1997)

Comments

External Data

Subunit Structure (UniProtKB)

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 22 kDa (p22) and a 13 kDa (p13) subunit.

(UniProt, O02002)

Crossreferences

InterPro - A database of protein families, domains and functional sites

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

C14.016

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dcp-1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dcp-1_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.62

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Song et al., 1997)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 1 -- 5

organism | ubiquitous | uniform

(Song et al., 1997)

embryonic stage 4 -- 6

organism | intense | ubiquitous

(Fisher et al., 2012)

embryonic stage 5 -- 10

organism | ubiquitous

Comment: expressed in all cells

(Song et al., 1997)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic foregut

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic optic lobe primordium

(Fisher et al., 2012)

embryonic stage 16 -- 17

embryonic/larval hindgut

(Song et al., 1997)

gonad

(Song et al., 1997)

embryonic head

(Song et al., 1997)

larval central nervous system | restricted

Comment: cells along midline

(Song et al., 1997)

Additional Descriptive Data

The Dcp-1 transcript is uniformly distributed in early and mid stage embryos. Dcp-1 expression becomes more restricted in late embryogenesis, with strong staining in parts of the central nervous system, the gut, gonads and the head.

(Song et al., 1997)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in mitochondrial matrix

inferred from direct assay

(DeVorkin et al., 2014)

located_in neuronal cell body

inferred from direct assay

(Hillebrand et al., 2010)

located_in neuronal ribonucleoprotein granule

inferred from direct assay

(Hillebrand et al., 2010, Barbee et al., 2006)

Expression Deduced from Reporters

Reporter: P{PZ}Dcp-1⁰²¹³²

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

imaginal disc

(Meister and Braun, 1995.10)

larval brain

(Meister and Braun, 1995.10)

embryonic/larval fat body

(Meister and Braun, 1995.10)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Dcp-1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dcp-1

View exonic expression by tissue for Dmel\Dcp-1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010501

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37729/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010501

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010501

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010501

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5370

Flygut - An atlas of the Drosophila adult midgut

FBgn0010501

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Dcp-1

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 20 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 27 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dcp-1

Transgenic constructs containing regulatory region of Dcp-1

Aberrations (Deficiencies and Duplications) ( 13 )

Inferred from experimentation ( 13 )

Gene disrupted in

Df(2R)bw5

(Song et al., 1997)

Df(2R)bw^VDe2LPx^KR

(Spradling et al., 1999, Beaton, 1997.12.27, BDGP Project Members, 1994-1999)

Df(2R)bw-DRa

(Song et al., 1997)

Df(2R)bw-S46

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)Exel7180

(Ryder, 2004.4.26)

Gene not disrupted in

In(2LR)lt^G10LBR27^R

(Song et al., 1997)

Gene partially disrupted in

Df(2R)ahd2

(Sage et al., 2005)

Df(2R)ahf6

(Sage et al., 2005)

Df(2R)csa3

(Sage et al., 2005)

Df(2R)csa7

(Sage et al., 2005)

Df(2R)levy²

(Liu et al., 2007)

Df(2R)levy³

(Liu et al., 2007)

Df(2R)levy⁴

(Liu et al., 2007)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of pupal stage

Dcp-1^ΔN.GMR

partially lethal, with Scer\GAL4^GMR.PF

Dcp-1^UAS.cKa

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Dcp-1^GD10729

viable, with Scer\GAL4^GMR.PF

Dcp-1^UAS.cKa

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Dcp-1^GD10729

Sterility

Allele

sterile, with Scer\GAL4^{VP16.nanos.UTR}

Dcp-1^ΔN.UASp

Other Phenotypes

Allele

abnormal cell death

Dcp-1^Prev1

abnormal cell death, with Scer\GAL4^Crz.504

Dcp-1^RNAi.UAS

abnormal cell death | adult stage | nutrition conditional

abnormal cell death | P-stage | recessive

Dcp-1^Prev1

abnormal eye color

Dcp-1^ΔN.GMR

abnormal eye color, with Scer\GAL4^GMR.PFa

Dcp-1^UAS.cKa

abnormal neuroanatomy, with Scer\GAL4^elav-C155

Dcp-1^UAS.cKa

abnormal neurophysiology, with Scer\GAL4^elav-C155

Dcp-1^UAS.cKa

abnormal size | adult stage, with Scer\GAL4^C10

Dcp-1^KK106134

abnormal starvation stress response

Dcp-1⁰²¹³²

abnormal starvation stress response, with Scer\GAL4^da.G32

Dcp-1^GD10729

decreased cell death

Dcp-1^Prev1

decreased cell death | adult stage | nutrition conditional

Dcp-1^Prev1

increased cell death

Dcp-1^Prev1

increased cell death, with Scer\GAL4^GMR.PF

Dcp-1^UAS.cKa

increased cell death, with Scer\GAL4^ninaE.PT

Dcp-1^UAS.cPa

increased cell death | adult stage, with Scer\GAL4^{VP16.nanos.UTR}

Dcp-1^ΔN.UASp

increased cell death | adult stage, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^nanos.PG

Dcp-1^UASp.cHa

increased cell death | larval stage, with Scer\GAL4^C10

Dcp-1^KK106134

short lived, with Scer\GAL4^GMR.PF

Dcp-1^UAS.cKa

some die during pupal stage

Dcp-1^ΔN.GMR

visible

visible, with Scer\GAL4^GMR.PF

Dcp-1^UAS.cKa

visible | adult stage, with Scer\GAL4^ap-md544

visible | adult stage, with Scer\GAL4^C10

Dcp-1^KK106134

visible | adult stage, with Scer\GAL4^GMR.PFa

Dcp-1^UAS.cKa

Phenotype manifest in

Allele

actin filament & nurse cell, with Scer\GAL4^{VP16.nanos.UTR}

Dcp-1^ΔN.UASp

adult optic lobe | P-stage

Dcp-1^Prev1

autophagosome

Dcp-1⁰²¹³²

autophagosome, with Scer\GAL4^da.G32

Dcp-1^GD10729

chaeta | increased number

Dcp-1^Prev1

dendrite

Dcp-1^Prev1

egg chamber

Dcp-1^UASp.cHa

egg chamber, with Scer\GAL4^{VP16.nanos.UTR}

Dcp-1^ΔN.UASp

egg chamber, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^nanos.PG

Dcp-1^UASp.cHa

egg chamber | conditional

Dcp-1^Prev1

egg chamber | nutrition conditional

eye

eye, with Scer\GAL4^GMR.PF

Dcp-1^UAS.cKa

eye, with Scer\GAL4^GMR.PFa

Dcp-1^UAS.cKa

eye disc

Dcp-1^Prev1

female germline cyst | nutrition conditional

Dcp-1^Prev1

follicle cell

Dcp-1^UASp.cHa

follicle cell | nutrition conditional

germarium region 2 | nutrition conditional

Dcp-1^Prev1

male germline cell

Dcp-1^Prev1

mitochondrion | nutrition conditional

Dcp-1^Prev1

neuron

Dcp-1^Prev1

neuron, with Scer\GAL4^Crz.504

Dcp-1^RNAi.UAS

outer photoreceptor cell, with Scer\GAL4^ninaE.PT

Dcp-1^UAS.cPa

pigment cell

spermatogonial cyst

Dcp-1^Prev1

wing, with Scer\GAL4^ap-md544

wing, with Scer\GAL4^C10

Dcp-1^KK106134

wing disc, with Scer\GAL4^C10

Dcp-1^KK106134

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (16)

Hsap\CASP7

12 of 14

Yes

Hsap\CASP3

11 of 14

Yes

Hsap\CASP6

4 of 14

Hsap\CASP1

3 of 14

Yes

Hsap\CASP2

3 of 14

Hsap\CASP4

3 of 14

Yes

Hsap\CASP5

3 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\CASP14

2 of 14

Hsap\CFLAR

2 of 14

Hsap\CARD16

1 of 14

Yes

Hsap\CARD18

1 of 14

Hsap\PEA15

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (12)

Rnor\Casp3

11 of 14

Yes

Rnor\Casp7

11 of 14

Yes

Rnor\Casp1

3 of 14

Yes

Rnor\Casp2

3 of 14

Rnor\Casp4

3 of 14

Yes

Rnor\Casp6

3 of 14

Rnor\Casp12

3 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (13)

Mmus\Casp7

12 of 14

Yes

Mmus\Casp3

11 of 14

Yes

Mmus\Casp6

4 of 14

Mmus\Casp1

3 of 14

Yes

Mmus\Casp2

3 of 14

Mmus\Casp4

3 of 14

Yes

Mmus\Casp9

3 of 14

Mmus\Casp12

3 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (11)

Xtro\casp7

9 of 13

Yes

Xtro\casp3.2

6 of 13

Yes

Xtro\casp3.1

4 of 13

Yes

Xtro\casp6

4 of 13

Yes

Xtro\casp2

2 of 13

Xtro\casp1

1 of 13

Yes

Xtro\casp8

1 of 13

Yes

Xtro\LOC100486257

1 of 13

Yes

Xtro\oit3

1 of 13

Yes

Xtro\sh3rf2

1 of 13

Xtro\XB5812047

1 of 13

Danio rerio (Zebrafish) (23)

Drer\casp7

12 of 14

Yes

Drer\casp3a

11 of 14

Yes

Drer\casp3b

11 of 14

Yes

Drer\casp21

6 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Drer\casp22

3 of 14

Drer\casp23

3 of 14

Yes

Drer\caspa

3 of 14

Yes

Drer\caspb

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\cflara

2 of 14

Drer\LOC798445

1 of 14

Yes

Drer\LOC100332177

1 of 14

Yes

Drer\pea15

1 of 14

Yes

Drer\si:ch211-195h23.3

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\ced-3

9 of 14

Yes

Cele\csp-2

6 of 14

Cele\csp-1

5 of 14

Cele\csp-3

4 of 14

Yes

Cele\ZK795.2

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (17)

Agam\CASPS7

9 of 12

Yes

Agam\CASPS8

7 of 12

Yes

Agam\CASPS1

6 of 12

Yes

Agam\CASPS2

6 of 12

Yes

6 of 12

6 of 12

6 of 12

6 of 12

6 of 12

5 of 12

5 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Dcp-1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

12 of 13

9 of 13

4 of 13

4 of 13

3 of 13

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Dcp-1^RNAi.UAS.cUa

ameliorates high grade glioma

modeled by Ras85D^V12.cUa.UAS

(Liu et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

12 of 14

11 of 14

4 of 14

3 of 14

CASPASE 1, APOPTOSIS-RELATED CYSTEINE PROTEASE; CASP1

CASP2; caspase 2

3 of 14

600639

INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 80, WITH VARIANT LISSENCEPHALY; MRT80

3 of 14

3 of 14

3 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Dcp-1 - Diap1

anti tag coimmunoprecipitation, western blot, pull down, anti tag western blot

(Leulier et al., 2006, Tenev et al., 2005)

Dcp-1 - Dif

anti tag coimmunoprecipitation, anti tag western blot

(Wu et al., 2022)

Dcp-1 - Drice

enzymatic study, autoradiography, western blot

(Choutka et al., 2017, DeVorkin et al., 2014)

Dcp-1 - Hsp83

anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry

(Choutka et al., 2017)

Dcp-1 - sesB

anti tag coimmunoprecipitation, western blot, peptide massfingerprinting

(DeVorkin et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Dcp-1

suppressible

Acn

(Nandi et al., 2014)

enhanceable

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

suppressible

(Shinoda et al., 2019)

Dcp-1

suppressible

Atg18a

(Shinoda et al., 2019, Kim et al., 2010)

enhanceable

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

Dcp-1

suppressible

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

suppressible

(Sinenko, 2017, Zhou et al., 1999)

enhanceable

(Kim et al., 2010)

suppressible

(Kim et al., 2010, Peterson et al., 2003)

enhanceable

(Lee et al., 2011)

suppressible

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

enhanceable

(Song et al., 2000)

Dcp-1

enhanceable

hid

(Song et al., 2000)

Dcp-1

suppressible

lncRNA:Hsrω

(Mallik and Lakhotia, 2009)

suppressible

(Kim et al., 2010)

suppressible

(Mendes et al., 2009)

enhanceable

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

enhanceable

(Song et al., 2000, Zhou et al., 1999)

suppressible

(Kim et al., 2010)

suppressible

(DeVorkin et al., 2014)

suppressible

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

suppressible

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

enhanceable

(Kim et al., 2010)

suppressible

(Sinenko, 2017)

suppressible

(Kim et al., 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Acn

enhanceable

Dcp-1

(Nandi et al., 2014)

Ank2

suppressible

Dcp-1

(Keller et al., 2011)

Drice

enhanceable

Dcp-1

(Muro et al., 2006, Xu et al., 2006)

Drice|hid

suppressible

Dcp-1

(Leulier et al., 2006)

Drice|Diap1

suppressible

Dcp-1|Damm|Decay

(Leulier et al., 2006)

enhanceable

(Lee et al., 2011)

suppressible

(Shima et al., 2025)

hid

suppressible

Drice|Dcp-1

(Leulier et al., 2006)

nanos

suppressible

Dcp-1

(Bhogal et al., 2016)

rpr

suppressible

Dcp-1

(Ikegawa et al., 2023)

rpr

enhanceable

Dcp-1

(Zhou et al., 1999)

suppressible

(Fan et al., 2014)

suppressible

(Sulekh et al., 2024, Ikegawa et al., 2023)

External Data

Subunit Structure (UniProtKB)

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 22 kDa (p22) and a 13 kDa (p13) subunit.

(UniProt, O02002 )

Linkouts

BioGRID - A database of protein and genetic interactions.

63329

DroID - A comprehensive database of gene and protein interactions.

FBgn0010501

MIST (genetic) - An integrated Molecular Interaction Database

37729

MIST (protein-protein) - An integrated Molecular Interaction Database

37729

Pathways

Signaling Pathways (FlyBase)

NEGATIVE REGULATORS OF TOLL-NF-kappaB SIGNALING PATHWAY

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-103

Cytogenetic map

59E3-59E3

Sequence location

2R:23,551,313..23,553,547 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

59E3-59E3

Limits computationally determined from genome sequence between P{lacW}l(2)s4830^s4830&P{lacW}chrw^k06908 and P{PZ}Dcp-1⁰²¹³²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

59F-59F

(Song, 1997.4.28)

59E3-59E4

(determined by in situ hybridisation)

(Spradling et al., 1999, Beaton, 1998.1.8)

59F2-59F3

(determined by in situ hybridisation)

(Beaton, 1997.12.27)

59F-59F

(determined by in situ hybridisation)

(Song et al., 1997)

59E3-59E4

59F2--3

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-103

(FlyBase, 2016)

2-108.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (17)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

63815

y¹ w^*; Dcp-1³

63814

y¹ w^*; Dcp-1^Prev1

28909

y¹ v¹; P{TRiP.HM05120}attP2

66636

w^*; P{ST.lexA::HG}Dcp-1^VF-1

80877

y¹, v¹; P{TKO.GS04781}attP40/CyO

Kyoto

108865

cn¹ P{PZ}Dcp-1⁰²¹³²/CyO; ry⁵⁰⁶

108854

y¹ w^67c23; P{lacW}Dcp-1^k05606/CyO

5370R-2

v107560

v34328

w¹¹¹⁸; P{GD10729}v34328

v34330

w¹¹¹⁸; P{GD10729}v34330

v342888

P{hsFLP}1, y1 w1118; P{HD_CFD02451}attP40/CyO-GFP

More stocks available...

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (49)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD13945

Other clones

DPiM_LD13945

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010501

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010501

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Hasan et al., 2015)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Dcp-1 is a positive regulator of starvation-induced autophagic flux during oogenesis.

(DeVorkin et al., 2014)

Loss of Dcp-1 promotes mitochondrial elongation.

(DeVorkin et al., 2014)

Dcp-1 controls autophagic flux by a mechanism involving the regulation of the mitochondrial network and maintenance of ATP levels.

(DeVorkin et al., 2014)

Pro-Dcp-1 interacts with sesB in a non-proteolytic manner to regulate its stability.

(DeVorkin et al., 2014)

Ice is activated in wing discs after irradiation.

(Florentin and Arama, 2012)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

The lethality, imaginal disc and melanotic tumor phenotypes of P insertions in the overlapping Dcp-1/pita locus are caused by disruption of pita and not Dcp-1.

(Laundrie et al., 2003)

th promotes cell survival by blocking the activity of the Dcp-1 gene product.

(Wang et al., 1999)

Dcp-1 cleaves caspase substrates and induces apoptosis in cultured cells.

(McCall et al., 1997)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Dcp-1 CG5370

(Zhang, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

CG5370

(National Institute of Genetics Fly Stocks, 2022-, Neuert et al., 2017, Hosono et al., 2015, Chakrabarti et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Li et al., 2009, Perkins et al., 2009)

DCP-1

(Coutinho-Budd et al., 2024, Heron et al., 2023, Periasamy et al., 2022, Brown Rackley et al., 2020, Khan et al., 2017, Eroglu and Derry, 2016, Harris et al., 2016, Zhang et al., 2015, Creagh et al., 2009, Khan et al., 2008, Shin and Yoo, 2008, Kim and Yoo, 2007, Shin and Yoo, 2007, Tenev et al., 2007, Tenev et al., 2005, Olson et al., 2003, Igaki et al., 2002, Jabbour et al., 2002, Srinivasula et al., 2002, Harvey et al., 2001, Huh et al., 2001, Matova and Cooley, 2001, Yu et al., 2001, Baehrecke, 2000, Gaumer et al., 2000, Hawkins et al., 2000, Meier et al., 2000, Song et al., 2000, Dorstyn et al., 1999, Hawkins et al., 1999, Miller, 1999, Bergmann et al., 1998, Cory and Adams, 1998, Green and Kroemer, 1998, McCall and Steller, 1998, Meier and Evan, 1998, Fraser et al., 1997, Jallepalli and Bogyo, 1997, Song, 1997.4.28)

DCP1

(Hirooka et al., 2025, Liu et al., 2021, Toshniwal et al., 2019, Wang et al., 2017, Shin et al., 2013, Kessler and Müller, 2009, Jones et al., 2000)

DCp-1

(Stephano et al., 2018)

Dcp-1

(Braun et al., 2025, He et al., 2025, Hingole et al., 2025, Hounsell and Fan, 2025, Klemm et al., 2025, Kong et al., 2025, Mira-Osuna et al., 2025, Molano-Fernández et al., 2025, Mukherjee et al., 2025, Muramoto et al., 2025, Scopelliti et al., 2025, Sproston et al., 2025, Xiao et al., 2025, Yadav et al., 2025, Ahmed-de-Prado et al., 2024, Bhattacharya et al., 2024, Cruz et al., 2024, Jang et al., 2024, Jeong, 2024, Kodra et al., 2024, Nair and Baker, 2024, Sadanandappa and Bosco, 2024, Soares et al., 2024, Umargamwala et al., 2024, Chafino et al., 2023, Huang et al., 2023, Kietz and Meinander, 2023, Markus et al., 2023, Muita and Baxter, 2023, Shinoda et al., 2023, Zheng et al., 2023, Aggarwal et al., 2022, Dziedziech and Theopold, 2022, Feng et al., 2022, Tarikere et al., 2022, Valencia-Expósito et al., 2022, Buhlman et al., 2021, Hounsell and Fan, 2021, Lebo and McCall, 2021, Sadanandappa et al., 2021, Sharma et al., 2021, Yang and Choi, 2021, Ford et al., 2020, Krautz et al., 2020, Mehrotra et al., 2020, Pop et al., 2020, Sankaranarayanan and Weil, 2020, Xu et al., 2020, Zeng et al., 2020, Bozler et al., 2019, Doktór et al., 2019, Guo et al., 2019, Katsube et al., 2019, Li et al., 2019, Park et al., 2019, Russo et al., 2019, Tettamanti and Casartelli, 2019, Wang et al., 2019, Wu et al., 2019, Ahmed-de-Prado et al., 2018, Chi et al., 2018, Diwanji and Bergmann, 2018, Gene Disruption Project members, 2018-, Mondal et al., 2018, Choutka et al., 2017, Nakajima and Kuranaga, 2017, Transgenic RNAi Project members, 2017-, Bhogal et al., 2016, Chen et al., 2016, Dabrowska et al., 2016, Eroglu and Derry, 2016, Kawamoto et al., 2016, Klebanow et al., 2016, Kockel et al., 2016, Melzer and Broemer, 2016, Urbach et al., 2016, Arya and White, 2015, Babcock and Ganetzky, 2015, Nicolson et al., 2015, Sakamaki et al., 2015, Sudmeier et al., 2015, Zhang et al., 2015, Bischof and FlyORF project members, 2014.6.20, DeVorkin et al., 2014, McCall, 2014.7.9, Nandi et al., 2014, Steller et al., 2014.7.9, Tamori and Deng, 2014, Yang et al., 2013, Chakrabarti et al., 2012, Chen et al., 2012, Florentin and Arama, 2012, Japanese National Institute of Genetics, 2012.5.21, Pushpavalli et al., 2012, Keller et al., 2011, Lee et al., 2011, Kim et al., 2010, Li et al., 2010, Schoenmann et al., 2010, Li et al., 2009, Hou et al., 2008, Somma et al., 2008, Buszczak et al., 2007, Copeland et al., 2007, Fan and Bergmann, 2007, Kuranaga and Miura, 2007, Langille and Clark, 2007, Liu et al., 2007, Peng et al., 2007, Baehrecke, 2006, Dworkin and Gibson., 2006, Minakhina and Steward, 2006, Moskalev et al., 2006, Muro et al., 2006, Jordan et al., 2005, Kornbluth and White, 2005, Moskalev and Zainullin, 2004, Wang et al., 1999)

cDcp

(Ishibashi et al., 2021)

cDcp-1

(Wu et al., 2021)

ccp1

(Amarneh et al., 2009)

dcp-1

(Mendoza Andrade et al., 2025, Xie et al., 2021, Orr et al., 2020, Sun et al., 2020, Hao et al., 2019, Robin et al., 2019, Napoletano et al., 2017, Akagawa et al., 2015, Zhang et al., 2015, Lee et al., 2013, Lee et al., 2013, Yacobi-Sharon et al., 2013, Etchegaray et al., 2012, Miura, 2012, Pritchett and McCall, 2012, Fan and Bergmann, 2010, Schoenmann et al., 2010, Denton et al., 2009, Mallik and Lakhotia, 2009, Mendes et al., 2009, Xu et al., 2009, Denton et al., 2008, Fan and Bergmann, 2008, Baum et al., 2007, McCall et al., 2007, Primrose et al., 2007, Kondo et al., 2006, Leulier et al., 2006, Mendes et al., 2006, Xu et al., 2006, Xu et al., 2006, Baum et al., 2005, Kilpatrick et al., 2005, Kondo et al., 2005, Moon et al., 2005, Zheng et al., 2005, Cakouros et al., 2004, McCall, 2004, Peterson et al., 2004, Barkett et al., 2003, Bergmann et al., 2003, McCall et al., 2003, Peterson et al., 2003, Laundrie and McCall, 2002, Peterson et al., 2002, Richardson and Kumar, 2002, Buszczak et al., 2001, McCall et al., 2001, Buszczak and Cooley, 2000, Kumar and Doumanis, 2000, Vernooy et al., 2000, Bergmann et al., 1999, Varkey et al., 1999, Zhou et al., 1999, Hoffmann and Reichhart, 1997, McCall and Steller, 1997)

dcp1

(Brutscher et al., 2025, Shima et al., 2025, Luo et al., 2024, Barrio et al., 2023, Amcheslavsky et al., 2018, Smart et al., 2017, Liang et al., 2014, Lee et al., 2013, Khammari et al., 2011, Foglietti et al., 2006, Moskalev, 2001)

l(2)01862

l(2)02132

Name Synonyms

Death caspase-1

(Crossman et al., 2018, Klebanow et al., 2016, Steller et al., 2014.7.9, Etchegaray et al., 2012, Tsuda et al., 2006)

Death-caspase-1

(Yamada et al., 2023)

caspase

(Bose et al., 1998, Kondo et al., 1997)

caspase 1

(Khan et al., 2008)

caspase-1

(White et al., 1999, Song, 1997.4.28)

death caspase 1

(Urbach et al., 2016)

death caspase-1

(Mendes et al., 2009, Hou et al., 2008)

Secondary FlyBase IDs

FBgn0010509

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 59 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37729

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

O02002

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

O02002

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

O02002

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010501

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37729/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010501

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010501

FlyMine - An integrated database for Drosophila genomics

FBgn0010501

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG5370

MARRVEL_MODEL - MARRVEL (model organism gene)

37729

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

C14.016

Linkouts

BioGRID - A database of protein and genetic interactions.

63329

Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.

9578

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010501

DroID - A comprehensive database of gene and protein interactions.

FBgn0010501

DRSC - Results frm RNAi screens

FBgn0010501

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dcp-1_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010501

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010501

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5370

Flygut - An atlas of the Drosophila adult midgut

FBgn0010501

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010501

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC003841

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

37729

MIST (protein-protein) - An integrated Molecular Interaction Database

37729

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (379)

The following external sites may use different assemblies or annotations than FlyBase.

-0.62

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